Childhood Maltreatment and Amygdala-Mediated Anxiety and Posttraumatic Stress Following Adult Trauma

Biological Psychiatry Global Open Science, Journal Year: 2024, Volume and Issue: 4(4), P. 100312 - 100312

Published: April 5, 2024

Childhood abuse (physical, emotional, and sexual) is associated with aberrant connectivity of the amygdala, a key threat processing region. Heightened amygdala activity also predicts adult anxiety posttraumatic stress disorder (PTSD) symptoms, as do experiences childhood abuse. The current study explored whether resting-state functional (rsFC) may explain relationship between PTSD symptoms following trauma exposure in adults. Two-weeks post-trauma, survivors (N=152, M age=32.61; SD=10.35; female=57.2%) completed Trauma Questionnaire underwent magnetic resonance imaging. were assessed six-months post-trauma. Seed-to-voxel analyses evaluated association rsFC. A mediation model potential mediating role on post-traumaanxiety PTSD. was increased precuneus, covarying for age, gender, neglect, baseline symptoms. Amygdala-precuneus rsFC significant mediator effect six months post-trauma (B=0.065, CI [0.013, 0.130], SE=0.030), but not secondary analysis investigating depression an outcome significant. be underlying neural mechanism by which increases risk trauma. Specifically, this heightened reflect attentional vigilance or tendency toward negative self-referential thoughts. Findings suggest that contribute to longstanding upregulation circuits, makes one vulnerable anxiety-related adulthood.

Language: Английский

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Depressed patients with childhood maltreatment display altered intra- and inter-network resting state functional connectivity

NeuroImage Clinical, Journal Year: 2024, Volume and Issue: 43, P. 103632 - 103632

Published: Jan. 1, 2024

Childhood maltreatment (CM) is a major risk factor for the development of depressive disorder (MDD). To gain more knowledge on how adverse childhood experiences influence brain architecture, we studied functional connectivity (FC) alterations neural networks depressed patients with, or without history CM. Depressed with severe (n = 18), MDD 19), and matched healthy controls 20) were examined resting state MRI. History was assessed 28-item Trauma Questionnaire. Intra- inter-network FC evaluated using FMRIB Software Library CONN toolbox. We found numerous intra- between maltreated non-maltreated patients. Intra-network differences in default mode, visual auditory networks, cerebellum. Network modelling revealed several connecting mode network executive control, salience cerebellar networks. Increased sensory-motor visual, cerebellar, Relatively small sample size, cross-sectional design, retrospective self-report questionnaire to assess experiences. Our findings confirm that severely display strengths, not only their fronto-limbic circuits, but also sensory-motor, auditory, These may explain individuals typically altered perception are prone develop neurological symptom (conversion disorder) adulthood.

Language: Английский

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Childhood psychological maltreatment subtypes and depression among Chinese college students: the role of self-compassion and perceived negative attention bias

BMC Psychology, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 2, 2025

Research on childhood psychological maltreatment lags behind that other forms of maltreatment. While it has been identified as a significant predictor depression, the specific underlying mechanisms linking its subtypes (emotional abuse and emotional neglect) to depression remain unclear. This study aimed examine association between from both factors (self-compassion) cognitive (perceived negative attention bias), well gender differences. Using questionnaire survey, total 587 college students completed self-report questionnaires, including subtypes, self-compassion, perceived bias, depression. used structural equation models serial mediating role differences by Amos 24.0. Childhood positively predicted Self-compassion played Perceived bias but not significantly neglect (including subtypes) There were no in role. distinct roles maltreatment, A self-compassion was observed associations overall abuse, In contrast, case neglect, only served mediator. These findings enlighten us interventions enhancing reducing may help mitigate exposed particularly abuse. Conversely, focused increasing be more effective those neglect.

Language: Английский

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Altered neurovascular coupling in depression with childhood maltreatment

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111348 - 111348

Published: April 1, 2025

Language: Английский

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Arousal modulates the amygdala-insula reciprocal connectivity during naturalistic emotional movie watching

NeuroImage, Journal Year: 2023, Volume and Issue: 279, P. 120316 - 120316

Published: Aug. 9, 2023

Emotional arousal is a complex state recruiting distributed cortical and subcortical structures, in which the amygdala insula play an important role. Although previous neuroimaging studies have showed that manifest reciprocal connectivity, effective connectivities modulatory patterns on amygdala-insula interactions underpinning are still largely unknown. One of reasons may be attributed to static discrete laboratory brain imaging paradigms used most existing studies. In this study, by integrating naturalistic-paradigm (i.e., movie watching) functional magnetic resonance (fMRI) with computational affective model predicts dynamic for stimuli, we investigated effect input connections. Specifically, predicted served as regressors general linear (GLM) analysis activations were identified accordingly. The regions interest bilateral insula) localized according GLM activation map. connectivity then inferred using causal modeling (DCM). Our experimental results demonstrated was site driving had connections between insula. study provides novel evidence underlying neural mechanisms dynamical naturalistic setting.

Language: Английский

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Aberrant static and dynamic functional connectivity of amygdala subregions in patients with major depressive disorder and childhood maltreatment

NeuroImage Clinical, Journal Year: 2022, Volume and Issue: 36, P. 103270 - 103270

Published: Jan. 1, 2022

Major depressive disorder (MDD) with childhood maltreatment is a heterogeneous clinical phenotype of depression prominent features brain disconnectivity in areas linked to maltreatment-related emotion processing (e.g., the amygdala). However, static and dynamic alterations functional connectivity amygdala subregions have not been investigated MDD maltreatment. Here, we explored whether (i.e., medial [MeA] lateral [LA]) exhibited (sFC) (dFC) disruption, these disruptions were related We compared sFC dFC patterns (n = 48), without 30), healthy controls 57), 46). The bilateral MeA LA selected as seeds FC analysis. results revealed disruption pattern maltreated patients, characterized by abnormalities involving MeA, LA, theory mind-related including middle occipital area, frontal gyrus, superior angular supplementary motor areas, temporal cingulate calcarine gyrus. Significant correlations detected between impaired Furthermore, served moderator relationship sexual abuse severity. Our findings neurobiological maltreatment, providing new evidence regarding vulnerability psychiatric disorders.

Language: Английский

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Unraveling the link between childhood maltreatment and depression: Insights from the role of ventral striatum and middle cingulate cortex in hedonic experience and emotion regulation

Development and Psychopathology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Jan. 5, 2024

Abstract Childhood maltreatment is an established risk factor for psychopathology. However, it remains unclear how childhood traumatic events relate to mental health problems and the brain involved. This study examined serial mediation effect of morphological alterations emotion-/reward-related functions on linking relationship from depression. We recruited 156 healthy adolescents young adults additional sample 31 with major depressive disorder assessment maltreatment, symptoms, cognitive reappraisal anticipatory/consummatory pleasure. Structural MRI data were acquired identify maltreatment-related cortical subcortical differences. The models suggested that emotional abuse neglect, was respectively associated increased gray matter volume in ventral striatum greater thickness middle cingulate cortex. These structural further related reduced anticipatory pleasure disrupted reappraisal, which contributed more severe symptoms among individuals. above mediating effects not replicated our clinical group partly due small size. Preventative interventions can target reward systems foster resilience reduce likelihood future psychiatric disorders individuals a history maltreatment.

Language: Английский

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Functional connectivity of the amygdala subregions and the antidepressant effects of repeated ketamine infusions in major depressive disorder

European Psychiatry, Journal Year: 2024, Volume and Issue: 67(1)

Published: Jan. 1, 2024

Abstract Background Amygdala subregion-based network dysfunction has been determined to be centrally implicated in major depressive disorder (MDD). Little is known about whether ketamine modulates amygdala subarea-related networks. We aimed investigate the relationships between changes resting-state functional connectivity (RSFC) of subregions and treatment identify important neuroimaging predictors outcomes. Methods Thirty-nine MDD patients received six doses (0.5 mg/kg). Depressive symptoms were assessed, magnetic resonance imaging (MRI) scans performed before after treatment. Forty-five healthy controls underwent one MRI scan. Seed-to-voxel RSFC analyses on subregions, including centromedial (CMA), laterobasal (LBA), superficial subregions. Results Abnormal left LBA precuneus related therapeutic efficacy ketamine. There significant differences bilateral CMA with orbital part superior frontal gyrus right middle responders nonresponders following Moreover, there was a difference temporal gyrus/middle (STG/MTG) at baseline, which could predict antidepressant effect Day 13. Conclusions The mechanism by improves may its regulation subregion. STG/MTG response

Language: Английский

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Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms

The International Journal of Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 25(10), P. 807 - 817

Published: June 20, 2022

The hypothalamic neuropeptide oxytocin (OXT) may exert anxiolytic and stress-reducing actions via modulatory effects on amygdala circuits. Animal models initial findings in humans suggest that some of these are mediated by interactions with other neurotransmitter systems, particular the serotonin (5-HT) system. Against this background, present pharmacological resting-state functional magnetic resonance imaging study aimed to determine whether OXT stress-associated intrinsic networks 5-HT.We employed a randomized, placebo-controlled, double-blind parallel-group, experiment 4 treatment groups n = 112 healthy male participants. Participants underwent transient decrease 5-HT signaling acute tryptophan depletion (ATD) or corresponding placebo-control protocol before administration intranasal (24 IU) placebo spray.OXT modulation exerted interactive coupling left ipsilateral hippocampus adjacent midbrain. increased pathway, whereas effect was significantly attenuated during transiently decreased central serotonergic induced depletion. In absence modulation, pathway showed trend for an association self-reported stress perception everyday life. No were observed right amygdala.Together, provide first evidence, our knowledge, amygdala-hippocampal-midbrain pathways critically system humans.

Language: Английский

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Brain alterations in adolescents with first-episode depression who have experienced adverse events: evidence from resting-state functional magnetic resonance imaging

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: April 9, 2024

Introduction Adverse life events constitute primary risk factors for major depressive disorder (MDD), influencing brain function and structure. Adolescents, with their brains undergoing continuous development, are particularly susceptible to enduring impacts of adverse events. Methods We investigated differences correlations among childhood trauma, negative events, alterations in adolescents first-episode MDD. The study included 23 patients MDD 19 healthy controls, aged 10–19 years. All participants underwent resting-state functional magnetic resonance imaging were assessed using the beck depression inventory, trauma questionnaire, adolescent self-rating checklist. Results Compared more likely have experienced emotional abuse, physical neglect, interpersonal relationship problems, learning stress (all p’ < 0.05). These significantly correlated functions p Discussion This contributes novel evidence on underlying process between function, depression, emphasizing significant neurophysiological impact environmental factors.

Language: Английский

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