Gasdermin D unlocks metabolic pathways to enhance tissue regeneration DOI
Quazi T.H. Shubhra

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Language: Английский

Bridging the gaps in cancer photothermal therapy through the intersection of nanotechnology and cell membrane coating DOI
Shumin Yang, Huachun Pan, Blassan P. George

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149641 - 149641

Published: Feb. 15, 2024

Language: Английский

Citations

15
At the crossroad of nanotechnology and cancer cell membrane coating: Expanding horizons with engineered nanoplatforms for advanced cancer therapy harnessing homologous tumor targeting DOI
Huachun Pan, Shumin Yang, Lun Gao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215712 - 215712

Published: Feb. 15, 2024

Language: Английский

Citations

14
Allyl methyl disulfide attenuates liver injury induced by concanavalin A by suppressing M1 polarization of macrophages and NLRP3 inflammasome activation DOI
Mingjie Song, Xuan Gao, Dongmei Cheng

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114149 - 114149

Published: Feb. 4, 2025

Language: Английский

Citations

1
GSDMD-mediated mitochondrial dysfunction in marginal cells: A potential driver of inflammation and stria vascularis damage in CIHL DOI Creative Commons

Yu Xiao,

Xiaohan Zhang, Siwei Guo

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(11)

Published: March 11, 2025

Inflammation is among the known causes of cisplatin-induced hearing loss (CIHL), but its exact pathophysiological mechanisms remain unclear. Herein, we demonstrated that pyroptosis—a recently identified inflammatory type regulated cell death dependent on gasdermin D (GSDMD)—was activated in cochleae cisplatin-treated mice, causing CIHL. Meanwhile, treatment with GSDMD inhibitor necrosulfonamide alleviated CIHL these mice. To further examine role GSDMD-mediated pyroptosis CIHL, conducted experiments Gsdmd- deficient mice . Gsdmd −/− significantly lower cochlear damage than control and appeared to be invulnerable Furthermore, stria vascularis (SV), not hair cells (HCs), played a dominant In marginal (MCs) SV, cisplatin induced caspase-dependent cleavage, pore-forming N-terminal rapidly localized mitochondria, leading abnormal mitochondrial aggregation oxidative stress. The consequent dysfunction MCs might result severe progression inflammation, SV damage, HC loss. Notably, pharmacological inhibition using FDA-approved drug disulfiram effectively symptoms Collectively, findings offer broad avenue for inhibiting pyroptosis-induced ototoxicity provide valuable theoretical insights clinical management

Language: Английский

Citations

1
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses DOI
Qiang Cai,

Yihao Tian,

Quazi T.H. Shubhra

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(5), P. 884 - 886

Published: May 1, 2024

Language: Английский

Citations

4
The Mechanisms and Implications of Cardiolipin in the Regulation of Cell Death DOI

Z. Li,

Haijun Xiao, Jiaqi Hu

et al.

Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(3)

Published: March 1, 2025

ABSTRACT Cardiolipin (CL), an exclusive phospholipid, is predominantly found within the confines of inner mitochondrial membrane, playing indispensable role in sustenance operations and regulation cellular energy metabolism. The influence CL on pathways cell death has garnered significant interest recent scholarly discourse. This review delves into multifaceted roles across various modes demise, encompassing apoptosis, autophagy, pyroptosis, ferroptosis, necrosis, necroptosis. discussion extends to examination CL's implications a clinical context, particularly concerning cardiovascular maladies, neurological degeneration, oncological conditions. Through integrative analysis contemporary research findings, aim elucidate intricate dynamics involvement phenomena. While acknowledging inherent limitations hurdles faced by current endeavors, therapeutic potential as modulator nonetheless encouraging. Forthcoming investigations must surmount these obstacles, thereby uncovering nuanced mechanisms impacts realm associated pathologies, potentially paving way for innovative intervention strategies.

Language: Английский

Citations

0
Integrative gas-based therapeutics for cancer treatment: Recent advances and multi-therapy innovations DOI

Jiaqing Zhang,

Xiang Cao,

Huiyun Wen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216746 - 216746

Published: May 2, 2025

Language: Английский

Citations

0
Glaesserella parasuis serotype 5 induces pyroptosis via the RIG-I/MAVS/NLRP3 pathway in swine tracheal epithelial cells DOI
Yuhui Li,

Mengru Guo,

Qīng Wáng

et al.

Veterinary Microbiology, Journal Year: 2024, Volume and Issue: 294, P. 110127 - 110127

Published: May 22, 2024

Language: Английский

Citations

2
New insights into the relationship of mitochondrial metabolism and atherosclerosis DOI
Zizheng Wang, Wei Sun, Kai Zhang

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 127, P. 111580 - 111580

Published: Dec. 27, 2024

Language: Английский

Citations

2
Silk-enriched hydrogels with ROS-scavenging dendrimers for advanced wound care DOI
Md. Robiul Islam, Md. Serajum Manir, Md. Abdur Razzak

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135567 - 135567

Published: Sept. 15, 2024

Language: Английский

Citations

0