Potential role of insulin on the pathogenesis of depression DOI Creative Commons

Xiao Han Zou,

Li Sun, Wei Yang

et al.

Cell Proliferation, Journal Year: 2020, Volume and Issue: 53(5)

Published: April 13, 2020

Abstract The regulation of insulin on depression and depression‐like behaviour has been widely reported. Insulin activation its receptor can promote learning memory, affect the hypothalamic‐pituitary‐adrenal axis (HPA) balance, regulate secretion neurotrophic factors neurotransmitters, interact with gastrointestinal microbiome, exert neuroprotective effects have an impact depression. However, role remains largely unclear. Therefore, in this review, we summarized potential It may provide new insight for clarifying pathogenesis

Language: Английский

Common mental disorders in irritable bowel syndrome: pathophysiology, management, and considerations for future randomised controlled trials DOI
Heidi M. Staudacher, Antonina Mikocka‐Walus, Alexander C. Ford

et al.

˜The œLancet. Gastroenterology & hepatology, Journal Year: 2021, Volume and Issue: 6(5), P. 401 - 410

Published: Feb. 15, 2021

Language: Английский

Citations

64
The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors DOI Creative Commons
Hao Lin, Qingqing Guo, Zhiyong Wen

et al.

Microbial Cell Factories, Journal Year: 2021, Volume and Issue: 20(1)

Published: Dec. 28, 2021

Anxiety and depression are complications in Irritable bowel syndrome (IBS) patients. In this study, we recruited 18 IBS patients with mild-modest anxiety behaviors, after the screening, defined FMT treatment group (n = 9) control 9). The symptom severity scale (IBS-SSS), Hamilton Rating Scale (HAM-A), Depression (HAM-D), Bowel Syndrome Quality of Life (IBS-QOL) Bristol stool (BSS) were evaluated one week before (baseline), one-week-, one-month-, two-month-, three-month-following FMT. Meanwhile, determined SCFAs patient's feces serum continued metagenomic analysis microorganisms feces.The results showed that behavior gradually improved treatment. Moreover, illness quality life had also been relieved significantly. content isovaleric acid valeric was significantly reduced compared to Col group. Metagenomic decreased abundance Faecalibacterium, Eubacterium Escherichia. From KEGG functional analysis, confirmed top five abundant pathways "bacterial chemotaxis, "flagellar assembly", "glycine, serine threonine metabolism", "apoptosis", invasion epithelial cells".FMT can effectively alleviate behaviors IBS-D reduce IBS-SSS score, indicating improve patients' symptoms. high throughput sequencing show Bifidobacterium Escherichia play most critical role formation recovery GC/MS data indicated faeces might be more suitable as a metabolic indicator remission. Trial registration ChiCTR, ChiCTR1900024924, Registered 3 August 2019, https://www.chictr.org.cn/showproj.aspx?proj=41676 .

Language: Английский

Citations

59
Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome DOI Open Access
Yoshiyuki Mishima, Shunji Ishihara

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10235 - 10235

Published: Sept. 23, 2021

Irritable bowel syndrome (IBS) is a chronic functional disorder that affects the gastrointestinal tract. Details regarding pathogenesis of IBS remain largely unknown, though dysfunction brain-gut-microbiome (BGM) axis major etiological factor, in which neurotransmitters serve as key communication tool between enteric microbiota and brain. One most important pathology serotonin (5-HT), it influences motility, pain sensation, mucosal inflammation, immune responses, brain activity, all shape features. Genome-wide association studies discovered susceptible genes for serotonergic signaling pathways. In clinical practice, treatment strategies targeting 5-HT were effective certain portion cases. The synthesis intestinal enterochromaffin cells host regulated by resident microbiota. Dysbiosis can trigger development, potentially through aberrant BGM axis; thus, manipulation gut may be an alternative strategy. However, precise information mechanisms underlying microbiota-mediated pathway related to remains unclear. present review summarizes current knowledge recent progress understanding microbiome-serotonin interaction

Language: Английский

Citations

57
Effects of a Low-FODMAP Diet on Irritable Bowel Syndrome in Both Children and Adults—A Narrative Review DOI Open Access
Ionela Daniela Morariu,

Liliana Avasilcăi,

Mădălina Vieriu

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2295 - 2295

Published: May 13, 2023

Irritable bowel syndrome is a typical gastrointestinal disease that causes bloating, flatulence, abdominal pain, diarrhoea, constipation, or alteration of the last two in adults and children. A diet low fermentable oligosaccharides, disaccharides, monosaccharides, polyols (FODMAP) one potential treatment strategies to reduce symptoms increase quality life. The present narrative review aims general overview current studies have evaluated efficacy low-FODMAP against other diets symptoms, nutrient intake children, lifestyle quality. research was performed using seven searchable databases, which included Cochrane Central Register Controlled Trials (CENTRAL), Database Systematic Reviews (CDSR), Excerpta Medica (EMBASE), Medline, PubMed, Scopus, Web Science, up March 2023. In conclusion, there significant evidence follow-up might be feasible first-line therapeutic strategy stomach discomfort, life for patients with irritable syndrome.

Language: Английский

Citations

37
The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles DOI Creative Commons
Stefanie Malan‐Müller, Mireia Valles‐Colomer, Tomás Palomo

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: Jan. 18, 2023

The prevalence of anxiety and depression soared following the COVID-19 pandemic. To effectively treat these conditions, a comprehensive understanding all etiological factors is needed. This study investigated fecal microbial features associated with mental health outcomes (symptoms anxiety, depression, or posttraumatic stress disorder (PTSD)) in Spanish cohort aftermath Microbial communities from stool samples were profiled 198 individuals who completed validated, self-report questionnaires. 16S ribosomal RNA gene V3-4 amplicon sequencing was performed. diversity community structure analyzed, together relative taxonomic abundance. In our N=198, 17.17% reported depressive symptoms, 37.37% state 40.90% trait 8.08% PTSD high levels comorbidity. Individuals had lower Simpson's diversity. Fusicatenibacter saccharivorans reduced comorbid + whilst an expansion Proteobacteria depletion Synergistetes phyla noted symptoms. abundance Anaerostipes positively correlated childhood trauma, higher Turicibacter sanguinis Lentisphaerae found experienced life-threatening traumas. infection vaccination influenced overall composition distinct profiles. These findings will help lay foundation for future studies to identify role players symptoms provide therapeutic targets improve outcomes.

Language: Английский

Citations

34
Assessing the relationship between gut microbiota and irritable bowel syndrome: a two-sample Mendelian randomization analysis DOI Creative Commons
Bin Liu, Ding Ye, Hong Yang

et al.

BMC Gastroenterology, Journal Year: 2023, Volume and Issue: 23(1)

Published: May 12, 2023

Abstract Background Growing evidence has suggested that gut microbiota is closely related to the risk of irritable bowel syndrome (IBS), but whether there a causal effect remains unknown. We adopted Mendelian randomization (MR) approach evaluate potential relationships between and IBS. Methods Genetic instrumental variables for were identified from genome-wide association study (GWAS) 18,340 participants. Summary statistics IBS drawn GWAS including 53,400 cases 433,201 controls. used inverse-variance weighted (IVW) method as primary analysis. To test robustness our results, we further performed weighted-median method, MR-Egger regression, MR pleiotropy residual sum outlier test. Finally, reverse analysis was possibility causation. Results suggestive associations three bacterial traits (odds ratio (OR): 1.08; 95% confidence interval (CI): 1.02, 1.15; p = 0.011 phylum Actinobacteria; OR: 0.95; CI: 0.91, 1.00; 0.030 genus Eisenbergiella 1.10; 1.03, 1.18; 0.005 Flavonifractor ). The results sensitivity analyses these consistent. did not find statistically significant in Conclusions Our systematic provide support relationship several taxa More studies are required show how affects development

Language: Английский

Citations

32
Probiotics for the treatment of depression and its comorbidities: A systemic review DOI Creative Commons
Jie Gao, Na Zhao, Yiwen Cheng

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: April 17, 2023

Depression is one of the most common psychiatric conditions, characterized by significant and persistent depressed mood diminished interest, often coexists with various comorbidities. The underlying mechanism depression remain elusive, evidenced lack an appreciate therapy. Recent abundant clinical trials animal studies support new notion that gut microbiota has emerged as a novel actor in pathophysiology depression, which partakes bidirectional communication between brain through neuroendocrine, nervous, immune signaling pathways, collectively known microbiota-gut-brain (MGB) axis. Alterations can trigger changes neurotransmitters, neuroinflammation, behaviors. With transition human microbiome research from studying associations to investigating mechanistic causality, MGB axis therapeutic target its These insights have fueled idea targeting on may open windows for efficient treatment Probiotics, live beneficial microorganisms, be used modulate dysbiosis into eubiosis modify occurrence development In present review, we summarize recent findings regarding discuss potential effects probiotics

Language: Английский

Citations

30
Fibromyalgia and Irritable Bowel Syndrome Interaction: A Possible Role for Gut Microbiota and Gut-Brain Axis DOI Creative Commons
Cinzia Garofalo, Costanza Maria Cristiani, Sara Ilari

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1701 - 1701

Published: June 13, 2023

Fibromyalgia (FM) is a serious chronic pain syndrome, characterised by muscle and joint stiffness, insomnia, fatigue, mood disorders, cognitive dysfunction, anxiety, depression intestinal irritability. Irritable Bowel Syndrome (IBS) shares many of these symptoms, FM IBS frequently co-exist, which suggests common aetiology for the two diseases. The exact physiopathological mechanisms underlying both onset are unknown. Researchers have investigated possible causes, including alterations in gut microbiota, contain billions microorganisms human digestive tract. gut-brain axis has been proven to be link between microbiota central nervous system, can then control composition. In this review, we will discuss similarities IBS. Particularly, focus our attention on symptomatology overlap as well composition patients. We also briefly potential therapeutic approaches based manipulations that successfully used could employed patients relieve pain, ameliorate rehabilitation outcome, psychological distress symptoms.

Language: Английский

Citations

26
Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice DOI
Ying-Dan Zhang, Dongdong Shi,

Bing-Bing Liao

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(6), P. 1782 - 1797

Published: Jan. 25, 2024

Language: Английский

Citations

10
Co-decoction of Lilii bulbus and Radix Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflammation and intestinal permeability associated with chronic stress-induced depression via the gut microbiota-brain axis DOI

Qiancheng Mao,

Hongxiu Zhang,

Zhe Zhang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155510 - 155510

Published: March 11, 2024

Language: Английский

Citations

10