Médecine des Maladies Métaboliques,
Journal Year:
2023,
Volume and Issue:
17(8), P. 8S60 - 8S68
Published: Dec. 1, 2023
Les
maladies
cardiovasculaires,
qui
englobent
l'insuffisance
cardiaque,
la
cardiopathie
ischémique,
l'accident
vasculaire
cérébral
(AVC)
et
l'hypertension
artérielle,
concernent
près
d'un
diabétique
sur
deux.
L'incidence
de
maladie
cardiovasculaire
est
croissante
en
fonction
l'âge.
La
mortalité
liée
à
l'atteinte
surpasse
celle
du
cancer.
L'insuffisance
cardiaque
l'une
des
complications
cardiovasculaires
plus
fréquente
chez
le
patient
diabétique.
Le
diagnostic
compliqué
personne
âgée
tandis
que
traitement
médicamenteux
s'est
structuré
dans
les
nouvelles
recommandations.
Cette
polymédication
requiert
quelques
précautions
une
population
âgée.
ischémique
survient
moyenne
autour
70
ans
patients
diabétiques
diabète
indépendamment
associé
mortalité.
dépistage
l'ischémie
myocardique
silencieuse
(IMS)
difficile
codifier
fait
appel
aux
mêmes
médicaments
jeune
modalités
revascularisation
font
l'objet
d'une
décision
collégiale
incluant
gériatre
quand
c'est
possible.
L'accident
cérébral,
facteur
risque
majeur
dépendance,
source
handicap
40
%
cas.
Sa
prise
charge
son
recommandations
qu'il
faut
appliquer
sujet
âgé.
médicale
partagée
primordiale.
Cardiovascular
disease,
which
includes
heart
failure,
ischaemic
stroke
and
high
blood
pressure,
affects
almost
half
of
diabetic
patients.
The
incidence
cardiovascular
disease
increases
with
age.
Mortality
from
exceeds
that
Heart
failure
is
one
the
most
frequent
in
Diagnosis
more
complicated
elderly
than
younger
patients,
while
drug
treatment
for
has
been
structured
new
recommendations.
This
polymedication
requires
a
number
precautions
to
be
taken
an
population.
Ischemic
occurs
around
years
age
diabetes
independently
associated
mortality.
Screening
silent
myocardial
ischemia
difficult
codify.
Medical
ischemic
uses
same
drugs
as
revascularization
procedures
are
decided
on
teams,
including
geriatrician
whenever
Stroke,
major
risk
factor
dependency,
disability
cases.
There
recommendations
management
Shared
medical
decision-making
essential.
Future Science OA,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 31, 2025
To
evaluate
the
analgesic
and
neuroprotective
effects
of
cytidine,
uridine,
gabapentin-administered
alone
in
combination-in
models
diabetic
neuropathy
formalin-induced
acute
inflammatory
pain.
Oral
doses
gabapentin
(100
mg/kg
each)
were
administered
to
rats
with
streptozotocin-induced
a
formalin
test
model.
Behavioral
responses
recorded
at
30,
60,
120
minutes
following
treatment
after
five
weeks
diabetes
induction.
Spinal
cord
p-CREB
expression
was
measured
assess
molecular
changes,
pretreatments
naloxone,
yohimbine,
methysergide
employed
explore
opioid,
adrenergic,
serotonergic
contributions.
All
treatments
significantly
reduced
pain
both
phases
(p
<
0.05;
p
0.001)
increased
mechanical
thresholds
model
all-time
points
0.05).
Combination
therapy
proved
more
effective
than
0.05)
associated
decreased
spinal
levels,
indicating
altered
anti-nociceptive
signaling.
The
combined
use
enhances
analgesia
neuroprotection
compared
monotherapy,
supporting
its
potential
as
novel,
analgesic-free
strategy
for
neuropathy.
Cancer,
Journal Year:
2024,
Volume and Issue:
130(16), P. 2795 - 2806
Published: April 25, 2024
Prediabetes,
which
is
a
precedent
of
overt
diabetes,
known
risk
factor
for
adverse
cardiovascular
outcomes.
Its
impact
on
outcomes
in
patients
with
cancer
who
are
prescribed
anthracycline-containing
chemotherapy
(ACT)
uncertain.
The
objective
this
study
was
to
evaluate
the
association
prediabetes
events
ACT.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 30, 2024
Abstract
Heart
failure
(HF)
is
one
of
the
most
strongly
associated
adverse
cardiovascular
events
linked
to
use
cyclooxygenase
(COX)-2
selective
and
non-selective
nonsteroidal
anti-inflammatory
drug
(NSAID).
Nevertheless,
it
remains
uncertain
whether
NSAID
exposure
more
likely
lead
heart
with
reduced
ejection
fraction
(HFrEF)
or
preserved
(HFpEF).
In
adult
mice,
postnatal
genetic
deletion
pharmacological
inhibition
COX-2
did
not
affect
cardiac
function.
contrast,
aged
female
inducible
(iCOX-2)
knockout
(KO)
mice
displayed
diastolic
dysfunction,
hypertrophy,
pulmonary
congestion,
elevated
levels
plasma
N-terminal
pro
B-type
natriuretic
peptide
(BNP)
when
compared
age-
sex-
matched
controls,
while
their
(EF)
remained
(≥
50%).
No
such
phenotype
was
observed
in
male
iCox-2
KO
mice.
Aged
showed
a
shift
from
prostanoid
leukotriene
biosynthesis,
along
changes
expression
mitochondrial
genes
calcium-handling
proteins
myocardium.
The
ratio
phospholamban
SERCA2a
increased,
indicating
an
inhibitory
effect
on
activity,
which
may
contribute
impaired
myocardial
relaxation.
larval
zebrafish,
by
celecoxib
caused
modest
yet
significant
reduction
rate
function,
EF
preserved.
Additionally,
increased
BNP
ventricular
calcium
transient
amplitude.
Diabetic
patients
Harvard-Partners
electronic
medical
record
exposed
NSAIDs
for
were
risk
HFpEF
HFrEF.
Collectively,
these
findings
indicate
that
does
impair
systolic
function
but
instead
leads
humans.
An
imbalance
handling
mediate
impairment
relaxation
following
suppression.
Summary
Genetic
results
across
Revista Arbitrada Interdisciplinaria de Ciencias de la Salud Salud y Vida,
Journal Year:
2024,
Volume and Issue:
8(1), P. 177 - 183
Published: Feb. 1, 2024
Objetivo:
analizar
el
manejo
clínico
dentro
de
una
cirugía
terceros
molares
en
paciente
femenina
que
presenta
alergias
a
medicamentos
antiinflamatorios
no
esteroides
(AINES)
identificando
la
dirección
erupción
base
estudios
radiográficos.
Método:
Descriptiva
observacional
documental.
Resultados
y
conclusión:
Se
determina
uso
tramadol
37.5
mg
conjunto
con
125
paracetamol,
3
veces
al
día
durante
días,
será
tratamiento
adecuado
para
este
caso
particular.
La
combinación
bajas
dosis
opioides
AINES
tolerados
por
paciente,
permiten
evitar
las
reacciones
adversas
efectos
secundarios
provocados
los
mismos.
