Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

Nature Reviews Cardiology, Journal Year: 2020, Volume and Issue: 17(9), P. 585 - 607

Published: Feb. 20, 2020

Language: Английский

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International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)

Frontiers in Human Neuroscience, Journal Year: 2021, Volume and Issue: 14

Published: March 23, 2021

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either auricular branch or cervical bundle nerve, referred to as stimulation(VNS) VNS, respectively. In order advance field a systematic manner, studies using these technologies need adequately report sufficient methodological detail enable comparison results between studies, replication well enhancing study participant safety. We systematically reviewed existing literature evaluate current reporting practices. Based on this review, consensus among participating authors, we propose set minimal items guide future studies. The suggested address specific technical aspects device parameters. also cover general recommendations including inclusion exclusion criteria for participants, outcome parameters detailed side effects. Furthermore, review strategies used identify optimal given research setting summarize ongoing developments animal with potential implications application humans. Finally, discuss associated challenges several disciplines practice.

Language: Английский

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Inappropriate sinus tachycardia in post-COVID-19 syndrome

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Jan. 7, 2022

Inappropriate sinus tachycardia (IST) is a common observation in patients with post-COVID-19 syndrome (PCS) but has not yet been fully described to date. To investigate the prevalence and mechanisms underlying IST prospective population of PCS patients. Consecutive admitted Unit between June December 2020 resting rhythm rate ≥ 100 bpm were prospectively enrolled this study further examined by an orthostatic test, 2D echocardiography, 24-h ECG monitoring (heart variability was surrogate for cardiac autonomic activity), quality-of-life exercise capacity testing, blood sampling. assess function, 2:1:1 comparative sub-analysis conducted against both recovered previous SARS-CoV-2 infection individuals without prior infection. Among 200 patients, 40 (20%) fulfilled diagnostic criteria (average age 40.1 ± 10 years, 85% women, 83% mild COVID-19). No structural heart disease, pro-inflammatory state, myocyte injury, or hypoxia identified. accompanied decrease most parameters, especially those related cardiovagal tone: pNN50 (cases 3.2 3 vs. 10.5 8 non-infected 17.3 10; p < 0.001) HF band (246 179 463 295 1048 570, respectively; 0.001). prevalent condition among Cardiac nervous system imbalance decreased parasympathetic activity may explain phenomenon.

Language: Английский

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Refractory Angina

КАРДИОЛОГИЯ УЗБЕКИСТАНА, Journal Year: 2020, Volume and Issue: 13(1), P. 1 - 19

Published: Jan. 1, 2020

Language: Английский

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Alteration of Autonomic Nervous System Is Associated With Severity and Outcomes in Patients With COVID-19

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: May 19, 2021

Background Previous studies suggest that coronavirus disease 2019 (COVID-19) is a systemic infection involving multiple systems, and may cause autonomic dysfunction. Objective To assess function relate the findings to severity outcomes in COVID-19 patients. Methods We included consecutive patients with admitted 21st Department of east campus Renmin Hospital Wuhan University from February 6 March 7, 2020. Clinical data were collected. Heart rate variability (HRV), N-terminal pro-B-type natriuretic peptide (NT-proBNP), D -dimer, lymphocytes subsets counts analysed at two time points: nucleic-acid test positive negative. Psychological symptoms assessed after discharge. Results All divided into mild group (13) severe (21). The latter was further categories according trend HRV. Severe had significantly lower standard deviation RR intervals (SDNN) ( P &lt; 0.001), averages NN (SDANN) higher ratio low- high-frequency power (LF/HF) = 0.016). Linear correlations shown among SDNN, SDANN, LF/HF, laboratory indices 0.05). Immune function, NT-proBNP showed consistent HRV 0.05), without improved parameters needed longer clear virus recover Conclusion associated COVID-19. changing related prognosis, indicating measurements can be used as non-invasive predictor for clinical outcome.

Language: Английский

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Cardiac Autonomic Neuropathy in Type 1 and 2 Diabetes: Epidemiology, Pathophysiology, and Management

Clinical Therapeutics, Journal Year: 2022, Volume and Issue: 44(10), P. 1394 - 1416

Published: Oct. 1, 2022

PurposeCardiac autonomic neuropathy (CAN) is a serious complication of type 1 and 2 diabetes independently associated with major cardiovascular events, morbidity, mortality. This narrative review examines the epidemiology, pathophysiology, management identifies areas future research to address challenge posed by CAN.MethodsWe conducted comprehensive literature search using range sources, including electronic databases PubMed Central, Google Scholar, OVID, Open Athens, for studies on CAN, mellitus, lifestyle intervention, risk. We set inclusion criteria consider articles or original published in peer-reviewed journals that examined CAN diabetes.FindingsEpidemiologic data indicate varied prevalence diabetes, prevalences 17% 73%) depending clinical demographic factors. Indeed, duration hyperglycemia are strongest risk factors development diabetes. However, multifactorial factors, obesity, hypertension, hyperlipidemia, CAN. Insulin resistance, which underpins metabolic syndrome, has direct role pathogenesis Lifestyle interventions, dietary measures tailored exercise programs, have been beneficial improving cardiac function primarily measured through heart rate variability. In addition, weight loss bariatric surgery also improves variability may prevent reduce progression people living obesity concomitant For optimization both targeted pharmacologic interventions required achieve glycemic/metabolic targets, reverse early definite severe CAN.ImplicationsThe focused use diagnostic testing reflex those at high will enable earlier diagnosis. allow timely reversible stage. Future should examine subsequent intervention combination newer pharmacotherapeutics (eg, sodium-glucose cotransporter inhibitors glucagon-like peptide receptor agonists), produced significant benefit

Language: Английский

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Cardiac Arrhythmias in Post-COVID Syndrome: Prevalence, Pathology, Diagnosis, and Treatment

Viruses, Journal Year: 2023, Volume and Issue: 15(2), P. 389 - 389

Published: Jan. 29, 2023

An increase in post-COVID patients with late sequelae of acute COVID-19 infection is emerging as an ongoing challenge for physicians and healthcare professionals. Since the beginning pandemic, it has rapidly become evident that not limited to respiratory tract but several organs, including cardiovascular system, can be affected. Moreover, a significant proportion (ranging from about 10 up 50%) former COVID-19, cardiopulmonary symptoms such dyspnea, palpitations, restricted physical capacity, cardiac arrhythmias persist weeks months after SARS-CoV-2 infection. The spectrum COVID-19-associated rather wide, most likely due various pathomechanisms. In this article, prevalence underlying pathologies are reviewed, direct myocardial injury abnormal consequences impact on electric instability. hyperinflammatory reaction host immune system specifically considered. distinct rhythm disorders occurring discussed regard their clinical management.

Language: Английский

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Cardioneuroablation: Where are we at?

Heart Rhythm O2, Journal Year: 2023, Volume and Issue: 4(6), P. 401 - 413

Published: March 21, 2023

Language: Английский

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Exploring the Complex Relationship between Diabetes and Cardiovascular Complications: Understanding Diabetic Cardiomyopathy and Promising Therapies

Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1126 - 1126

Published: April 7, 2023

Diabetes mellitus (DM) and cardiovascular complications are two unmet medical emergencies that can occur together. The rising incidence of heart failure in diabetic populations, addition to apparent coronary disease, ischemia, hypertension-related complications, has created a more challenging situation. Diabetes, as predominant cardio-renal metabolic syndrome, is related severe vascular risk factors, it underlies various complex pathophysiological pathways at the molecular level progress converge toward development cardiomyopathy (DCM). DCM involves several downstream cascades cause structural functional alterations heart, such diastolic dysfunction progressing into systolic dysfunction, cardiomyocyte hypertrophy, myocardial fibrosis, subsequent over time. effects glucagon-like peptide-1 (GLP-1) analogues sodium-glucose cotransporter-2 (SGLT-2) inhibitors on (CV) outcomes diabetes have shown promising results, including improved contractile bioenergetics significant benefits. purpose this article highlight pathophysiological, metabolic, contribute its cardiac morphology functioning. Additionally, will discuss potential therapies may be available future.

Language: Английский

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Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 1, 2023

Long COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at higher risk of COVID. Heart rate variability imbalances in individuals suffering from COVID, measurement non-invasive low-cost method assessing modulation. Additionally, biochemical markers are diagnosing monitoring These improve understanding driving response its effects on sympathetic parasympathetic pathways nervous system. Autonomic may result lower heart variability, impaired vagal activity, substantial sympathovagal imbalance. New research subject must encouraged enhance long-term risks cause

Language: Английский

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