Oxygen‐Independent Photodynamic Therapy‐Mediated Selective Consumption of M1 Macrophage Against Ventricular Arrhythmias via Sympathetic Neuromodulation DOI Open Access
Heng Lin, Hengyang Liu,

Haosong Xi

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract The occurrence of myocardial infarction (MI)‐induced malignant ventricular arrhythmias (VAs) is closely associated with the hyperactivation left stellate ganglion (LSG). Proinflammatory M1 macrophage reported to aggravate sympathetic overactivation and cause VAs. Therefore, depletion anticipated inhibit LSG alleviate MI‐induced Herein, oxygen‐independent photodynamic therapy (Oi‐PDT) combined targeting applied selectively deplete in further treat Oi‐PDT, which overcomes limitation extremely dependence on oxygen content traditional PDT, constructed through generation oxidizing photogenerated holes (h + ) under irradiation near‐infrared (NIR) light prepared Oi‐PDT agent (PPSCD). Meanwhile, PPSCD targets conjunction SR‐A receptor. selective consumption attributed both apoptosis ferroptosis induced by h , 1 O 2 •− generated Oi‐PDT. In vivo tests indicated neural activity experienced a notable reduction from 104.5 ± 2.9 51.5 6.7 after MI treatment, thereby significantly inhibited implementation this study provides promising strategy for macrophages treatment VAs MI.

Language: Английский

Atrial Cardiomyopathy Revisited - Evolution of a Concept. A Clinical Consensus Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Association (APHRS), and the Latin American Heart Rhythm Society (LAHRS) DOI Creative Commons
Andreas Goette, Domenico Corradi, Dobromir Dobrev

et al.

EP Europace, Journal Year: 2024, Volume and Issue: 26(9)

Published: July 30, 2024

Abstract Aims The concept of “atrial cardiomyopathy” (AtCM) had been percolating through the literature since its first mention in 1972. Since then, publications using term were sporadic until decision was made to convene an expert working group with representation from four multinational arrhythmia organizations prepare a consensus document on atrial cardiomyopathy 2016 (EHRA/HRS/APHRS/SOLAECE cardiomyopathies: definition, characterization, and clinical implication). Subsequently, AtCM have increased progressively. Methods results present elaborates further implement simple staging system (AtCM stages 1–3) by integrating biomarkers, geometry, electrophysiological changes. However, proposed needs validation. Importantly, it is clearly stated that presence might serve as substrate for development fibrillation (AF) AF may accelerates substantially, but per se be viewed separate entity. Conclusion Thus, serves statement European Heart Rhythm Association (EHRA) ESC, Society (HRS), Asian Pacific (APHRS), Latin American (LAHRS) contribute evolution concept.

Language: Английский

Citations

41
Natural Products Alleviate Atrial Fibrillation by Modulating Mitochondrial Quality Control DOI

Teng Ge,

Rongjun Zou, Miao Zhang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156555 - 156555

Published: Feb. 22, 2025

Language: Английский

Citations

0
The Role of Cardiac Magnetic Resonance in Characterizing Atrial Cardiomyopathy and Guiding Substrate Ablation in Atrial Fibrillation: A Narrative Review DOI Creative Commons
Jean Pierre Jabbour,

Marta Palombi,

Michela Bonanni

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2025, Volume and Issue: 12(4), P. 114 - 114

Published: March 25, 2025

Cardiac magnetic resonance imaging (MRI) is increasingly recognized as a promising tool for tissue characterization in atrial fibrillation (AF), providing detailed insights into anatomy, fibrosis, and scarring. While MRI cannot directly guide ablation lesions, its ability to identify arrhythmogenic substrates could improve patient stratification procedural planning. Despite these theoretical advantages, the clinical utility of guiding substrate-based strategies remains matter debate. Methods: Our review evaluates current evidence supporting integration workflow AF ablation. Specifically, we examine findings from randomized trials prospective studies that have investigated predictive value MRI-derived fibrosis quantification outcomes arrhythmia recurrence. We aim assess whether can enhance personalization predict treatment success. Challenges such variability protocols, lack standardization quantification, limited large-scale validation are also addressed. This provides comprehensive overview status potential evolving field

Language: Английский

Citations

0
Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID) DOI Creative Commons

Attila Kállai,

Anna Ungvari,

Dóra Csabán

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Targeting the SPP1/TGF-β1 axis in macrophages: A potential therapeutic mechanism for atrial fibrillation? DOI

Zhixing Fan,

Yifan Huang

International Journal of Cardiology, Journal Year: 2025, Volume and Issue: 433, P. 133312 - 133312

Published: April 23, 2025

Language: Английский

Citations

0
Salidroside treatment decreases the susceptibility of atrial fibrillation in diabetic mice by reducing mTOR-STAT3-MCP-1 signaling and atrial inflammation DOI

Wenpu Ren,

Yuting Huang,

Shan Meng

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113196 - 113196

Published: Sept. 21, 2024

Language: Английский

Citations

2
Recent advances in understanding the roles of T cells in atrial fibrillation DOI Creative Commons

Jiu Pu,

Yimei Du

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Sept. 30, 2024

Abstract Atrial fibrillation (AF) is a common arrhythmia associated with severe outcomes like heart failure and stroke. Recent studies highlight the crucial role of T in AF. Clinical have observed elevated levels CD4 + CD28 null cells, Th17/Treg CD8 related markers peripheral blood or atrial tissue AF patients, correlating disease severity cardiovascular events. These cell subsets contribute to through: (1) releasing inflammatory factors TNF-α IL-17 which affect calcium homeostasis electrical activity myocytes and/or promote fibrosis; (2) recruiting cells such as macrophages, causing local inflammation, oxidative stress, remodeling; (3) secreting cytotoxic proteins perforin granzymes, inducing apoptosis affecting their action potentials; (4) direct contact, influencing myocyte electrophysiology. Understanding these cell-mediated mechanisms may uncover new therapeutic targets for

Language: Английский

Citations

1
Oxygen‐Independent Photodynamic Therapy‐Mediated Selective Consumption of M1 Macrophage Against Ventricular Arrhythmias via Sympathetic Neuromodulation DOI Open Access
Heng Lin, Hengyang Liu,

Haosong Xi

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract The occurrence of myocardial infarction (MI)‐induced malignant ventricular arrhythmias (VAs) is closely associated with the hyperactivation left stellate ganglion (LSG). Proinflammatory M1 macrophage reported to aggravate sympathetic overactivation and cause VAs. Therefore, depletion anticipated inhibit LSG alleviate MI‐induced Herein, oxygen‐independent photodynamic therapy (Oi‐PDT) combined targeting applied selectively deplete in further treat Oi‐PDT, which overcomes limitation extremely dependence on oxygen content traditional PDT, constructed through generation oxidizing photogenerated holes (h + ) under irradiation near‐infrared (NIR) light prepared Oi‐PDT agent (PPSCD). Meanwhile, PPSCD targets conjunction SR‐A receptor. selective consumption attributed both apoptosis ferroptosis induced by h , 1 O 2 •− generated Oi‐PDT. In vivo tests indicated neural activity experienced a notable reduction from 104.5 ± 2.9 51.5 6.7 after MI treatment, thereby significantly inhibited implementation this study provides promising strategy for macrophages treatment VAs MI.

Language: Английский

Citations

0