Journal of Chemical Neuroanatomy, Journal Year: 2023, Volume and Issue: 132, P. 102304 - 102304
Published: June 17, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2618 - 2618
Published: Feb. 27, 2022
Stress and negative emotions evoked by social relationships working conditions, frequently accompanied the consumption of addictive substances, metabolic and/or genetic predispositions, negatively affect brain function. One affected structures is nucleus accumbens (NAc). Although its function commonly known to be associated with reward responses addiction, a growing body evidence also suggests role in some mental disorders, such as depression schizophrenia, well neurodegenerative diseases, Alzheimer's, Huntington's, Parkinson's. This may result from disintegration extensive connections based on numerous neurotransmitter systems, impairment neuroplasticity mechanisms NAc. The consequences NAc lesions are both morphological functional. They include changes NAc's volume, cell number, modifications neuronal dendritic tree spines, number synapses. Alterations synaptic plasticity efficiency transmission. Modification structure receptors affects signaling pathways, content neuromodulators (e.g., BDNF) transcription factors pCREB, DeltaFosB, NFκB), gene expression. Interestingly, often have different character intensity compared observed other parts basal ganglia, particular dorsal striatum. In this review, we highlight various pathological processes context structural functional damage, impaired areas cooperating within progression processes.
Language: Английский
Citations
34
Metabolites, Journal Year: 2024, Volume and Issue: 14(10), P. 549 - 549
Published: Oct. 14, 2024
Mental health is an increasing topic of focus since more than 500 million people in the world suffer from depression and anxiety. In this multifactorial disorder, parameters such as inflammation, state microbiota and, therefore, patient's nutrition are receiving attention. addition, food products source many essential ingredients involved regulation mental processes, including amino acids, neurotransmitters, vitamins, others. For reason, narrative review was carried out with aim analyzing role anxiety disorders. To reach aim, a critical conducted utilizing both primary sources, scientific publications secondary bibliographic indexes, web pages, databases. The search PsychINFO, MedLine (Pubmed), Cochrane (Wiley), Embase, CinAhl. results show direct relationship between what we eat our nervous system. gut-brain axis complex system which intestinal communicates directly provides it neurotransmitters for its proper functioning. An imbalance due to poor will cause inflammatory response that, if sustained over time together other factors, can lead disorders depression. Changes functions microbiota-gut-brain have been linked several It believed that modulation microbiome composition may be effective strategy new treatment these Modifications nutritional behaviors use ergogenic components presented important non-pharmacological interventions prevention treatment. desirable choice probiotic individual patients based on appropriate biochemical microbiological tests.
Language: Английский
Citations
8
Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 460 - 460
Published: April 9, 2024
The recent approval of formulations the endogenous neurosteroid allopregnanolone (brexanolone) and synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research elucidate why these potent enhancers GABAAR function are clinically effective in this condition. Dopaminergic projections from ventral tegmental area (VTA) nucleus accumbens associated with reward/motivation brain imaging studies report that individuals PPD show reduced activity pathway response reward infant engagement. However, influence neurosteroids on GABA-ergic transmission received limited attention. Here, we investigate, medium spiny neurons (MSNs) mouse core, effect allopregnanolone, other steroids interest fast phasic tonic inhibition mediated by synaptic (α1/2βγ2) extrasynaptic (α4βδ) GABAARs, respectively. We present evidence suggesting resident current results spontaneous opening δ-GABAARs, where steroid-enhanced is GABA-dependent. Furthermore, demonstrate local synthesis accumbal slice preparation reveal neurotransmission MSNs influenced an tone. Given dramatic fluctuations levels during pregnancy postpartum, neurosteroid-mediated fine-tuning GABAergic will probably be perturbed.
Language: Английский
Citations
4
Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4542 - 4542
Published: Oct. 28, 2022
Social isolation (SI) is a major risk factor for mood disorders in adolescents. The nucleus accumbens (NAc) an important reward center implicated psychiatric disorders. Resveratrol (RSV) one of the most effective natural polyphenols with anti-anxiety and depression effects. However, little known about therapeutic effects mechanisms RSV on behavioral abnormality adolescent social stress. Therefore, this study aimed to investigate underlying mechanism amelioration SI-induced abnormality. We found that SI induced anxiety-like behavior dysfunction isolated female rats. Moreover, reduced mitochondrial number ATP levels increased thin spine density NAc. RNA sequencing results showed changed transcription pattern NAc, including 519 upregulated genes 610 downregulated genes, especially those related function. Importantly, ameliorated abnormalities by NAc mitochondria number. Furthermore, activity cytochrome C oxidase (COX) mRNA Cox5a, Cox6a1 Cox7c. These demonstrate modulation plasticity function has effect isolation.
Language: Английский
Citations
11
Current Opinion in Endocrine and Metabolic Research, Journal Year: 2022, Volume and Issue: 24, P. 100333 - 100333
Published: Feb. 20, 2022
Allopregnanolone is an endogenous neurosteroid that acts in a rapid non-genomic manner to enhance the function of GABAA receptor (GABAAR), major inhibitory mammalian central nervous system (CNS). Consequently, allopregnanolone elicits anxiolytic, antidepressant, anticonvulsant, analgesic and sedative effects. Endogenous influences neural inhibition behaviour, with perturbed levels implicated depressive disorders. The approval brexanolone (an formulation) treat postpartum depression (PPD) has encouraged optimism they may provide new approach mood Elucidating how neurosteroids are distinguished from established GABAAR-active drugs, e.g. benzodiazepines, improve understanding disorders aid drug development for psychiatric conditions. Here, we focus on research highlighting: (1) acute interaction GABAARs incorporating δ subunit (δ-GABAAR) (2) additionally act slower time scale expression δ-GABAARs, thereby providing sustained therapeutic benefit.
Language: Английский
Citations
8
Psychological Medicine, Journal Year: 2022, Volume and Issue: 53(11), P. 5203 - 5217
Published: Sept. 19, 2022
Psychosocial stressors characterized by social threat, such as interpersonal loss and rejection, are associated with depression in adolescents. Few studies, however, have examined whether threat affects fronto-cingulate-limbic systems implicated adolescent depression.
Language: Английский
Citations
8
World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(7), P. 1106 - 1117
Published: July 11, 2024
Major depressive disorder (MDD) in adolescents and young adults contributes significantly to global morbidity, with inconsistent findings on brain structural changes from magnetic resonance imaging studies. Activation likelihood estimation (ALE) offers a method synthesize these diverse identify consistent anomalies.
Language: Английский
Citations
1
Expert Opinion on Pharmacotherapy, Journal Year: 2023, Volume and Issue: 24(7), P. 835 - 847
Published: April 19, 2023
Anxiety disorders are the most prevalent psychiatric among youth. Among various anxiety disorders, generalized disorder is particularly prevalent. Youth with GAD appear at elevated risk of developing other mood disorder, and substance use disorders. Functional outcomes youth can be improved through early recognition treatment, thus promoting better longer-term outcomes.
Language: Английский
Citations
3
Psychogeriatrics, Journal Year: 2023, Volume and Issue: 23(4), P. 578 - 587
Published: April 11, 2023
Postoperative cognitive dysfunction (POCD) often occurs in elderly patients, causing depression and other symptoms. Nucleus accumbens (NAc) is involved depression. We investigate the diffusion tensor imaging (DTI) parameters of NAc a POCD model depression.Twenty-month-old male Sprague-Dawley (SD) rats were randomly divided into Sham groups. The group underwent exploratory laparotomy to establish model, while sham operation. fractional anisotropy (FA) mean diffusivity (MD) values bilateral NAc, behavioural changes forced swimming test sucrose preference rate, pathological glial fibrillary acidic protein (GFAP) fluorescent intensity observed at 15 days (D15 ) 30 (D30 after operation.The FA value area was lower than that two time periods operation (P < 0.05). However, MD D30 higher D15 floating prolonged rate decreased compared with longer . GFAP region 0.05).Microstructural are associated related In addition, demonstrated be effective diagnosing monitoring postoperative its severity.
Language: Английский
Citations
0
Journal of Chemical Neuroanatomy, Journal Year: 2023, Volume and Issue: 132, P. 102304 - 102304
Published: June 17, 2023
Language: Английский
Citations
0