American Journal of Reproductive Immunology,
Journal Year:
2024,
Volume and Issue:
91(2)
Published: Feb. 1, 2024
Abstract
Problem
Currently,
there
is
a
variety
of
evidence
linking
the
gut
microbiota
to
changes
in
sex
hormones.
In
contrast,
causal
relationship
between
SHBG,
carrier
hormones,
and
unclear.
Method
Study
Bidirectional
two‐sample
Mendelian
randomization
(MR)
analysis
was
used
detect
effect
SHBG
microbiome.
Summary
statistics
genome‐wide
association
studies
(GWASs)
for
microbiome
were
obtained
from
public
datasets.
Inverse‐variance
weighting
(IVW),
weighted
median,
mode,
MR‐Egger
simple
mode
methods
operate
MR
analysis.
F
‐statistics
sensitivity
analyses
performed
evaluate
bias
reliability.
Results
When
we
set
as
exposure
outcome,
identified
nine
relationships.
males,
Coprobacter
(PIVW
=
2.01
×
10
−6
),
Ruminococcus
2
3.40
−5
Barnesiella
2.79
−2
Actinobacteria
3.25
)
Eubacterium
fissicatena
groups
3.64
associated
with
lower
levels;
Alphaproteobacteria
1.61
higher
levels.
females,
Lachnoclostridium
9.75
−3
Defluviitaleaceae
UCG011
3.67
Victivallaceae
2.23
According
results
reverse
analysis,
three
significant
found
on
microbiota.
Dorea
4.17
Clostridiales
4.36
7.44
−4
higherr
No
signifcant
heterogeneity
instrumental
variables
or
horizontal
pleiotropy
bidirectional
Conclusions
This
study
may
provide
new
insights
into
hormone‐binding
protein
levels,
well
treatment
prevention
strategies
diseases
such
abnormal
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 17, 2024
Background
The
associations
between
gut
microbiota
and
cardiovascular
disease
have
been
reported
in
previous
studies.
However,
the
relationship
endocarditis
remains
unclear.
Methods
A
bidirectional
Mendelian
randomization
(MR)
study
was
performed
to
detect
association
endocarditis.
Inverse
variance
weighted
(IVW)
method
considered
main
result.
Simultaneously,
heterogeneity
pleiotropy
tests
were
conducted.
Results
Our
suggests
that
family
Victivallaceae
(
p
=
0.020),
genus
Eubacterium
fissicatena
group
0.047),
Escherichia
Shigella
0.024),
Peptococcus
0.028)
Sellimonas
0.005)
play
protective
roles
Two
microbial
taxa,
including
Blautia
0.006)
Ruminococcus2
0.024)
increase
risk
of
At
same
time,
has
a
negative
effect
on
0.048).
Besides,
no
or
found
this
study.
Conclusion
emphasized
certain
role
specific
patients
with
clarified
microbiota.
American Journal of Reproductive Immunology,
Journal Year:
2024,
Volume and Issue:
91(2)
Published: Feb. 1, 2024
Abstract
Problem
Currently,
there
is
a
variety
of
evidence
linking
the
gut
microbiota
to
changes
in
sex
hormones.
In
contrast,
causal
relationship
between
SHBG,
carrier
hormones,
and
unclear.
Method
Study
Bidirectional
two‐sample
Mendelian
randomization
(MR)
analysis
was
used
detect
effect
SHBG
microbiome.
Summary
statistics
genome‐wide
association
studies
(GWASs)
for
microbiome
were
obtained
from
public
datasets.
Inverse‐variance
weighting
(IVW),
weighted
median,
mode,
MR‐Egger
simple
mode
methods
operate
MR
analysis.
F
‐statistics
sensitivity
analyses
performed
evaluate
bias
reliability.
Results
When
we
set
as
exposure
outcome,
identified
nine
relationships.
males,
Coprobacter
(PIVW
=
2.01
×
10
−6
),
Ruminococcus
2
3.40
−5
Barnesiella
2.79
−2
Actinobacteria
3.25
)
Eubacterium
fissicatena
groups
3.64
associated
with
lower
levels;
Alphaproteobacteria
1.61
higher
levels.
females,
Lachnoclostridium
9.75
−3
Defluviitaleaceae
UCG011
3.67
Victivallaceae
2.23
According
results
reverse
analysis,
three
significant
found
on
microbiota.
Dorea
4.17
Clostridiales
4.36
7.44
−4
higherr
No
signifcant
heterogeneity
instrumental
variables
or
horizontal
pleiotropy
bidirectional
Conclusions
This
study
may
provide
new
insights
into
hormone‐binding
protein
levels,
well
treatment
prevention
strategies
diseases
such
abnormal
