The biology and function of extracellular vesicles in immune response and immunity

Immunity, Journal Year: 2024, Volume and Issue: 57(8), P. 1752 - 1768

Published: Aug. 1, 2024

Language: Английский

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Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases

Cosmetics, Journal Year: 2023, Volume and Issue: 10(2), P. 65 - 65

Published: April 20, 2023

Exosomes are small extracellular nanovesicles that released by cells, and their potential has been explored for use in cosmetics, skin care, tissue regeneration, dermatological diseases. The therapeutic value of exosomes lies ability to modulate the microenvironment regulate gene expression, induce cell differentiation, which can have a positive impact on health. In terms used reduce wrinkles, improve texture hydration, enhance elasticity, as well inflammation damage caused UV radiation. Furthermore, promote regeneration wounds treat diseases such systemic lupus erythematosus, psoriasis, atopic dermatitis, sclerosis, pigment regulation, vitiligo, hair growth. this review, field diseases, elaborated. existing literature demonstrated with further research, may become viable option many conditions.

Language: Английский

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Extracellular Vesicles in Colorectal Cancer: From Tumor Growth and Metastasis to Biomarkers and Nanomedications

Cancers, Journal Year: 2023, Volume and Issue: 15(4), P. 1107 - 1107

Published: Feb. 9, 2023

Colorectal cancer (CRC) is a leading public health concern due to its incidence and high mortality rates, highlighting the requirement of an early diagnosis. Evaluation circulating extracellular vesicles (EVs) might constitute noninvasive reliable approach for CRC detection patient follow-up because EVs display molecular features cells they originate. are released by almost all cell types mainly categorized as exosomes originating from exocytosis intraluminal multivesicular bodies, ectosomes resulting outward budding plasma membrane apoptotic bodies’ ensuing shrinkage. These play critical role in intercellular communications during physiological pathological processes. They facilitate progression premetastatic niche formation, enable transfer chemotherapy resistance sensitive through local or remote delivery their lipid, nucleic acid protein content. On another note, stability bloodstream, permeation tissues sheltering packaged material make engineered suitable vectors efficient tracers therapeutic agents tumor imaging treatment. Here, we focus on physiopathological CRCs, value diagnosis prognosis ongoing investigations into approaches.

Language: Английский

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Exosomal long non-coding RNAs in cancer: Interplay, modulation, and therapeutic avenues

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(3), P. 887 - 900

Published: April 4, 2024

In the intricate field of cancer biology, researchers are increasingly intrigued by emerging role exosomal long non-coding RNAs (lncRNAs) due to their multifaceted interactions, complex modulation mechanisms, and potential therapeutic applications. These lncRNAs, carried within extracellular vesicles, play a vital partin tumorigenesis disease progression facilitating communication networks between tumor cells local microenvironment, making them an ideal candidates for use in liquid biopsy approach. However, lncRNAs remain understudied area, especially biology. Therefore this review aims comprehensively explore dynamic interplay various cellular components, including interactions with tumor-stroma, immune modulation, drug resistance mechanisms. Understanding regulatory functions these processes can potentially unveil novel diagnostic markers targets cancer. Additionally, emergence RNA-based therapeutics presents exciting opportunities targeting offering innovative strategies combat improve treatment outcomes. Thus, provides insights into current understanding highlighting crucial roles, evolving landscape interventions. Furthermore, we have also discussed advantage exosomes as carriers development personalized targeted therapy patients.

Language: Английский

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LncRNA HAGLROS promotes breast cancer evolution through miR-135b-3p/COL10A1 axis and exosome-mediated macrophage M2 polarization

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 28, 2024

Long non-coding RNAs (lncRNAs) play an important role in breast cancer progression, but the function of lncRNAs regulating tumor-associated macrophages (TAMs) remains unclear. As carriers lncRNAs, exosomes as mediators communication between cells and tumor microenvironment. In this study, we found that lncRNA HAGLROS was highly expressed tissues plasma exosomes, its high expression related to poor prognosis patients. Functionally, cell-derived exosomal promotes cell proliferation, migration, epithelial-mesenchymal transition (EMT) process angiogenesis by inducing TAM/M2 polarization. Mechanistically, competitively binds miR-135-3p prevent degradation target gene COL10A1. Collectively, these results indicated HAGLROS/miR-135b-3p/COL10A1 axis promoted revealed interactive mechanism TAMs, suggesting may be a potential biomarker therapeutic for cancer.

Language: Английский

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Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 24, 2025

Exosomes, as key mediators of intercellular communication, have been increasingly recognized for their role in the oncogenic processes, particularly facilitating drug resistance. This article delves into emerging evidence linking exosomal lncRNAs to modulation resistance mechanisms cancers such ovarian, cervical, and endometrial cancer. It synthesizes current research findings on how these influence cancer cell survival, tumor microenvironment, chemotherapy efficacy. Additionally, review highlights potential therapeutic strategies targeting lncRNAs, proposing a new frontier overcoming By mapping interface resistance, this aims provide comprehensive understanding that could pave way innovative treatments improved patient outcomes female reproductive system cancers.

Language: Английский

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Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2411 - 2411

Published: Aug. 28, 2023

This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within colorectal cancer (CRC) microenvironment, intersecting domains immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in pathogenesis CRC, immune evasion, treatment response to have crucial implications inflammation serve as promising candidates for novel strategies biomarkers. scrutinizes interaction lncRNAs with Consensus Molecular Subtypes (CMSs) their complex interplay tumor stroma affecting immunity inflammation, conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into relationship between other RNAs, including microRNAs circular mediating cell-to-cell communication CRC microenvironment. Lastly, propose potential manipulate enhance anti-tumor thereby underlining significance devising innovative interventions CRC.

Language: Английский

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Differential expressions and potential clinical values of lncRNAs in the plasma exosomes of rheumatoid arthritis

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 128, P. 111511 - 111511

Published: Jan. 9, 2024

Language: Английский

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TACE plus tyrosine kinase inhibitors and immune checkpoint inhibitors versus TACE plus tyrosine kinase inhibitors for the treatment of patients with hepatocellular carcinoma: a meta-analysis and trial sequential analysis

Hepatology International, Journal Year: 2023, Volume and Issue: 18(2), P. 595 - 609

Published: Oct. 16, 2023

Language: Английский

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The Role of Exosomes in Medical Dermatology: Literature Review and Update

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

ABSTRACT Background Exosomes are extracellular vesicles, composed of a phospholipid bilayer, that primarily derived from stem cells. The contents exosomes can be incorporated into the tissue in which they introduced, presents unique therapeutic option. Aims have been investigated as treatment for number medical ailments, but literature supporting these indications is inconclusive. In addition, much study on and their uses has recently completed. Thus, this review summarizes efficacy implications different dermatologic conditions. Methods A surrounding use multiple dermatological conditions was conducted. Additionally, we present numerous practical cases patients had treated with exosomes. Results Overall, success treating demonstrated varying literature, preliminary evidence generally positive. patient also showed satisfactory clinical outcomes further studies will necessary to fully characterize ideal modalities application, including formulation, mode distribution, frequency treatment. Conclusions may serve an effective option wound healing, reconstruction skin flaps, radiation dermatitis, acne vulgaris, psoriasis, atopic allergic contact lichen simplex chronicus, vulvar sclerosis, systemic lupus erythematosus, vitiligo although additional needed confirm safety.

Language: Английский

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