Trajectories of health conditions and their associations with the risk of cognitive impairment among older adults: insights from a national prospective cohort study

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 10, 2024

Abstract Background The associations between trajectories of different health conditions and cognitive impairment among older adults were unknown. Our cohort study aimed to investigate the impact various trajectories, including sleep disturbances, depressive symptoms, functional limitations, multimorbidity, on subsequent risk impairment. Methods We conducted a prospective by using eight waves national data from Health Retirement Study (HRS 2002–2018), involving 4319 aged 60 years or in USA. Sleep disturbances symptoms measured Jenkins Scale Centers for Epidemiologic Research Depression (CES-D) scale, respectively. Functional limitations assessed activities daily living (ADLs) instrumental (IADLs), Multimorbidity status was self-reporting physician-diagnosed diseases. identified 8-year at four examinations 2002 2010 latent class trajectory modeling. screened participants 27-point HRS scale 2018 across waves. calculated hazard ratios (HR) Cox proportional models. Results During 25,914 person-years, 1230 developed In fully adjusted model 3, ADLs not associated with Compared low trajectory, we found that increasing (HR = 1.39; 95% CI 1.17–1.65), IADLs 1.88; 1.43–2.46), high multimorbidity 1.48; 1.16–1.88) all posed an elevated higher urban areas 2.30; 1.65–3.21) those who smoked 2.77; 1.91–4.02) (all P interaction < 0.05). Conclusions results suggest tracking functioning may be potential feasible screening method identifying

Language: Английский

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Associations between anxious-depression and cognitive change and mild cognitive impairment: HCHS/SOL Study of Latinos-Investigation of Neurocognitive Aging

International Psychogeriatrics, Journal Year: 2025, Volume and Issue: unknown, P. 100058 - 100058

Published: March 1, 2025

This study examined the associations between anxious-depression symptoms with cognitive change and prevalent mild impairment (MCI) in middle-aged older Hispanics/Latinos. Participants were enrolled Study of Latinos-Investigation Neurocognitive Aging (SOL-INCA) Hispanic Community Health Study/Study Latinos (HCHS/SOL). Anxiety depression measured at Visit 1 using 10-item Spielberger State-Trait Inventory Center for Epidemiologic Studies Depression Scale, latent class analysis applied to derive phenotypes based on items from both scales. Cognitive tests completed Visits 2 (average 7-years follow-up), where was assessed a index 2, function 2. Prevalent MCI National Institute diagnostic criteria. Regression models used investigate association function, change, MCI. In 6140 participants (mean age = 56.5 ± 8.1-years), three profiles identified: low (62 %), moderate (30 high (8 %). All associated lower scores compared low. Moderate greater prevalence (OR [95 % CI] 1.64 [1.25; 2.16] OR 1.62 [1.12; 2.33], respectively). We found no phenotype. Co-occurring elevated anxiety increased later, but not overall changes

Language: Английский

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A narrative review on insomnia and hypersomnolence within Major Depressive Disorder and bipolar disorder: A proposal for a novel psychometric protocol

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 158, P. 105575 - 105575

Published: Feb. 6, 2024

Sleep disorders have become increasingly prevalent, with many adults worldwide reporting sleep dissatisfaction. Major Depressive Disorder (MDD) and Bipolar (BD) are common conditions associated disrupted patterns such as insomnia hypersomnolence. These significantly affect the progression, severity, treatment, outcome of unipolar bipolar depression. While there is evidence a connection between depression, it remains unclear if features differ MDD BD. In light this, this narrative review aims to: (1) summarize findings on like hypersomnolence, strongly linked to BD; (2) propose novel psychometric approach assess in individuals depressive disorders. Despite seems be more influent while hypersomnolence one, no agreement. So, essential adopting comprehensive protocol for try fill gap. Understanding relationship BD crucial effective management better quality life those affected.

Language: Английский

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When mind and measurement diverge; the interplay between subjective cognitive complaints (SCCs), objective cognition, age, and depression in autistic adults

Psychiatry Research, Journal Year: 2024, Volume and Issue: 333, P. 115759 - 115759

Published: Jan. 26, 2024

While the increased incidence of dementia and subjective cognitive complaints (SCCs) suggests that autistic adults may face challenges at older age, extent to which SCCs predict (future) functioning remains uncertain. This uncertainty is complicated by associations with variables like depression. The current study aims unravel interplay depression, performance, in autism. Using a large cross-sectional cohort (n=202) non-autistic (n=247), we analyzed performance across three domains (visual memory, verbal fluency). Results showed strong significant association between depression both adults. Cognitive was not significantly associated SCCs, except for (modest) visual memory only. Follow-up regression tree analysis indicated being were considerably more predictive than objective performance. Age nor sex SCCs. These findings indicate self-reported does equal should be interpreted care, especially individuals high rates Longitudinal investigations are needed understand SCCs' role health

Language: Английский

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Heart–Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1719 - 1719

Published: Aug. 1, 2024

Arrhythmias and depression are recognized as diseases of the heart brain, respectively, both major health threats that often co-occur with a bidirectional causal relationship. The autonomic nervous system (ANS) serves crucial component heart–brain axis (HBA) pathway interoception. Cardiac activity can influence emotional states through ascending interoceptive pathways, while psychological stress precipitate arrhythmias via ANS. However, HBA interoception frameworks considered overly broad, precise mechanisms underlying relationship between remain unclear. This narrative review aims to synthesize existing literature, focusing on pathological ANS in arrhythmia integrating other potential detail interactions. In communication we emphasize considering various internal factors such genes, personality traits, stress, endocrine system, inflammation, 5-hydroxytryptamine, behavioral factors. Current research employs multidisciplinary knowledge elucidate relationships, deeper understanding these interactions help optimize clinical treatment strategies. From broader perspective, this study emphasizes importance body complex, interconnected rather than treating organs isolation. Investigating enhance our disease pathogenesis advances medical science, ultimately improving human quality life.

Language: Английский

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The Causal Association Between Blood Lead and Sleep Disorders: Evidence from National Health and Nutrition Examination Survey and Mendelian Randomization Analysis

Journal of Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: 14(2), P. 462 - 469

Published: Feb. 19, 2024

Abstract Background Poor sleep quality is a global public health concern. This study aimed to identify the risk factors for disorders and clarify their causal effects. Methods Data were obtained from National Health Nutrition Examination Survey (NHANES) Mendelian randomization (MR)-Base databases. Baseline characteristics of individuals with without compared. A multivariate logistic regression analysis was performed calculate effects each variable on disorders. Causal blood lead levels hypertension assessed using MR analysis. Results In total, 3660 enrolled in study. The prevalence self-reported 26.21%. Serum level, serum mercury retinol hypertension, daily vigorous work duration significantly higher those group than control group. After adjusting various covariates, stable models 1–4. showed that causally related (odds ratio (OR) = 1.09, 95% confidence interval (CI) 1.01–1.17, P 0.030). There no link between elevated pressure (OR 0.99, CI 0.94–1.04, 0.757). Goodness-of-fit tests sensitivity analyses used verify reliability results. Conclusions Blood positively associated an increased These findings provide novel perspective regarding protection. Taking effective measures reduce exposure may improve health.

Language: Английский

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Statistical Complexity Analysis of Sleep Stages

Entropy, Journal Year: 2025, Volume and Issue: 27(1), P. 76 - 76

Published: Jan. 16, 2025

Studying sleep stages is crucial for understanding architecture, which can help identify various health conditions, including insomnia, apnea, and neurodegenerative diseases, allowing better diagnosis treatment interventions. In this paper, we explore the effectiveness of generalized weighted permutation entropy (GWPE) in distinguishing between different from EEG signals. Using classification algorithms, evaluate feature sets derived both standard (PE) GWPE to determine set performs classifying stages, demonstrating that significantly enhances stage differentiation, particularly identifying transition N1 REM sleep. The results highlight potential as a valuable tool neurophysiology improving disorders.

Language: Английский

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Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching

Journal of Zhejiang University SCIENCE B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Language: Английский

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Development of an exercise program to improve sleep quality and mood in older adults with mild cognitive impairment

Australasian Journal on Ageing, Journal Year: 2025, Volume and Issue: 44(1)

Published: Feb. 6, 2025

Australasian Journal on AgeingVolume 44, Issue 1 e13414 LETTER TO THE EDITOR Development of an exercise program to improve sleep quality and mood in older adults with mild cognitive impairment Seung-Taek Lim, Corresponding Author Lim [email protected] orcid.org/0000-0002-0980-991X College General Education, Kookmin University, Seoul, Republic Korea Waseda Institute for Sport Sciences, Saitama, Japan Correspondence 77, Jeongneung-ro, Seongbuk-gu, Seoul 02707, South Korea. Email: protected]Search more papers by this author First published: 06 February 2025 https://doi.org/10.1111/ajag.13414Read the full textAboutPDF ToolsRequest permissionExport citationAdd favoritesTrack citation ShareShare Give accessShare text full-text accessPlease review our Terms Conditions Use check box below share version article.I have read accept Wiley Online Library UseShareable LinkUse link a article your friends colleagues. Learn more.Copy URL Share linkShare onEmailFacebookxLinkedInRedditWechat No abstract is available article. REFERENCES 1Pearson O, Uglik-Marucha N, Miskowiak KW, et al. The relationship between disturbance disorders: systematic review. J Affect Disord. 2023; 327: 207-216. 10.1016/j.jad.2023.01.114 PubMedWeb Science®Google Scholar 2Lim ST, Jung YZ, Akama T, Lee E. Physical activity amount Korean elderly population. Brain Sci. 2020; 10(11): 804. 10.3390/brainsci10110804 PubMedGoogle 3Pak VM, Onen SH, Bliwise DL, Kutner NG, Russell KL, F. Sleep disturbances MCI AD: neuroinflammation as possible mediating pathway. Front Aging Neurosci. 12: 69. 10.3389/fnagi.2020.00069 4Alghamdi BS. effect melatonin social isolation-related behavioral changes aged rats. 2022; 14:828965. 10.3389/fnagi.2022.828965 CASPubMedGoogle 5Schmidt LI, Wahl HW. Predictors performance everyday technology tasks without impairment. Gerontologist. 2019; 59(1): 90-100. 10.1093/geront/gny062 6Lee E, Kim WN. Aquatic improving immune function mental stress pre-frailty women. Women Aging. 2021; 33(6): 611-619. 10.1080/08952841.2020.1735287 7 World Health Organization. Global Recommendations Activity Health. WHO; 2010. Google Volume44, Issue1March 2025e13414 ReferencesRelatedInformation

Language: Английский

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Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson’s disease

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Feb. 12, 2025

Objective To investigate the bidirectional relationship between depression and activities of daily living (ADL) in Parkinson’s disease (PD) patients explore mediating role cognitive function over time. Methods Data from 892 PD Progression Markers Initiative (PPMI) database were included this study, depression, function, ADL measured using Geriatric Depression Scale (GDS-15), Montreal Cognitive Assessment (MoCA), Unified Disease Rating Scale, Part II (UPDRS II) respectively. The cross-lagged panel model (CLPM) was employed to analyze reciprocal ADL. Then, we explored with PD, mediation effect test carried out a bias-corrected nonparametric percentile bootstrap approach. Results predicted their subsequent ( β = 0.079, p &lt; 0.01), also 0.069, 0.05), In addition, Bootstrap analysis showed that played significant prediction 0.006, 0.074, 95%CI 0.001 ~ 0.014), 0.067, 0.013). Conclusion There is PD. Furthermore, found mediates exists Interventions aimed at enhancing could potentially lessen vicious cycle thus improving patient quality life (QOL).

Language: Английский

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