Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions

World Psychiatry, Journal Year: 2023, Volume and Issue: 22(3), P. 394 - 412

Published: Sept. 15, 2023

Treatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD demonstrated predictive utility in terms clinical decision-making outcomes does not currently exist. Instead, a plethora definitions have been proposed, which vary significantly their conceptual framework. The absence hampers precise estimates the prevalence TRD, also belies efforts to identify risk factors, prevention opportunities, effective interventions. In addition, it results heterogeneity practice decision-making, adversely affecting quality care. US Food Drug Administration (FDA) European Medicines Agency (EMA) adopted most used (i.e., inadequate response minimum two antidepressants despite adequacy treatment trial adherence treatment). It estimated that at least 30% persons meet this definition. significant percentage are actually pseudo-resistant (e.g., due inadequacy trials or non-adherence Although sociodemographic, clinical, contextual factors known negatively moderate depression, very few regarded as non-response across modalities treatment. Intravenous ketamine intranasal esketamine (co-administered an antidepressant) established efficacious management TRD. Some second-generation antipsychotics aripiprazole, brexpiprazole, cariprazine, quetiapine XR) proven adjunctive treatments partial responders, but only olanzapine-fluoxetine combination has studied FDA-defined Repetitive transcranial magnetic stimulation (TMS) FDA-approved for individuals accelerated theta-burst TMS recently showing efficacy. Electroconvulsive therapy acute maintenance intervention preliminary evidence suggesting non-inferiority intravenous ketamine. Evidence extending antidepressant trial, medication switching combining mixed. Manual-based psychotherapies on own offer symptomatic relief when added conventional antidepressants. Digital therapeutics under study represent potential future vista population.

Language: Английский

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Mediterranean diet in the management and prevention of obesity

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 174, P. 112121 - 112121

Published: Feb. 17, 2023

The current pandemic of obesity represents a major global public health problem, mainly due to its association with chronic non-communicable disabling conditions and increased mortality. Population aging increases the chances diseases allowing longer exposure risk factors for these conditions. Obesity is factor contributing pathological aging. Numerous epidemiological studies have shown that death cardiovascular disease cancer progressively as overweight rise. Nutrition research now focused on effects combinations foods in dietary patterns instead those single nutrients or foods. model largest body evidence benefit traditionally followed by inhabitants some Mediterranean countries. There confirming inverse adhering diet obesity. Four meta-analyses randomized controlled trials, including up 16 greater reduction weight BMI MedDiet compared other diets, while meta-analysis 7 prospective cohort studies, found reduced becoming obese gaining over time associated higher adherence MedDiet. This narrative review examines reporting associations overweight/obesity age-associated related

Language: Английский

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Synthesis, Antibacterial Activities and Theoretical Study of Polyhydroquinoline Derivatives

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(41)

Published: Nov. 2, 2023

Abstract In the present study, novel bis ‐Schiff base derivatives of polyhydroquinoline were synthesized through Hantzsch condensation reaction in excellent yields. Initially, a mixture dimedone, ethyl acetoacetate, ammonium acetate and esterified aldehydes refluxed ethanol for 7–9 hrs. Then, hydrazine hydrate was treated with obtained to form ‐hydrazide corresponding polyhydroquinoline. Finally, independently substituted aromatic get desired The new confirmed by modern spectroscopic techniques such as 1 H‐NMR, 13 C‐NMR HR‐ESI‐MS. targeted compounds evaluated their antibacterial activity using disc diffusion method. derivative four OH‐group found more effective against Bacillus megaterium, subtilis IM, ATCC, Salmonella enterica Proteus vulgaris FMC II zone inhibition 8.3, 7.6, 7.3, 6.6 6.3 mm, respectively. DFT study performed on both materials studio Gaussian 09 package, which showed good agreement experimental data. NLO calculated consider candidates NLO. global reactivity, NBO H‐NMR correlation also studied, agreement. cheap reagents, short time yields are some features current work.

Language: Английский

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Exploring the Bidirectional Relationship Between Depression and Obesity

Endocrinology and Metabolism Clinics of North America, Journal Year: 2025, Volume and Issue: 54(1), P. 193 - 206

Published: Feb. 5, 2025

Language: Английский

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The Co-occurrence of Depression and Obesity

The Journal of Clinical Psychiatry, Journal Year: 2024, Volume and Issue: 85(2)

Published: June 3, 2024

Language: Английский

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The Nonlinear Relationship Between Body Mass Index (BMI) and Perceived Depression in the Chinese Population

Psychology Research and Behavior Management, Journal Year: 2023, Volume and Issue: Volume 16, P. 2103 - 2124

Published: June 1, 2023

Existing studies on the association between BMI and depression report conflicting results with some demonstrating a positive relationship, while others negative link or insignificant correlation. Very limited research nonlinear relationship has yet to clarify reliability robustness of potential nonlinearity whether more complex exists. This paper aims systematically investigate two factors applying rigorous statistical methods, as well explore heterogeneity their association.A large-scale nationally representative dataset, Chinese General Social Survey, is used empirically analyze perceived depression. Various tests are employed check nonlinearity.Results indicate that there U-shaped depression, turning point (25.718) very close slightly larger than upper limit range healthy weight (18.500 ≤ < 25.000) defined by World Health Organization. Both high low BMIs associated increased risk for depressive disorders. Furthermore, higher at almost all levels among individuals who older, female, lower educated, unmarried, in rural areas, belonging ethnic minorities, non-Communist Party China members, those income uncovered social security. In addition, these subgroups have smaller inflection points self-rated sensitive BMI.This confirms significant trend Therefore, it important account variations this across different categories when using predict risk. Besides, study clarifies management goals achieving an appropriate from mental health perspective identifies vulnerable

Language: Английский

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Factors associated with hopelessness, depression and anxiety in the Honduran-Central America population during the COVID-19 pandemic

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: March 1, 2023

The mental health of the population has been affected by COVID-19, reporting in many populations higher levels depressive, anxious and stress symptoms, however, Honduras there are no studies showing impact COVID-19 on population.To determine factors associated with hopelessness, depression anxiety times Honduran population.Cross-sectional analytical study. Three scales were used, Beck for Hamilton anxiety, through interviews attending different care throughout country. Descriptive statistics obtained. For Hopelessness Scale was used; used.Of 8,125 participants, general showed results hopelessness 14.9%, 12.9% 1.2%, less among women (p = 0.004), university students < 0.001), but greater those who had a family member deceased diabetes mellitus (DM) history illness 0.001) or consumed drugs last 6 months 0.001). There more arterial hypertension 0.002), obesity 0.019), DM infected 0.023), according to having 0.045) 0.001).The presented important differences socio-pathological, loss members previous illnesses, this presentation problems sphere.We found we population.

Language: Английский

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Antidepressants and Weight Gain: An Update on the Evidence and Clinical Implications

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 3, 2025

Language: Английский

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The role of dietary interventions in the prevention of noncommunicable diseases

Vrach, Journal Year: 2025, Volume and Issue: unknown, P. 16 - 20

Published: Feb. 23, 2025

This article presents a brief review of the scientific literature examining role and importance dietary interventions recommended for prevention noncommunicable diseases. The features Mediterranean diet, DASH diet some others are described. Data on their effect blood pressure, glucose, body mass index presented. main obstacles to widespread use these noted, which include cultural characteristics consumers, higher cost proposed diets, need spend more time food preparation, control size portions eaten.

Language: Английский

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Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Introduction Increasing evidence suggests that individuals with obesity are at a higher risk of developing depression, and conversely, depression can contribute to the onset obesity, creating detrimental cycle. This study aims investigate potential shared biological pathways between by examining genetic correlations, identifying common polymorphisms, conducting cross-trait analyses. Methods We assessed correlation using linkage disequilibrium score regression high-density lipoprotein levels. combined two different sources data METAL employed bidirectional Mendelian randomization determine causal relationship depression. Additionally, we conducted multivariate trait analysis MTAG method improve statistical robustness identify novel associations. Furthermore, performed thorough investigation independent loci GCTA-COJO, PLACO, MAGMA, POPS, SMR, integrating QTL information methods further genes proteins. Results Our revealed correlations positive relationships highlighting SNP (rs10789340). identified RPL31P12, NEGR1, DCC as for Using BLISS method, SCG3 FLRT2 drug targets. Limitation Most our from Europe, which may limit generalization findings other ethnic populations. Conclusion demonstrates SNPs, genes, proteins, These deeper understanding their pathogenesis identification therapeutic

Language: Английский

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