BMC Cardiovascular Disorders,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 8, 2025
Patients
with
atrial
fibrillation
are
at
risk
for
various
complications,
including
thromboembolic
events.
This
study
involves
developing
and
evaluating
a
Clinical
Decision
Support
System
(CDSS)
to
select
appropriate
anticoagulant
drug,
considering
comorbidities,
laboratory
data,
concurrent
medications.
The
system
is
based
on
streamlined
interpretation
of
the
most
recent
globally
accepted
clinical
guidelines.
Primarily
semi-structured
interview
regarding
challenges
in
field
thromboprophylaxis
AF
pharmacists
cardiologists'
needs
practice
was
conducted.
Then
required
data
were
extracted
from
latest
guidelines
confirmed
by
expert
panel.
Using
Microsoft
Visio
software
each
scenario
its
corresponding
rules
modeled.
Dart
programming
language,
Flutter
framework,
Visual
Studio
editor
used
develop
application.
Finally,
uMARS
questionnaire
evaluate
application
quality.
selection
anticoagulants
reported
be
challenging
domain
78.6%
participants
interview.
According
designed
algorithms,
developed
using
Asp.net
SQL
Server
database
platform.
CDSS
called
ACAFiB-APP,
which
stands
Anticoagulant
Application.
user
goes
through
calculators
obtains
moreover,
will
choose
one
or
more
comorbidities/clinical
scenarios.
ACAFiB-APP
represent
proper
options
dosing
related
considerations.
All
sections
received
acceptable
scores.
facilitate
informed
complicated
cases
patient
scenario.
Not
applicable.
European Radiology,
Journal Year:
2024,
Volume and Issue:
34(7), P. 4273 - 4283
Published: Jan. 4, 2024
Abstract
Objectives
To
determine
the
diagnostic
accuracy
of
ultra-high-resolution
photon-counting
detector
CT
angiography
(UHR
PCD-CTA)
for
evaluating
coronary
stent
patency
compared
to
invasive
(ICA).
Methods
Consecutive,
clinically
referred
patients
with
prior
implantation
were
prospectively
enrolled
between
August
2022
and
March
2023
underwent
UHR
PCD-CTA
(collimation,
120
×
0.2
mm).
Two
radiologists
independently
analyzed
image
quality
in-stent
lumen
using
a
5-point
Likert
scale,
ranging
from
1
(“excellent”)
5
(“non-diagnostic”),
assessed
all
stents
presence
stenosis
(≥
50%
narrowing).
The
was
determined,
ICA
serving
as
standard
reference.
Results
A
total
44
in
18
participants
(mean
age,
83
years
±
6
[standard
deviation];
12
women)
included
analysis.
In
3/44
stents,
both
readers
described
non-diagnostic,
whereas
reader
2
noted
fourth
have
non-diagnostic
quality.
comparison
ICA,
demonstrated
sensitivity,
specificity,
100%
(95%
CI
[confidence
interval]
47.8,
100),
92.3%
79.1,
98.4),
93.2%
81.3,
98.6)
87.2%
72.6,
95.7),
88.6%
75.4,
96.2)
2,
respectively.
Both
observed
negative
predictive
value
(36/36
34/34
stents).
Stent
inter-reader
agreement
90.1%,
corresponding
substantial
Cohen’s
kappa
0.72.
Conclusions
enables
non-invasive
assessment
high
accuracy.
Clinical
relevance
statement
Ultra-high-resolution
represents
reliable
method
assessing
patency.
Its
makes
it
promising
alternative
over
rule-out
stenosis.
Key
Points
•
CT-based
evaluation
is
limited
by
stent-induced
artifacts
spatial
resolution.
accurately
evaluates
angiography.
Photon-counting
European Heart Journal,
Journal Year:
2024,
Volume and Issue:
45(27), P. 2362 - 2376
Published: June 6, 2024
Abstract
During
the
past
30
years,
several
developments
have
occurred
in
antiplatelet
field,
including
role
of
aspirin
primary
prevention
atherosclerotic
cardiovascular
disease.
There
been
attempts
to
develop
drugs
more
effective
and
safer
than
a
shift
emphasis
from
efficacy
safety,
advocating
aspirin-free
regimens
after
percutaneous
coronary
intervention.
Evidence
supporting
chemopreventive
effect
low-dose
against
colorectal
(and
other
digestive
tract)
cancer
has
also
strengthened.
The
aim
this
article
is
revisit
atherothrombosis
across
risk
continuum,
view
field.
review
will
offer
clinical
perspective
on
aspirin’s
mechanism
action,
pharmacokinetics,
pharmacodynamics.
This
be
followed
by
detailed
discussion
its
safety.
JAMA Cardiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Patients
with
angina
and
no
obstructive
coronary
artery
disease
frequently
have
vasomotor
dysfunction
as
underlying
pathophysiological
mechanism,
comprising
epicardial
spasm,
microvascular
and/or
microcirculatory
dysfunction.
These
endotypes
can
be
diagnosed
by
invasive
function
testing
which
has
previously
shown
to
safe
in
tertiary
expert
centers.
To
determine
the
prevalence
of
patients
who
were
clinically
referred
for
a
test
(CFT);
assess
safety
feasibility
CFT.
This
quality
improvement
study
was
performed
using
Netherlands
Registry
Invasive
Coronary
Vasomotor
Function
Testing
(NL-CFT),
prospective,
observational
registry,
15
participating
hospitals
(2
13
nontertiary).
indicated
CFT
between
December
2020
January
2024
included.
A
complete
consisted
acetylcholine
spasm
provocation
assessment
function.
Prevalence
different
based
on
results
overall
assessed.
Among
total
1207
included,
978
(81%)
female;
mean
(SD)
age
60
(10)
years.
The
very
high
(78%).
There
11
(0.9%)
major
10
(0.8%)
minor
complications
reported.
Of
them,
3
all
definitely
related
test.
No
procedural
death,
myocardial
infarction,
or
stroke
observed.
differences
found
occurrence
nontertiary
that
feasible
perform
both
centers
diagnostic
yield.
