A Bio‐Inspired Perspective on Materials Sustainability DOI Creative Commons
Wolfgang Wagermaier, Khashayar Razghandi, Peter Fratzl

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

The article explores materials sustainability through a bio-inspired lens and discusses paradigms that can reshape the understanding of material synthesis, processing, usage. It addresses various technological fields, from structural engineering to healthcare, emphasizes natural cycles as blueprint for efficient recycling reuse. study shows functionality depends on both chemical composition modifications, which role processing. identifies strategies such mono-materiality multifunctionality, how responsivity, adaptivity, modularity, cellularity simplify assembly disassembly. Bioinspired reusing materials, defect tolerance, maintenance, remodeling, healing may extend product lifespans. principles circularity, longevity, parsimony are reconsidered in context "active materiality", dynamic paradigm. This concept expands traditional focus science structure-function relationships include development capable responding or adapting external stimuli. Concrete examples demonstrate being applied technology enhance materials. concludes by emphasizing interdisciplinary collaboration key factor developing sustainable resilient economy harmony with nature's cycles.

Language: Английский

Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives DOI Creative Commons
Han Liu, Qin Zhang, Sicheng Wang

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 14, P. 169 - 181

Published: Dec. 17, 2021

Nanosized extracellular vesicles derived from bacteria contain diverse cargo and transfer intercellular bioactive molecules to cells. Due their favorable interactions, cell membrane-derived bacterial (BEVs) have great potential become novel drug delivery platforms. In this review, we summarize the biogenesis mechanism compositions of various BEVs. addition, an overview effective isolation purification techniques BEVs is provided. particular, focus on application as nanocarriers for delivery. Finally, advances challenges after providing a comprehensive discussion in each section. We believe that deeper understanding will open new avenues exploitation applications.

Language: Английский

Citations

146

Engineered Living Hydrogels DOI
Xinyue Liu, María Eugenia Inda, Yong Lai

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(26)

Published: March 4, 2022

Living biological systems, ranging from single cells to whole organisms, can sense, process information, and actuate in response changing environmental conditions. Inspired by living engineered nonliving matrices are brought together, which gives rise the technology of materials. By designing functionalities structures matrices, materials be created detect variability surrounding environment adjust their functions accordingly, thereby enabling applications health monitoring, disease treatment, remediation. Hydrogels, a class soft, wet, biocompatible materials, have been widely used as for cells, leading nascent field hydrogels. Here, interactions between hydrogel described, focusing on how hydrogels influence cell behaviors affect properties. The environments, these enable versatile applications, also discussed. Finally, current challenges facing clinical settings highlighted.

Language: Английский

Citations

141

Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems DOI
Cong Xu, Qingfeng Ban, Wan Wang

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 349, P. 184 - 205

Published: July 8, 2022

Language: Английский

Citations

123

Engineered Living Materials For Sustainability DOI
Bolin An, Yan‐Yi Wang, Yuan‐Yuan Huang

et al.

Chemical Reviews, Journal Year: 2022, Volume and Issue: 123(5), P. 2349 - 2419

Published: Dec. 13, 2022

Recent advances in synthetic biology and materials science have given rise to a new form of materials, namely engineered living (ELMs), which are composed matter or cell communities embedded self-regenerating matrices their own artificial scaffolds. Like natural such as bone, wood, skin, ELMs, possess the functional capabilities organisms, can grow, self-organize, self-repair when needed. They also spontaneously perform programmed biological functions upon sensing external cues. Currently, ELMs show promise for green energy production, bioremediation, disease treatment, fabricating advanced smart materials. This review first introduces dynamic features systems potential developing novel We then summarize recent research progress on emerging design strategies from both perspectives. Finally, we discuss positive impacts promoting sustainability key future directions.

Language: Английский

Citations

120

Developing biomedical engineering technologies for reproductive medicine DOI Creative Commons
Yujuan Zhu, Bin Kong, Rui Liu

et al.

Smart Medicine, Journal Year: 2022, Volume and Issue: 1(1)

Published: Dec. 1, 2022

Infertility is a rising global health issue with far-reaching impact on the socioeconomic livelihoods. As there are highly complex causes of male and female infertility, it desired to promote maintain reproductive by integration advanced technologies. Biomedical engineering, mature technology applied in fields biology care, has emerged as powerful tool diagnosis treatment infertility. Nowadays, various promising biomedical engineering approaches under investigation address human can not only improve our fundamental understanding sperm follicle development bioengineered devices combined microfabrication, biomaterials, relevant cells, but also be repair uterine, ovary, cervicovaginal tissues restore tissue function. Here, we introduce infertility provide comprehensive summary technologies their applications medicine. Also, challenges prospects for clinical transformation discussed. We believe that this review will communications between engineers, biologists, clinicians potentially contribute these innovative research works immediate future.

Language: Английский

Citations

114

Engineered hydrogels for mechanobiology DOI
Ulrich Blache, Eden M. Ford, Byung Hang Ha

et al.

Nature Reviews Methods Primers, Journal Year: 2022, Volume and Issue: 2(1)

Published: Dec. 15, 2022

Language: Английский

Citations

113

A Review of 3D Polymeric Scaffolds for Bone Tissue Engineering: Principles, Fabrication Techniques, Immunomodulatory Roles, and Challenges DOI Creative Commons
Ahmed G. Abdelaziz, Hassan Nageh, Sara M. Abdo

et al.

Bioengineering, Journal Year: 2023, Volume and Issue: 10(2), P. 204 - 204

Published: Feb. 3, 2023

Over the last few years, biopolymers have attracted great interest in tissue engineering and regenerative medicine due to diversity of their chemical, mechanical, physical properties for fabrication 3D scaffolds. This review is devoted recent advances synthetic natural polymeric scaffolds bone (BTE) therapies. The comprehensively discusses implications biological macromolecules, structure, composition used BTE. Various approaches fabricating BTE are discussed, including solvent casting particle leaching, freeze-drying, thermally induced phase separation, gas foaming, electrospinning, sol–gel techniques. Rapid prototyping technologies such as stereolithography, fused deposition modeling, selective laser sintering, bioprinting also covered. immunomodulatory roles utilized applications discussed. In addition, features challenges polymer fabricated using advanced additive manufacturing (rapid prototyping) addressed compared conventional subtractive Finally, applying scaffold-based treatments practice discussed in-depth.

Language: Английский

Citations

83

3D printing of bio-instructive materials: Toward directing the cell DOI Creative Commons
Piotr Stanisław Zieliński, Pavan Kumar Reddy Gudeti,

Timo Rikmanspoel

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 19, P. 292 - 327

Published: April 23, 2022

Fabrication of functional scaffolds for tissue engineering and regenerative medicine applications requires material systems with precise control over cellular performance. 3D printing is a powerful technique to create highly complex multicomponent structures well-defined architecture composition. In this review paper, we explore extrusion-based methods (EBP, i.e., Near Field Electrospinning (NFES), Melt Electrowriting (MEW), Fused Deposition Modeling (FDM), extrusion bioprinting) in terms their ability produce bio-instructive properties. These provide spatio-temporal guidance cells, allowing controlled regeneration maturation. Multiple physical biochemical cues introduced the EBP are evaluated direct cell alignment, proliferation, differentiation, specific ECM production, We indicate that have different impacts depending on system, type used, or coexistence multiple cues. Therefore, they must be carefully chosen based targeted application. propose future directions materials development, including such concepts as metamaterials, hybrid living materials, 4D printing. The gathers knowledge essential designing new response, fabrication advanced engineered tissue, developing better understanding biology, especially response biomaterial.

Language: Английский

Citations

80

Synthetic protein condensates for cellular and metabolic engineering DOI
Zhi‐Gang Qian,

Sheng-Chen Alex Huang,

Xiao‐Xia Xia

et al.

Nature Chemical Biology, Journal Year: 2022, Volume and Issue: 18(12), P. 1330 - 1340

Published: Nov. 18, 2022

Language: Английский

Citations

78

Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment DOI
Haisheng Li, Buying Li,

Dalun Lv

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 196, P. 114778 - 114778

Published: March 16, 2023

Language: Английский

Citations

72