Pan-cancer characterization of ncRNA synergistic competition uncovers potential carcinogenic biomarkers DOI Creative Commons
Junpeng Zhang, Lin Liu, Xuemei Wei

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 1, 2023

Abstract Non-coding RNAs (ncRNAs) act as important modulators of gene expression and they have been confirmed to play critical roles in the physiology development malignant tumors. Understanding synergism multiple ncRNAs competing endogenous RNA (ceRNA) regulation can provide insights into mechanisms tumors caused by ncRNA regulation. In this work, we present a framework, SCOM, for identifying synergistic competition. We systematically construct landscape competition across 31 tumors, reveal that tend share hub rather than interactions involved addition, (i.e. competition) are likely be drug resistance, contribute distinguishing molecular subtypes participate immune Furthermore, SCOM help infer uncover potential diagnostic prognostic biomarkers Altogether, framework resulting web-based database SCOMdb ( www.comblab.cn/SCOMdb/ ) serve useful resource exploring accelerate identification carcinogenic biomarkers. Author summary Abundant evidence reveals expression, it is us understand hypothesize acting ceRNAs crosstalk with each other form name hypothesis . To biomarkers, From perspective competition, shown involve believe proposed design reliable diagnosis treatment

Language: Английский

From periphery to center stage: 50 years of advancements in innate immunity DOI Creative Commons
Susan Carpenter, Luke O'neill

Cell, Journal Year: 2024, Volume and Issue: 187(9), P. 2030 - 2051

Published: April 1, 2024

Over the past 50 years in field of immunology, something a Copernican revolution has happened. For long time, immunologists were mainly concerned with what is termed adaptive immunity, which involves exquisitely specific activities lymphocytes. But other arm so-called "innate immunity," had been neglected. To celebrate Cell's 50th anniversary, we have put together review processes and components innate immunity trace seminal contributions leading to modern state this field. Innate joined center interest for all those who study body's defenses, as well homeostasis pathology. We are now entering era where therapeutic targeting immune receptors downstream signals hold substantial promise infectious inflammatory diseases cancer.

Language: Английский

Citations

37
Small and long non-coding RNAs: Past, present, and future DOI
Ling‐Ling Chen, V. Narry Kim

Cell, Journal Year: 2024, Volume and Issue: 187(23), P. 6451 - 6485

Published: Nov. 1, 2024

Language: Английский

Citations

33
Current understanding of functional peptides encoded by lncRNA in cancer DOI Creative Commons
Hua Tian, Lu Tang, Zihan Yang

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 19, 2024

Abstract Dysregulated gene expression and imbalance of transcriptional regulation are typical features cancer. RNA always plays a key role in these processes. Human transcripts contain many RNAs without long open reading frames (ORF, > 100 aa) that more than 200 bp length. They usually regarded as non-coding (lncRNA) which play an important cancer regulation, including chromatin remodeling, translational miRNA sponges. With the advancement ribosome profiling sequencing technologies, increasing research evidence revealed some ORFs lncRNA can also encode peptides participate multiple organ tumors, undoubtedly opens new chapter field oncology research. In this review, we discuss biological function current methods to evaluate their coding potential functional small encoded by cancers. Investigating understanding regulatory mechanisms may contribute deeper development targeted anticancer therapies.

Language: Английский

Citations

9
Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology DOI Creative Commons

S.-H.I. Ou,

Xiaoya Nie,

Xiangyu Qiu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 18, 2025

A new type of nonapoptotic, iron-dependent cell death induced by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including inflammation and cancer, have been demonstrated to be influenced changes in the ferroptosis-regulating network. Long non-coding RNAs (LncRNAs) are a group functional RNA molecules that not translated into proteins, which can regulate gene expression various manners. An increasing number studies shown lncRNAs interfere with progression ferroptosis modulating ferroptosis-related genes directly or indirectly. Despite evidence implicating cancer inflammation, on their mechanisms therapeutic potential remain scarce. We investigate lncRNA-mediated regulation immunity, assessing feasibility challenges targets these conditions.

Language: Английский

Citations

1
Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential DOI Open Access
Wen-Qin Zhang, Yuanliang Yan, Jinwu Peng

et al.

Cancers, Journal Year: 2022, Volume and Issue: 15(1), P. 286 - 286

Published: Dec. 31, 2022

Exosomes are nanovesicles secreted into biofluids by various cell types and have been implicated in different physiological pathological processes. Interestingly, a plethora of studies emphasized the mediating role exosomes bidirectional communication between donor recipient cells. Among cargoes exosomes, long non-coding RNAs (lncRNAs) identified as crucial regulators cancer cells immune tumor microenvironment (TME) that can interfere with innate adaptive responses to affect therapeutic efficiency. Recently, few major focused on exosomal lncRNA-mediated interaction infiltrated TME. Nevertheless, dearth pertains regulating lncRNAs is still early stages. Comprehensive mechanisms immunity not well understood. Herein, we provide an overview immunomodulatory function treatment resistance. In addition, also summarize potential strategies toward

Language: Английский

Citations

31
Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential DOI Creative Commons
Nikolay K. Shakhpazyan, Л.М. Михалева, A.L. Bedzhanyan

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2411 - 2411

Published: Aug. 28, 2023

This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within colorectal cancer (CRC) microenvironment, intersecting domains immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in pathogenesis CRC, immune evasion, treatment response to have crucial implications inflammation serve as promising candidates for novel strategies biomarkers. scrutinizes interaction lncRNAs with Consensus Molecular Subtypes (CMSs) their complex interplay tumor stroma affecting immunity inflammation, conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into relationship between other RNAs, including microRNAs circular mediating cell-to-cell communication CRC microenvironment. Lastly, propose potential manipulate enhance anti-tumor thereby underlining significance devising innovative interventions CRC.

Language: Английский

Citations

19
Lnc-ing RNA to intestinal homeostasis and inflammation DOI
Katherine A. Fitzgerald, Liraz Shmuel-Galia

Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(2), P. 127 - 137

Published: Jan. 18, 2024

Language: Английский

Citations

7
Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm DOI Creative Commons
Jing Zhang,

Le Wu,

Chenchen Wang

et al.

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 1385 - 1398

Published: April 1, 2024

In the past few decades, chemotherapy has been one of most effective cancer treatment options. Drug resistance is currently greatest obstacles to treatment. Even though drug mechanisms have extensively investigated, they not fully elucidated. Recent genome-wide investigations revealed existence a substantial quantity long non-coding RNAs (lncRNAs) transcribed from human genome, which actively participate in numerous biological processes, such as transcription, splicing, epigenetics, cell cycle, differentiation, development, pluripotency, immune microenvironment. The abnormal expression lncRNA considered contributing factor resistance. Furthermore, may be influenced by genetic and epigenetic variations, well individual differences patient response, attributable polymorphisms metabolic enzyme genes. This review focuses on mechanism lncRNAs target drugs study tumors with high mortality, aiming establish theoretical foundation for targeted therapy.

Language: Английский

Citations

7
Long Noncoding RNA Mir17hg and D43Rik Control the Macrophage Response to Toxoplasma gondii Infection DOI Open Access
Claire M. Doherty, Jessica Belmares-Ortega, Breanne E. Haskins

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Long noncoding (lnc) RNAs are emerging as imported regulators of immunity but how they impact the host response to infection is still largely unknown. In previous screening studies we identified Mir17hg and D43Rik lncRNAs upregulated in mouse bone marrow-derived macrophages regardless parasite strain type. Here, examined during macrophages. Expression these was transiently increased by T. gondii , peaking 6 hr post falling background noninfected levels 18 hrs. Both were predominantly localized cell nucleus, suggesting roles gene regulation. Using a lncRNA silencing approach mediated siRNA, uncovered evidence that both involved modulating transcriptional with Type I II strains Toxoplasma . These effects most dramatic high virulence RH, where resulted expression broad panel immunity-related genes. Our results implicate important molecular macrophage

Language: Английский

Citations

0
Circulating lncRNAs as biomarkers for severe dengue using a machine learning approach DOI Creative Commons

Rodolfo Katz,

Nguyen Minh Nam,

Túlio de Lima Campos

et al.

Journal of Infection, Journal Year: 2025, Volume and Issue: unknown, P. 106471 - 106471

Published: March 1, 2025

Dengue virus (DENV) infection is a significant global health concern, causing severe morbidity and mortality. While many cases present as mild febrile illness, some progress to life-threatening dengue (SD). Early intervention essential improve outcomes, but current predictive methods lack specificity, burdening healthcare systems in endemic regions. Circulating long non-coding RNAs (lncRNAs) have emerged stable promising biomarkers. This study explored the use of lncRNAs markers for SD. Differential expression qPCR arrays were employed identify associated with Candidate validated, their plasma levels measured cohort Vietnamese patients (n =377) healthy controls (n=128) at admission. Machine learning algorithms applied predict probability SD progression. The model demonstrated high sensitivity an area under curve (AUC) 0.98 (95% CI: 0.96-1.0). At admission, it accurately identified 17 18 who later died high-risk, compared traditional warning signs, which flagged only 9 these cases. Our findings suggest that this panel has potential SD, could help reduce burden patient management countries.

Language: Английский

Citations

0