Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 20, 2023

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays prominent role in cardiovascular diseases. From research history milestone events related to hypoxia development diseases, The "hypoxia-inducible factors (HIFs) switch" can be observed from both temporal spatial perspectives, encompassing occurrence progression (gradual decline concentration), acute chronic manifestations hypoxia, geographical characteristics (natural selection at high altitudes). Furthermore, signaling pathways are associated with natural rhythms, such as diurnal hibernation processes. In addition innate selection, it has been found epigenetics, postnatal factor, profoundly influences hypoxic response within system. Within this intricate process, interactions between different tissues organs system other systems context have established. Thus, time summarize construct multi-level regulatory framework mechanisms diseases for developing more therapeutic targets make reasonable advancements clinical research, including FDA-approved drugs ongoing trials, guide future practice field

Language: Английский

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Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3392 - 3392

Published: Feb. 8, 2023

Availability of artificial light and light-emitting devices have altered human temporal life, allowing 24-hour healthcare, commerce production, expanding social life around the clock. However, physiology behavior that evolved in context 24 h solar days are frequently perturbed by exposure to at night. This is particularly salient circadian rhythms, result endogenous biological clocks with a rhythm ~24 h. Circadian rhythms govern features behavior, set precisely primarily during day, though other factors, such as timing meals, can also affect rhythms. significantly affected night shift work because nocturnal light, electronic devices, shifts meals. Night workers increased risk for metabolic disorder, well several types cancer. Others who exposed or late mealtimes show disrupted cardiac disorders. It imperative understand how alter function develop strategies mitigate their negative effects. In this review, we provide an introduction physiological regulation homeostasis suprachiasmatic nucleus (SCN), SCN-mediated hormones display including melatonin glucocorticoids. Next, discuss circadian-gated processes sleep food intake, followed modern lighting disrupts molecular clock Lastly, identify disruptions metabolism increase susceptibility syndrome cardiovascular diseases, various harmful consequences associated on health.

Language: Английский

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Zishenhuoxue decoction-induced myocardial protection against ischemic injury through TMBIM6-VDAC1-mediated regulation of calcium homeostasis and mitochondrial quality surveillance

Phytomedicine, Journal Year: 2023, Volume and Issue: 132, P. 155331 - 155331

Published: Dec. 31, 2023

Language: Английский

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Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2

Circulation, Journal Year: 2022, Volume and Issue: 146(21), P. 1591 - 1609

Published: Nov. 21, 2022

Background: Metabolic disorder increases the risk of abdominal aortic aneurysm (AAA). NRs (nuclear receptors) have been increasingly recognized as important regulators cell metabolism. However, role in AAA development remains largely unknown. Methods: We analyzed expression profile NR superfamily tissues and identified NR1D1 (NR subfamily 1 group D member 1) most highly upregulated tissues. To examine formation, we used vascular smooth muscle (VSMC)–specific, endothelial cell–specific, myeloid cell–specific conditional Nr1d1 knockout mice both AngII (angiotensin II)– CaPO 4 -induced models. Results: gene exhibited highest fold change among all 49 tissues, protein was human murine VSMCs from The but not cells inhibited formation AngII- Mechanistic studies ACO2 (aconitase-2), a key enzyme mitochondrial tricarboxylic acid cycle, direct target trans-repressed by that mediated regulatory effects on deficiency restored dysregulation dysfunction at early stage infusion before formation. Supplementation with αKG (α-ketoglutarate, downstream metabolite ACO2) beneficial preventing treating manner required VSMCs. Conclusions: Our data define previously unrecognized nuclear receptor pathogenesis an undescribed NR1D1-ACO2 axis involved regulating metabolism It is our findings suggest supplementation effective therapeutic approach for treatment.

Language: Английский

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Effect of dapagliflozin on the prognosis of patients with acute myocardial infarction undergoing percutaneous coronary intervention

Cardiovascular Diabetology, Journal Year: 2022, Volume and Issue: 21(1)

Published: Sept. 16, 2022

The effect of dapagliflozin (DAPA) on the prognosis patients with acute myocardial infarction (AMI) is unclear. present study was conducted to evaluate association between DAPA administration and adverse events in AMI undergoing percutaneous coronary intervention (PCI).This single-center retrospective analysis included a total 786 from January 2019 August 2021 who were or not administered at discharge. primary endpoint composite major cardiovascular (MACE), including overall deaths, heart failure, nonfatal MI, stroke, unplanned repeat revascularization (URR). Differences triglyceride glucose (TyG) index atherogenic plasma (AIP) both during hospitalization 12 months after discharge (if achievable) also compared.During median follow-up 23 months, 130 had MACE (118 DAPA-free group group). Kaplan-Meier survival analyses revealed that cumulative incidence (log-rank test, p = 0.009), failure (p 0.003), MI 0.005), URR 0.031) higher group. In addition, multivariate Cox showed significantly associated reduced risk (hazard ratio 0.170, 95% confidence interval 0.078-0.373, < 0.001). Considering each specific event, regression analyses. Stratification suggested has strong protective advanced age concomitant diabetes those are angiotensin receptor enkephalinase inhibitors. Furthermore, TyG AIP lower than hospitalization.DAPA an independent factor against may provide incremental prognostic information PCI.

Language: Английский

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Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury

Circulation, Journal Year: 2023, Volume and Issue: 148(24), P. 1958 - 1973

Published: Nov. 8, 2023

Reducing cardiovascular disease burden among women remains challenging. Epidemiologic studies have indicated that polycystic ovary syndrome (PCOS), the most common endocrine in of reproductive age, is associated with an increased prevalence and extent coronary artery disease. However, mechanism through which PCOS affects cardiac health unclear.

Language: Английский

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LXRα Promotes Abdominal Aortic Aneurysm Formation Through UHRF1 Epigenetic Modification of miR-26b-3p

Circulation, Journal Year: 2024, Volume and Issue: 150(1), P. 30 - 46

Published: April 1, 2024

Abdominal aortic aneurysm (AAA) is a severe disease without effective pharmacological approaches. The nuclear hormone receptor LXRα (liver X α), encoded by the

Language: Английский

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Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Epidemiology and current management of cardiovascular disease in China

Journal of Geriatric Cardiology, Journal Year: 2024, Volume and Issue: 21(4), P. 387 - 406

Published: April 1, 2024

The Annual Report on Cardiovascular Health and Diseases in China (2022) intricate landscape of cardiovascular health China. This is the fourth section report with a specific focus epidemiology current management disease (CVD) highlights epidemiological trends CVD It reveal concerning rise prevalence, approximately 330 million affected individuals, including significant numbers stroke, coronary artery (CAD), heart failure, other conditions. stands as primary cause mortality among both urban rural populations, accounting for nearly half all deaths 2020. Mortality rates are notably higher areas compared to centers since 2009. While age-standardized have decreased, absolute number has increased, primarily due population aging. Ischemic disease, hemorrhagic ischemic strokes leading causes CVD-related deaths. Notably, burden atherosclerotic risen substantially, disease-related increasing from 1990 2016. incidence stroke shown similar over past three decades. CAD mortality, particularly acute myocardial infarction, been rise, observed prevalence increased significantly, 11 patients identified 2013. Studies assessing hospital performance managing syndrome gaps adherence guideline-recommended strategies, disparities care quality across hospitals. However, initiatives like China Patient-centered Evaluative Assessment Cardiac Events (PEACE)-Retrospective AMI Study Improving Care Disease China-Acute Coronary Syndrome (CCC-ACS) project aim improve patient outcomes through enhanced protocols. Moreover, advancements medical technology, such quantitative flow ratio-guided lesion selection during percutaneous intervention, show promise improving clinical undergoing intervention.

Language: Английский

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Circadian Effects on Vascular Immunopathologies

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 791 - 809

Published: March 14, 2024

Circadian rhythms exert a profound impact on most aspects of mammalian physiology, including the immune and cardiovascular systems. Leukocytes engage in time-of-day–dependent interactions with vasculature, facilitating emigration to surveillance tissues. This review provides an overview circadian control immune-vascular both steady state diseases such as atherosclerosis infarction. vascular facets these interactions, primarily through regulation chemoattractant adhesion molecules endothelial cells. Misaligned light conditions disrupt this rhythm, generally exacerbating In diseases, distinct clock genes, while functioning part integrated system, can have proinflammatory or anti-inflammatory effects interactions. Here, we discuss mechanisms relevance immunopathologies.

Language: Английский

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