Neuromodulation of Fear and Anxiety Circuits

Current topics in behavioral neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Long-term follow-up of brain regional changes and the association with cognitive impairment in quarantined COVID-19 survivors

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер 274(8), С. 1911 - 1922

Опубликована: Фев. 6, 2024

Язык: Английский

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Shared and distinct morphometric similarity network abnormalities in generalized anxiety disorder, posttraumatic stress disorder and social anxiety disorder

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 2, 2025

The high comorbidity and symptom overlap of generalized anxiety disorder (GAD), posttraumatic stress (PTSD), social (SAD), has led to the study their shared disorder-specific neural substrates. However, morphometric similarity network (MSN) differences among these disorders remain unknown. MSN derived from T1-weighted images in patients GAD, PTSD, SAD, health controls (HC) using a Siemens 3T magnetic resonance imaging system. Covariance analysis post hoc tests were used investigate group differences. In addition, relationship between clinical characteristics was analyzed. Increased (MS) left bankssts (BA22, superior temporal cortex, STC) right precentral gyrus, decreased MS gyrus cuneus_part1/part2, rostral middle frontal cortex (rMFC) STC common GAD PTSD relative HC SAD. Compared other three groups, SAD exhibited alterations increased rMFC STC, cuneus inferior parietal cortex. Additionally, regional found compared A mild positive correlation value Hamilton Anxiety Rating Scale scores (uncorrected p = 0.041) PTSD. Our provides first evidence for distinct brain abnormalities underlying pathophysiology which may aid differential diagnosis determining potential intervention targets.

Язык: Английский

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Resting State Cortical Network and Subcortical Hyperconnectivity in Youth With Generalized Anxiety Disorder in the ABCD Study

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Generalized anxiety disorder (GAD) frequently emerges during childhood or adolescence, yet, few studies have examined functional connectivity differences in youth GAD. Functional MRI of adult GAD implicated multiple brain regions; however, frequent examination individual seed regions and/or networks has limited a holistic view GAD-associated differences. The current study therefore used resting-state fMRI data from the Adolescent Brain Cognitive Development to investigate with across cortical and subcortical GAD, considering diagnosis changes two assessment periods. Within- between-network 164 3158 healthy controls for 6 was assessed using linear mixed effect models. Changes between baseline 2-year follow-up were then compared subjects with: continuous at not (GAD-remitters), (GAD-converters), controls. Youth showed greater within-ventral attention network (VAN) connectivity, hyperconnectivity amygdala cingulo-opercular network, striatal cingulo-opercular, default mode, salience (FDR p<0.05). Within-VAN decreased GAD-remitters follow-up. Sensitivity analyses revealed that these patterns observed major depressive (n=19), separation (n=33), social (n=111) without Results indicate adolescence is associated altered within-VAN hyperconnectivity, particular, clinically-significant GAD-specific symptoms.

Язык: Английский

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Brain morphological changes and functional neuroanatomy related to cognitive and emotional distractors during working memory maintenance in post-traumatic stress disorder

Brain Research Bulletin, Год журнала: 2024, Номер 211, С. 110946 - 110946

Опубликована: Апрель 12, 2024

Post-traumatic stress disorder (PTSD) is associated with abnormalities in the processing and regulation of emotion as well cognitive deficits. This study evaluated differential brain activation patterns emotional distractors during working memory (WM) maintenance for human faces between patients PTSD healthy controls (HCs) assessed relationship changes by opposing effects distraction types gray matter volume (GMV). Twenty-two twenty-two HCs underwent T1-weighted magnetic resonance imaging (MRI) event-related functional MRI (fMRI), respectively. Event-related fMRI data were recorded while subjects performed a delayed-response WM task face trauma-related distractors. Compared to HCs, showed significantly reduced GMV inferior frontal gyrus (IFG) (p < 0.05, FWE-corrected). For distractor trial, decreased activities superior IFG compared The lower accuracy scores slower reaction times recognition increased activity STG trial was observed Such may be linked neural mechanisms impairments both control confusable ability distraction.

Язык: Английский

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The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Дек. 5, 2023

Post-traumatic stress disorder (PTSD) is a stress-associated complex and debilitating psychiatric due to an imbalance of neurotransmitters in response traumatic events or fear. PTSD characterized by re-experiencing, avoidance behavior, hyperarousal, negative emotions, insomnia, personality changes, memory problems following exposure severe trauma. However, the biological mechanisms symptomatology underlying this are still largely unknown poorly understood. Considerable evidence shows that results from dysfunction highly conserved brain systems involved regulating stress, anxiety, fear, reward circuitry. This review provides contemporary update about PTSD, including new data clinical preclinical literature on fear consolidation extinction processes. First, we present overview well-established laboratory models discuss their translational value for finding various treatments PTSD. We then highlight research progress neural circuits extinction-related prefrontal cortex, hippocampus, amygdala. further describe different molecular mechanisms, GABAergic, glutamatergic, cholinergic, neurotropic signaling, responsible structural functional changes during acquisition processes

Язык: Английский

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Anxiety Symptoms in Young Children Are Associated With a Maladaptive Neurobehavioral Profile of Error Responding

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2024, Номер 9(6), С. 571 - 579

Опубликована: Март 11, 2024

Язык: Английский

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Neural correlates of anxiety in adult-onset isolated dystonia

Neuroscience, Год журнала: 2024, Номер 558, С. 50 - 57

Опубликована: Авг. 17, 2024

Язык: Английский

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The Limbic System in Co-Occurring Substance Use and Anxiety Disorders: A Narrative Review Using the RDoC Framework

Brain Sciences, Год журнала: 2024, Номер 14(12), С. 1285 - 1285

Опубликована: Дек. 21, 2024

Substance use disorders (SUDs) and anxiety (ADs) are highly comorbid, a co-occurrence linked to worse clinical outcomes than either condition alone. While the neurobiological mechanisms involved in SUDs intensively studied separately, underlying their comorbidity remain an emerging area of interest. This narrative review explores processes this comorbidity, using Research Domain Criteria (RDoC) framework map disruptions positive valence, negative cognitive systems across three stages addiction cycle: binge/intoxication, withdrawal/negative affect, preoccupation/anticipation. Anxiety substance play reciprocal role at each stage addiction, marked by significant psychosocial impairment dysregulation brain. A more thorough understanding neural underpinnings comorbid will contribute tailored effective therapeutic interventions assessments.

Язык: Английский

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Shared and distinctive dysconnectivity patterns underlying pure generalized anxiety disorder (GAD) and comorbid GAD and depressive symptoms

Journal of Psychiatric Research, Год журнала: 2023, Номер 170, С. 225 - 236

Опубликована: Дек. 22, 2023

Язык: Английский

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