Understanding schizophrenia through animal models: The role of environmental stressors DOI Creative Commons
M. Manojlović

Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(6), P. 774 - 795

Published: Jan. 1, 2024

Schizophrenia and other related disorders represent a major clinical challenge, with environmental genetic factors contributing to their occurrence. Animal models are indispensable tools for understanding the complex neurobiological mechanisms underlying psychosis developing new therapeutic approaches. This review focuses on animal commonly used in schizophrenia research, especially those based prenatal postnatal risk factors. Prenatal exposure infections, such as bacterial lipopolysaccharides (LPS) viral components poly I:C, activates immune responses that lead long-lasting structural functional changes brain, including hippocampal atrophy cortical thinning. Postnatal early life stress, social isolation drug abuse, particularly cannabis, also being modelled investigate effects brain development onset of psychosis. These allow controlled manipulation challenges provide insights into aetiology pathophysiology disease. However, variability experimental protocols lack female representation many studies underscore need more robust inclusive models. Ultimately, these crucial better testing potential interventions.

Language: Английский

Mitochondrial dysfunction: A fatal blow in depression DOI Open Access
Yu Song, Huấn Cao, Chengchao Zuo

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115652 - 115652

Published: Oct. 4, 2023

Mitochondria maintain the normal physiological function of nerve cells by producing sufficient cellular energy and performing crucial roles in maintaining metabolic balance through intracellular Ca2+ homeostasis, oxidative stress, axonal development. Depression is a prevalent psychiatric disorder with an unclear pathophysiology. Damage to hippocampal neurons key component plasticity regulation synapses plays critical role mechanism depression. There evidence suggesting that mitochondrial dysfunction associated synaptic impairment. The maintenance homeostasis includes quantitative quality control mitochondria. Mitochondrial biogenesis produces new healthy mitochondria, dynamics cooperates mitophagy remove damaged These processes population stability exert neuroprotective effects against early In contrast, observed various brain regions patients major depressive disorders. accumulation defective mitochondria accelerates dysfunction. addition, impaired aggravate alterations microenvironment, promoting neuroinflammation depletion, thereby exacerbating development This review summarizes influence underlying molecular pathways on pathogenesis Additionally, we discuss as potential therapeutic strategy for

Language: Английский

Citations

51

Bioactive compounds from Chinese herbal plants for neurological health: mechanisms, pathways, and functional food applications DOI Creative Commons
Meng Wang, Chao Wang,

Zhao Kaiwei

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Neurological disorders pose significant global public health challenges, with a rising prevalence and complex pathophysiological mechanisms that impose substantial social economic burdens. Traditional Chinese Medicine (TCM), its holistic approach multi-target effects, has gained increasing attention in the treatment of neurological diseases. This review explores bioactive compounds derived from herbal plants, focusing on their action, underlying pathways, potential applications functional food development. The highlights neuroprotective properties flavonoids, alkaloids, polysaccharides, polyphenols found key TCM herbs such as Scutellaria baicalensis , Salvia miltiorrhiza Ligusticum chuanxiong Gastrodia elata . These have demonstrated anti-inflammatory, antioxidant, neurogenic making them promising candidates for prevention conditions, including Alzheimer’s disease (AD), Parkinson’s (PD), depression. Furthermore, synergistic effects formulations targeting multiple signaling pathways offer advantages over single-target therapies, especially combating neurodegenerative also discusses challenges future directions integrating these into foods dietary supplements, aiming to improve enhance clinical outcomes. Ultimately, this work aims provide valuable insights TCM-based interventions promoting well-being addressing burden disorders.

Language: Английский

Citations

3

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence DOI
Katarzyna Socała, Elżbieta Żmudzka, Klaudia Lustyk

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(3), P. 1400 - 1461

Published: Jan. 17, 2024

Abstract Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for development of new effective therapeutics treat them. Stilbenes, with resveratrol attracting most attention, example multi‐target compounds promising therapeutic potential broad array neuropsychiatric and neurological conditions. This review is comprehensive summary current state research on stilbenes several such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, neurodegenerative disorders. We describe discuss results both vitro vivo studies. The majority studies concentrate resveratrol, limited findings exploring other pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic derivatives. Overall, although extensive preclinical show benefits various central nervous system clinical evidence their efficacy largely missing.

Language: Английский

Citations

12

Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence DOI Open Access
В. Э. Цейликман,

Olga B. Tseilikman,

Oleg N. Yegorov

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2856 - 2856

Published: Aug. 26, 2024

The medicinal properties of resveratrol have garnered increasing attention from researchers. Extensive data been accumulated on its use in treating cardiovascular diseases, immune system disorders, cancer, neurological and behavioral disorders. protective mechanisms resveratrol, particularly anxiety-related stress well documented. However, less has given to the side effects resveratrol. This review explores not only underlying anxiolytic but also that may lead increased anxiety following treatment. Understanding these is crucial for enhancing efficacy managing disorders associated with PTSD.

Language: Английский

Citations

5

The effects of physical activity on glutamate neurotransmission in neuropsychiatric disorders DOI Creative Commons
Richard Baskerville, Thomas McGrath,

L M Castell

et al.

Frontiers in Sports and Active Living, Journal Year: 2023, Volume and Issue: 5

Published: March 6, 2023

Physical activity (PA) is an effective way of increasing cognitive and emotional health counteracting many psychiatric conditions. Numerous neurobiological models for depression have emerged in the past 30 years but struggle to incorporate effects exercise. The hippocampus pre-frontal cortex (PFC) containing predominantly glutamate neurotransmission, are centres changes seen depression. There therefore interest glutamatergic systems which offers new paradigms understanding mechanisms connecting physical activity, stress, inflammation depression, not explained by serotonin theories Similar hippocampal dysfunction observed other neuropsychiatric Excitatory neurones high functionality, also ATP requirements vulnerable glucocorticoid or pro-inflammatory stress that causes mitochondrial dysfunction, with synaptic loss, culminating depressed mood cognition. Exercise improves function, angiogenesis synaptogenesis. Within hypothesis been extensively researched, PA as a mitigator less understood. This review examines underlying evidence interventions within this framework. A dynamic glutamate-based homeostatic model suggested whereby neuroinflammation form counterbalancing influences on cell manifests conditions when homeostasis disrupted.

Language: Английский

Citations

10

Pharmacological mechanism of natural antidepressants: The role of mitochondrial quality control DOI
Shimeng Lv, Guangheng Zhang,

Yitong Lu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155669 - 155669

Published: April 28, 2024

Language: Английский

Citations

3

A genome-wide gene-environmental interaction study identified novel loci for the relationship between ambient air pollution exposure and depression, anxiety DOI Creative Commons
Peilin Meng, Chuyu Pan, Xiaoyue Qin

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117121 - 117121

Published: Oct. 1, 2024

Language: Английский

Citations

3

The Effects of Early-Life Stress on Liver Transcriptomics and the Protective Role of EPA in a Mouse Model of Early-Life-Stress-Induced Adolescent Depression DOI Open Access

Jinlan Zhao,

Lihong Ye,

Zuyi Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13131 - 13131

Published: Aug. 23, 2023

Early-life stress (ELS) was found to increase the risk of adolescent depression, and clinical evidence indicated that eicosapentaenoic acid (EPA) decreased in patients with but underlying mechanisms are unclear. Here, we utilized an ELS model maternal separation early weaning explore protective role EPA depression. We induced depression-like behavior rather than anxiety-like mice. RNA-sequencing results showed changed transcription pattern liver, including 863 upregulated genes 971 downregulated genes, especially those related biosynthesis unsaturated fatty acids metabolism liver. Moreover, expression rate-limiting enzymes, desaturases 1/2 (FADS1/2), involved Additionally, reduced levels serum, hippocampus, administration improved behavior-induced by ELS. Our provide transcriptomic increases depression reducing synthesis EPA, suggest supplementation should be investigated as a potential treatment for

Language: Английский

Citations

6

Social isolation during adolescence causes increased generalised anxiety-like behaviour in male rats and increased sociability in male and female rats DOI Creative Commons
M. Manojlović, F. Milosavljević, A. Atanasov

et al.

Neuroscience Applied, Journal Year: 2024, Volume and Issue: 3, P. 104068 - 104068

Published: Jan. 1, 2024

As one of the main characteristics adolescence is increased desire for social interaction and formation meaningful relationships, it represents a particularly vulnerable period stressors. Moreover, isolation during can significantly alter brain function increase likelihood anxiety disorders in early adulthood. The aim this retrospective meta-analysis prospective behavioural experiment was to investigate whether chronic stress causes generalised anxiety-like behaviour rodents. previously published data showed that leads an exclusively male isolated rodents has ambiguous effect on behaviour. In subsequent experiment, Sprague-Dawley rats both sexes were subjected six weeks their investigated open field, elevated plus maze, three-chamber test. Consistent with literature analysis, males, as indicated by decrease time spent centre field arms compared controls. Both female sociability test, preference ratio versus neutral stimuli, Altogether, males females.

Language: Английский

Citations

2

Si-Ni-San alleviates early life stress-induced depression-like behaviors in adolescence via modulating Rac1 activity and associated spine plasticity in the nucleus accumbens DOI Creative Commons
Lihong Ye,

Jiayi Wu,

Zuyi Liu

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 1, 2023

Background: Early life stress (ELS) is a major risk factor for depression in adolescents. The nucleus accumbens (NAc) key center of the reward system, and spine remodeling NAc contributes to development depression. Si-Ni-San formula (SNS) fundamental prescription treating traditional Chinese medicine. However, little known about effects SNS on behavioral abnormalities plasticity induced by ELS. Purpose: This study aimed investigate therapeutic effect modulatory mechanism abnormal behaviors caused Methods: We utilized model ELS that involved maternal separation with early weaning explore protective adolescent Depressive-like were evaluated sucrose preference test, tail suspension forced swimming test; anxiety-like monitored open field test elevated plus maze. A laser scanning confocal microscope was used analyze dendritic NAc. activity Rac1 detected pull-down Western blot tests. Viral-mediated gene transfer its role ELS-induced depression-like adolescence. Results: but not mice, accompanied an increase stubby density, decrease mushroom decreased Overexpression constitutively active reversed depression-related behaviors, leading density density. Moreover, attenuated behavior mice counteracted Additionally, increased activity, inhibition weakened antidepressant SNS. Conclusion: These results suggest may exert modulating associated

Language: Английский

Citations

5