Probiotics: Protecting Our Health from the Gut DOI Creative Commons
Gael Urait Varela-Trinidad, Carolina Domínguez-Díaz, Karla Solórzano-Castanedo

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(7), P. 1428 - 1428

Published: July 14, 2022

The gut microbiota (GM) comprises billions of microorganisms in the human gastrointestinal tract. This microbial community exerts numerous physiological functions. Prominent among these functions is effect on host immunity through uptake nutrients that strengthen intestinal cells and involved immune response. GM are not limited to gut, but bidirectional interactions between various extraintestinal organs have been identified. These termed interorganic axes by several authors, which gut-brain, gut-skin, gut-lung, gut-heart, gut-metabolism stand out. It has shown an organism healthy or homeostasis when balance. However, altered dysbiosis represents a critical factor pathogenesis many local systemic diseases. Therefore, probiotics intervene this context, which, according published studies, allows balance be maintained GM, leading individual's good health.

Language: Английский

The gut microbiota in anxiety and depression – A systematic review DOI
Carra A. Simpson, Carmela Díaz‐Arteche, Djamila Eliby

et al.

Clinical Psychology Review, Journal Year: 2020, Volume and Issue: 83, P. 101943 - 101943

Published: Oct. 29, 2020

Language: Английский

Citations

657
Engineered living biomaterials DOI
Aleixandre Rodrigo‐Navarro, Shrikrishnan Sankaran, Matthew J. Dalby

et al.

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 1175 - 1190

Published: Aug. 31, 2021

Language: Английский

Citations

339
Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry DOI Creative Commons
Sabrina Mörkl, Mary I. Butler,

Anna Höll

et al.

Current Nutrition Reports, Journal Year: 2020, Volume and Issue: 9(3), P. 171 - 182

Published: May 13, 2020

Abstract Purpose of Review Probiotics are living bacteria, which when ingested in adequate amounts, confer health benefits. Gut microbes suggested to play a role many psychiatric disorders and could be potential therapeutic target. Between the gut brain, there is bi-directional communication pathway called microbiota-gut-brain axis. The purpose this review examine data from recent interventional studies focusing on probiotics gut-brain axis for treatment depression, anxiety schizophrenia. Recent Findings likely improve depression but not Regarding anxiety, only one trial showed an effect multispecies probiotic. However, determinants like duration treatment, dosage interactions have been thoroughly investigated deserve more scientific attention. Summary Microbiome-based therapies such as cautiously recommended enhance beneficial bacteria mood through

Language: Английский

Citations

253
The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health DOI Creative Commons
Francesca De Filippis, Edoardo Pasolli, Danilo Ercolini

et al.

FEMS Microbiology Reviews, Journal Year: 2020, Volume and Issue: 44(4), P. 454 - 489

Published: May 20, 2020

ABSTRACT Lactic acid bacteria (LAB) are present in foods, the environment and animal gut, although fermented foods (FFs) recognized as primary niche of LAB activity. Several strains have been studied for their health-promoting properties employed probiotics. FFs potential beneficial effects, which we review this article. They also an important source LAB, ingested daily upon FF consumption. In review, describe diversity occurrence food well gut microbiome. We discuss opportunities to study functional by considering availability both genomic metagenomic data public repositories, different latest computational tools analysis. addition, role probiotics reporting prevalence key features genomes surveying outcomes use clinical trials involving human subjects. Finally, highlight need further studies aimed at improving our knowledge link between LAB-fermented from perspective health promotion.

Language: Английский

Citations

213
The microbiota-immune axis as a central mediator of gut-brain communication DOI Creative Commons
Thomas C. Fung

Neurobiology of Disease, Journal Year: 2019, Volume and Issue: 136, P. 104714 - 104714

Published: Dec. 15, 2019

Intestinal inflammatory disorders are associated with neurophysiological and behavioral symptoms. Conversely, many of the central nervous system (CNS) accompanied by intestinal complications. These observations suggest that physiologies functionally linked. Indeed, a growing body literature has revealed multiple pathways mediating bidirectional communication between intestine CNS, collectively referred to as gut-brain axis. In particular, microbes naturally colonizing mammalian gastrointestinal (GI) tract, termed gut microbiota, not only correlate but also play causative role in regulating CNS function, development host behavior. Despite these findings, our understanding cellular molecular mechanisms mediate remains its infancy. However, members microbiota have been established potent modulators intestinal, systemic CNS-resident immune cell suggesting interactions may involve system. Multiple associations, including neuroinflammatory, neuropsychiatric neurodegenerative disorders, significant manifestations. this review, I discuss recent advances exploring microbiota-immune critical regulator axis context related disorders.

Language: Английский

Citations

175
Sources, formulations, advanced delivery and health benefits of probiotics DOI

Ume Roobab,

Zahra Batool, Muhammad Faisal Manzoor

et al.

Current Opinion in Food Science, Journal Year: 2020, Volume and Issue: 32, P. 17 - 28

Published: Jan. 18, 2020

Language: Английский

Citations

166
Ruminococcus gnavus: friend or foe for human health DOI Creative Commons

Emmanuelle H. Crost,

Erika Coletto, Andrew Bell

et al.

FEMS Microbiology Reviews, Journal Year: 2023, Volume and Issue: 47(2)

Published: March 1, 2023

Abstract Ruminococcus gnavus was first identified in 1974 as a strict anaerobe the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With advent metagenomics, R. associated both positively negatively with an increasing number intestinal extraintestinal diseases from inflammatory bowel neurological disorders. This prompted renewed interest understanding adaptation mechanisms gut, molecular mediators affecting association health disease. From ca. 250 publications citing since 1990, 94% were published last 10 years. In this review, we describe biological characterization gnavus, occurrence infant adult microbiota factors influencing colonization gastrointestinal tract; also discuss current state our knowledge on role host We highlight gaps hypothesis that differential outcomes are strain niche specific.

Language: Английский

Citations

152
The gut microbiota and mental health in adults DOI Creative Commons

Ellionore Järbrink‐Sehgal,

Anna Andréasson

Current Opinion in Neurobiology, Journal Year: 2020, Volume and Issue: 62, P. 102 - 114

Published: March 9, 2020

A growing body of evidence point toward the bidirectional gut microbiota-brain axis playing a role in mental health. Most this research is conducted on animals why we review summarize and comment upon recent studies evaluating microbiome health humans. Further support for relevance communication mood disorders has been presented, such as effect probiotics brain connectivity outcomes pregnancy related stress microbiota newborn child. However, heterogeneity between precludes conclusions regarding differences composition disease many are limited by cross-sectional design, small sample sizes multiple comparisons. Thus, well-designed longitudinal with larger size, accounting confounders needed.

Language: Английский

Citations

145
The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies DOI Open Access
Sauliha Alli,

Ilona Gorbovskaya,

Jonathan C.W. Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4494 - 4494

Published: April 19, 2022

An emerging body of literature demonstrates differences in the gut microbiome (GMB) patients with major depressive disorder (MDD) compared to healthy controls (HC), as well potential benefits prebiotic, probiotic, and synbiotic treatment. We conducted a systematic review 24 observational studies (n = 2817), 19 interventional trials 1119). assessed alpha diversity, beta taxa abundance changes MDD relative HC, effect prebiotics, probiotics, synbiotics on symptoms individuals clinical or subclinical depression. observed no significant diversity but difference between HC. There were fluctuations specific Probiotic synbiotic, not treatment showed modest benefit reducing over four nine weeks. The GMB profiles differ significantly from further are needed elucidate probiotic treatments antidepressants longer follow-up before these therapies implemented into practice.

Language: Английский

Citations

120
Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial DOI Creative Commons
Anna-Chiara Schaub, Else Schneider, Jorge F. Vázquez‐Castellanos

et al.

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: June 3, 2022

Abstract A promising new treatment approach for major depressive disorder (MDD) targets the microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions affected in MDD. This first randomized controlled trial determine whether short-term, high-dose probiotic supplementation reduces symptoms along with gut microbial neural changes depressed patients. Patients current episodes took either a multi-strain supplement or placebo over 31 days additionally treatment-as-usual. Assessments place before, immediately after again four weeks intervention. The Hamilton Depression Rating Sale (HAM-D) was assessed as primary outcome. Quantitative microbiome profiling neuroimaging used detect MGB axis. In sample that completed intervention (probiotics N = 21, 26), HAM-D scores decreased time interactions between group indicated stronger decrease probiotics relative group. Probiotics maintained diversity increased abundance of genus Lactobacillus , indicating effectivity increase specific taxa. associated Finally, putamen activation response neutral faces significantly Our data imply an add-on ameliorates microbiota brain, highlights role axis MDD emphasizes potential microbiota-related approaches accessible, pragmatic, non-stigmatizing therapies Trial Registration: www.clinicaltrials.gov identifier: NCT02957591.

Language: Английский

Citations

120