Annual Review of Genomics and Human Genetics,
Journal Year:
2024,
Volume and Issue:
25(1), P. 329 - 351
Published: Aug. 27, 2024
Clonal
hematopoiesis
(CH)
is
an
age-related
process
whereby
hematopoietic
stem
and
progenitor
cells
(HSPCs)
acquire
mutations
that
lead
to
a
proliferative
advantage
clonal
expansion.
The
most
commonly
mutated
genes
are
epigenetic
regulators,
DNA
damage
response
genes,
splicing
factors,
which
essential
maintain
functional
HSPCs
frequently
involved
in
the
development
of
hematologic
malignancies.
Established
risk
factors
for
CH,
including
age,
prior
cytotoxic
therapy,
smoking,
increase
acquiring
CH
and/or
may
fitness.
has
emerged
as
novel
factor
many
diseases,
such
malignancies,
cardiovascular
disease,
diabetes,
autoimmune
disorders,
among
others.
Future
characterization
mechanisms
driving
evolution
will
be
critical
develop
preventative
therapeutic
approaches.
Hämostaseologie,
Journal Year:
2024,
Volume and Issue:
44(01), P. 013 - 020
Published: Feb. 1, 2024
Abstract
Acquired
mutations
that
lead
to
clonal
hematopoiesis
have
emerged
as
a
new
and
potent
risk
factor
for
atherosclerotic
cardiovascular
disease
other
conditions.
Human
sequencing
studies
experiments
in
mouse
models
provide
compelling
evidence
supporting
this
condition,
particularly
when
driven
by
specific
mutated
genes,
contributes
the
development
of
atherosclerosis
exacerbating
inflammatory
responses.
The
insights
gained
from
these
are
paving
way
personalized
preventive
care
strategies
against
disease.
Furthermore,
available
also
suggests
potential
relevance
mutation
context
thrombosis,
an
area
requiring
thorough
investigation.
In
review,
we
overview
our
current
understanding
emerging
factor,
focusing
on
its
relationship
thrombosis.
Annual Review of Genomics and Human Genetics,
Journal Year:
2024,
Volume and Issue:
25(1), P. 329 - 351
Published: Aug. 27, 2024
Clonal
hematopoiesis
(CH)
is
an
age-related
process
whereby
hematopoietic
stem
and
progenitor
cells
(HSPCs)
acquire
mutations
that
lead
to
a
proliferative
advantage
clonal
expansion.
The
most
commonly
mutated
genes
are
epigenetic
regulators,
DNA
damage
response
genes,
splicing
factors,
which
essential
maintain
functional
HSPCs
frequently
involved
in
the
development
of
hematologic
malignancies.
Established
risk
factors
for
CH,
including
age,
prior
cytotoxic
therapy,
smoking,
increase
acquiring
CH
and/or
may
fitness.
has
emerged
as
novel
factor
many
diseases,
such
malignancies,
cardiovascular
disease,
diabetes,
autoimmune
disorders,
among
others.
Future
characterization
mechanisms
driving
evolution
will
be
critical
develop
preventative
therapeutic
approaches.
