Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Current topics in behavioral neurosciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 274(8), P. 1911 - 1922
Published: Feb. 6, 2024
Language: Английский
Citations
4
BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 2, 2025
The high comorbidity and symptom overlap of generalized anxiety disorder (GAD), posttraumatic stress (PTSD), social (SAD), has led to the study their shared disorder-specific neural substrates. However, morphometric similarity network (MSN) differences among these disorders remain unknown. MSN derived from T1-weighted images in patients GAD, PTSD, SAD, health controls (HC) using a Siemens 3T magnetic resonance imaging system. Covariance analysis post hoc tests were used investigate group differences. In addition, relationship between clinical characteristics was analyzed. Increased (MS) left bankssts (BA22, superior temporal cortex, STC) right precentral gyrus, decreased MS gyrus cuneus_part1/part2, rostral middle frontal cortex (rMFC) STC common GAD PTSD relative HC SAD. Compared other three groups, SAD exhibited alterations increased rMFC STC, cuneus inferior parietal cortex. Additionally, regional found compared A mild positive correlation value Hamilton Anxiety Rating Scale scores (uncorrected p = 0.041) PTSD. Our provides first evidence for distinct brain abnormalities underlying pathophysiology which may aid differential diagnosis determining potential intervention targets.
Language: Английский
Citations
0
Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Generalized anxiety disorder (GAD) frequently emerges during childhood or adolescence, yet, few studies have examined functional connectivity differences in youth GAD. Functional MRI of adult GAD implicated multiple brain regions; however, frequent examination individual seed regions and/or networks has limited a holistic view GAD-associated differences. The current study therefore used resting-state fMRI data from the Adolescent Brain Cognitive Development to investigate with across cortical and subcortical GAD, considering diagnosis changes two assessment periods. Within- between-network 164 3158 healthy controls for 6 was assessed using linear mixed effect models. Changes between baseline 2-year follow-up were then compared subjects with: continuous at not (GAD-remitters), (GAD-converters), controls. Youth showed greater within-ventral attention network (VAN) connectivity, hyperconnectivity amygdala cingulo-opercular network, striatal cingulo-opercular, default mode, salience (FDR p<0.05). Within-VAN decreased GAD-remitters follow-up. Sensitivity analyses revealed that these patterns observed major depressive (n=19), separation (n=33), social (n=111) without Results indicate adolescence is associated altered within-VAN hyperconnectivity, particular, clinically-significant GAD-specific symptoms.
Language: Английский
Citations
0
Brain Research Bulletin, Journal Year: 2024, Volume and Issue: 211, P. 110946 - 110946
Published: April 12, 2024
Post-traumatic stress disorder (PTSD) is associated with abnormalities in the processing and regulation of emotion as well cognitive deficits. This study evaluated differential brain activation patterns emotional distractors during working memory (WM) maintenance for human faces between patients PTSD healthy controls (HCs) assessed relationship changes by opposing effects distraction types gray matter volume (GMV). Twenty-two twenty-two HCs underwent T1-weighted magnetic resonance imaging (MRI) event-related functional MRI (fMRI), respectively. Event-related fMRI data were recorded while subjects performed a delayed-response WM task face trauma-related distractors. Compared to HCs, showed significantly reduced GMV inferior frontal gyrus (IFG) (p < 0.05, FWE-corrected). For distractor trial, decreased activities superior IFG compared The lower accuracy scores slower reaction times recognition increased activity STG trial was observed Such may be linked neural mechanisms impairments both control confusable ability distraction.
Language: Английский
Citations
3
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: Dec. 5, 2023
Post-traumatic stress disorder (PTSD) is a stress-associated complex and debilitating psychiatric due to an imbalance of neurotransmitters in response traumatic events or fear. PTSD characterized by re-experiencing, avoidance behavior, hyperarousal, negative emotions, insomnia, personality changes, memory problems following exposure severe trauma. However, the biological mechanisms symptomatology underlying this are still largely unknown poorly understood. Considerable evidence shows that results from dysfunction highly conserved brain systems involved regulating stress, anxiety, fear, reward circuitry. This review provides contemporary update about PTSD, including new data clinical preclinical literature on fear consolidation extinction processes. First, we present overview well-established laboratory models discuss their translational value for finding various treatments PTSD. We then highlight research progress neural circuits extinction-related prefrontal cortex, hippocampus, amygdala. further describe different molecular mechanisms, GABAergic, glutamatergic, cholinergic, neurotropic signaling, responsible structural functional changes during acquisition processes
Language: Английский
Citations
8
Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 9(6), P. 571 - 579
Published: March 11, 2024
Language: Английский
Citations
1
Neuroscience, Journal Year: 2024, Volume and Issue: 558, P. 50 - 57
Published: Aug. 17, 2024
Language: Английский
Citations
1
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1285 - 1285
Published: Dec. 21, 2024
Substance use disorders (SUDs) and anxiety (ADs) are highly comorbid, a co-occurrence linked to worse clinical outcomes than either condition alone. While the neurobiological mechanisms involved in SUDs intensively studied separately, underlying their comorbidity remain an emerging area of interest. This narrative review explores processes this comorbidity, using Research Domain Criteria (RDoC) framework map disruptions positive valence, negative cognitive systems across three stages addiction cycle: binge/intoxication, withdrawal/negative affect, preoccupation/anticipation. Anxiety substance play reciprocal role at each stage addiction, marked by significant psychosocial impairment dysregulation brain. A more thorough understanding neural underpinnings comorbid will contribute tailored effective therapeutic interventions assessments.
Language: Английский
Citations
1
Journal of Psychiatric Research, Journal Year: 2023, Volume and Issue: 170, P. 225 - 236
Published: Dec. 22, 2023
Language: Английский
Citations
3