Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder DOI Creative Commons
Soumyabrata Munshi,

Ahlam M. Alarbi,

Haixia Zheng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 12, 2024

A subset of major depressive disorder (MDD) is characterized by immune system dysfunction, but the intracellular origin these changes remains unclear. Here we tested hypothesis that abnormalities in endoplasmic reticulum (ER) stress, inflammasome activity and mitochondrial biogenesis contribute to development systemic inflammation MDD. RT-qPCR was used measure mRNA expression key organellar genes from peripheral blood mononuclear cells (PBMCs) isolated 186 MDD 67 healthy control (HC) subjects. The comparative CT (2

Language: Английский

Metabolic reprogramming and polarization of microglia in Parkinson’s disease: Role of inflammasome and iron DOI
Haiyang Yu, Qing Chang,

Tong Sun

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 90, P. 102032 - 102032

Published: Aug. 10, 2023

Language: Английский

Citations

59
The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury DOI Open Access
Jie Huang, Lei Chen,

Zi‐Meng Yao

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114671 - 114671

Published: April 8, 2023

Stroke is one of the leading causes death and long-term disability worldwide. More than 80 % strokes are ischemic, caused by an occlusion cerebral arteries. Without question, restoration blood supply as soon possible first therapeutic strategy. Nonetheless paradoxically, reperfusion can further aggravate injury through a series reactions known ischemia-reperfusion (CIRI). Mitochondria play vital role in promoting nerve survival neurological function recovery mitochondrial dysfunction considered characteristics CIRI. Neurons often die due to oxidative stress imbalance energy metabolism following CIRI, there strong association with dysfunction. Altered dynamics reaction stress. Mitochondrial refers maintenance integrity, distribution, size mitochondria well their ability resist external stimuli continuous cycle fission fusion. Therefore, improving means treating This review discusses relationship between CIRI emphasizes potential approach improve prognosis

Language: Английский

Citations

44
Inflammasomes in neurological disorders — mechanisms and therapeutic potential DOI
Kishore Aravind Ravichandran, Michael T. Heneka

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(2), P. 67 - 83

Published: Jan. 9, 2024

Language: Английский

Citations

37
Mitochondrial diseases: from molecular mechanisms to therapeutic advances DOI Creative Commons
Hu Wen,

Hui Deng,

Bingyan Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 9, 2025

Abstract Mitochondria are essential for cellular function and viability, serving as central hubs of metabolism signaling. They possess various metabolic quality control mechanisms crucial maintaining normal activities. Mitochondrial genetic disorders can arise from a wide range mutations in either mitochondrial or nuclear DNA, which encode proteins other contents. These defects lead to breakdown metabolism, such the collapse oxidative phosphorylation, one mitochondria’s most critical functions. diseases, common group disorders, characterized by significant phenotypic heterogeneity. Clinical symptoms manifest systems organs throughout body, with differing degrees forms severity. The complexity relationship between mitochondria diseases results an inadequate understanding genotype-phenotype correlation these historically making diagnosis treatment challenging often leading unsatisfactory clinical outcomes. However, recent advancements research technology have significantly improved our management conditions. translations mitochondria-related therapies actively progressing. This review focuses on physiological mitochondria, pathogenesis potential diagnostic therapeutic applications. Additionally, this discusses future perspectives diseases.

Language: Английский

Citations

4
The Interplay between α-Synuclein and Microglia in α-Synucleinopathies DOI Open Access
Jacob Deyell, Manjari Sriparna, Mingyao Ying

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2477 - 2477

Published: Jan. 27, 2023

Synucleinopathies are a set of devastating neurodegenerative diseases that share pathologic accumulation the protein α-synuclein (α-syn). This causes neuronal death resulting in irreversible dementia, deteriorating motor symptoms, and cognitive decline. While etiology these conditions remains largely unknown, microglia, resident immune cells central nervous system (CNS), have been consistently implicated pathogenesis synucleinopathies. Microglia generally believed to be neuroprotective early stages α-syn contribute further neurodegeneration chronic disease states. molecular mechanisms by which microglia achieve this role still being investigated, here we highlight major findings date. In review, describe how structural varieties inherently disordered result varied microglial receptor-mediated interactions. We also summarize receptors enable cellular recognition uptake α-syn. Lastly, review downstream effects processing within including spread other brain regions neuroinflammation Understanding mechanism interactions with is vital conceptualizing targets for novel therapeutic interventions. addition, given significant diversity pathophysiology synucleinopathies, such gauging all potential pathways state.

Language: Английский

Citations

33
Focusing on mitochondria in the brain: from biology to therapeutics DOI Creative Commons

Nanshan Song,

Shuyuan Mei,

Xiang-Xu Wang

et al.

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: April 17, 2024

Abstract Mitochondria have multiple functions such as supplying energy, regulating the redox status, and producing proteins encoded by an independent genome. They are closely related to physiology pathology of many organs tissues, among which brain is particularly prominent. The demands 20% resting metabolic rate holds highly active mitochondrial activities. Considerable research shows that mitochondria function, while defects induce or exacerbate in brain. In this review, we provide comprehensive advances biology involved functions, well mitochondria-dependent cellular events pathology. Furthermore, various perspectives explored better identify roles neurological diseases neurophenotypes diseases. Finally, therapies discussed. Mitochondrial-targeting therapeutics showing great potentials treatment

Language: Английский

Citations

15
Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products DOI
Kailin Yang,

Liuting Zeng,

Jinsong Zeng

et al.

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102063 - 102063

Published: Sept. 9, 2023

Language: Английский

Citations

17
Resveratrol protects against a high-fat diet-induced neuroinflammation by suppressing mitochondrial fission via targeting SIRT1/PGC-1α DOI
Xiaojuan Su, Qiong Li,

Mingzhi Yang

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 380, P. 114899 - 114899

Published: July 24, 2024

Language: Английский

Citations

7
The role of mitochondrial dynamics in disease DOI Creative Commons
Yujuan Wang, Xinyan Dai, Hui Li

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(6)

Published: Dec. 1, 2023

Mitochondria are multifaceted and dynamic organelles regulating various important cellular processes from signal transduction to determining cell fate. As properties of mitochondria, fusion fission accompanied with mitophagy, undergo constant changes in number morphology sustain mitochondrial homeostasis response context changes. Thus, the dysregulation dynamics mitophagy is unsurprisingly related diseases, but unclear underlying mechanism hinders their clinical application. In this review, we summarize recent developments molecular particularly different roles key components context. We also target treatment diseases cardiovascular system, nervous respiratory tumor metabolism demanding high-energy. these it common that excessive dominant by impaired mitophagy. But there have been many conflicting findings about them recently, which specifically highlighted view. look forward will help broaden our understanding be beneficial discovery novel selective therapeutic targets.

Language: Английский

Citations

13
Social isolation and the risk of Parkinson disease in the UK biobank study DOI Creative Commons
Tingting Geng, Yaqi Li, Yinshun Peng

et al.

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 8, 2024

Abstract Parkinson disease (PD) has become one of the most rapidly growing causes disability among older population and social isolation is a major concern in PD community. However, relationship between future risk remains unclear. This study included 192,340 participants aged 60 or who were free dementia at baseline from UK Biobank study. Social was measured using composite score derived three questions on number household, frequency friend/family visits, leisure/social activities. Incident cases identified through electronic health records. Multivariable-adjusted Cox regression models used to compute hazard ratio (HR) 95% confidence interval (CI). Among (mean [standard deviation] age, 64.2 [2.9] years; 103,253 [53.7%] women), 89,075 (46.3%) least isolated group 26,161 (13.6%) group. Over median follow-up 12.5 years, 2048 incident documented. Compared group, multivariable-adjusted HRs (95% CIs) for 1.00 (0.91−1.10) moderately 1.19 (1.05−1.36) ( P - trend = 0.04). The observed association independent genetic susceptibility consistent subgroup analyses. associated with higher regardless risk. Our findings highlighted importance developing screening intervention strategies adults reduce PD.

Language: Английский

Citations

5