NLRP3 inflammasome in cardiovascular diseases: an update

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Cardiovascular disease (CVD) continues to be the leading cause of mortality worldwide. The nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is involved in numerous types CVD. As part innate immunity, NLRP3 plays a vital role, requiring priming activation signals trigger inflammation. leads both release IL-1 family cytokines distinct form programmed cell death called pyroptosis. Inflammation related CVD has been extensively investigated relation inflammasome. In this review, we describe pathways triggering discuss its pathogenic effects on This study also provides an overview potential therapeutic approaches targeting

Language: Английский

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Environmental Metal Exposure and Cardiovascular Disease Risk

Journal of the American College of Cardiology, Journal Year: 2025, Volume and Issue: 85(10), P. e109 - e109

Published: March 1, 2025

Language: Английский

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Reply

Journal of the American College of Cardiology, Journal Year: 2025, Volume and Issue: 85(10), P. e111 - e111

Published: March 1, 2025

Language: Английский

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Urinary Metal Levels and Coronary Artery Calcification

Journal of the American College of Cardiology, Journal Year: 2025, Volume and Issue: 85(10), P. e107 - e107

Published: March 1, 2025

Language: Английский

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Metals and Cardiovascular Disease

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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