The effect of the earliest COVID-19 outbreak on survival in uninfected advanced NSCLC patients receiving chemotherapy in Jiangsu Province, China: A retrospective cohort study DOI Creative Commons

Heng Lu,

Yue Wang,

Guoqiang Feng

et al.

Medicine, Journal Year: 2023, Volume and Issue: 102(39), P. e34559 - e34559

Published: Sept. 29, 2023

Coronavirus disease 2019 (COVID-19) is still rampant and uncontrolled across the globe. China's strict epidemic prevention measures have had an impact on treatment in patients with non-small cell lung cancer (NSCLC). The aim of this study to explore COVID-19 outbreak uninfected NSCLC patients. chemotherapeutic efficacy survival 89 advanced were retrospectively analyzed. endpoints overall (OS), progression-free (PFS), response rate. Forty forty-nine received chemotherapy during nonoutbreak periods, respectively. Mean delay time was 12.8 months for stage versus 5.68 (P = .003). There no significant difference rates discontinuation between 2 groups .055 .239). Significant not detected median OS (15.8 months) 16.0 (adjusted hazard ratio, 1.058; 95% confidence interval, 0.593-1.888; P .849); Median PFS 7.9 10.3 0.878; interval 0.513-1.503; .634). also statistical control rate .137). earliest receiving chemotherapy. However, mean prolonged outbreak.

Language: Английский

Investigating the civic emotion dynamics during the COVID-19 lockdown: Evidence from social media DOI
Qianlong Zhao, Yuhao He,

Yuankai Wang

et al.

Sustainable Cities and Society, Journal Year: 2024, Volume and Issue: 107, P. 105403 - 105403

Published: April 5, 2024

Language: Английский

Citations

14
Purpose in life and stress: An individual-participant meta-analysis of 16 samples DOI Creative Commons
Angelina R. Sutin, Martina Luchetti, Yannick Stéphan

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 345, P. 378 - 385

Published: Oct. 30, 2023

Language: Английский

Citations

12
Resilience reemerged in sustainable development goals: A perspective on easing COVID-19 restrictions in China DOI

Zizhao Ni,

Wenwu Zhao, Jinyu Wang

et al.

Applied Geography, Journal Year: 2025, Volume and Issue: 178, P. 103573 - 103573

Published: March 4, 2025

Language: Английский

Citations

0
Development and application of a UHPLC-MS/MS method for the simultaneous determination of firmonertinib and its main metabolite AST-5902 in rat plasma: a study on the in vivo drug interaction between firmonertinib and paxlovid DOI Creative Commons

Peng-fei Tang,

Su‐su Bao, Wenyan Xie

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

Due to the potential occurrence of drug interactions, combined application firmonertinib and paxlovid carries a relatively high risk. Nevertheless, as now, there has been no comprehensive research on interaction between paxlovid. Our aim was establish validate an accurate, stable, rapid simple UPLC-MS/MS method for simultaneous determination its metabolite AST-5902 in rat plasma, which applied study vivo Gefitinib selected internal standard. After protein precipitation plasma samples with acetonitrile, separation carried out Shimadzu LC-20AT UHPLC. The chromatographic column Shim-pack Volex PFPP (50 mm × 2.1 mm, 1.8 μm), mobile phase composed 0.1% formic acid - water methanol. Mass spectrometry detection performed using 8,040 mass spectrometer ESI+ MRM mode. precision, accuracy, recovery matrix effect this were detected. linearity stability assessed. Subsequently, parent ions typical fragment firmonertinib, IS are respectively m/z 569.25 → 72.15, 555.50 498.10 447.25→ 128.20. selectivity, specificity, linearity, recovery, effect, accuracy precision all adequately verified. results showed that when paxlovid, AUC Cmax significantly increased, while AUC, Tmax, decreased. established UHPLC-MS/MS is simple. Paxlovid exhibit significant inhibitory metabolism rats.

Language: Английский

Citations

0
Association of anxiety, depression symptoms and sleep quality with chronic kidney disease among older Chinese DOI Creative Commons
Jing Huang, Yanyan Mao,

Xuetao Zhao

et al.

Medicine, Journal Year: 2023, Volume and Issue: 102(43), P. e35812 - e35812

Published: Oct. 27, 2023

This study aimed to explore the association of anxiety, depression symptoms and sleep quality with chronic kidney disease (CKD) among older Chinese adults. A total 1025 participants from Longitudinal Healthy Longevity Survey (CLHLS, 2011-2012) were included in our study. The Generalized Anxiety Disorder scale was used assess anxiety Center for Epidemiologic Studies Depression Scale evaluate depressive symptoms. Logistic regression models conducted odds ratios (ORs) 95% confidential intervals (CIs). We found that poor positively associated albuminuria, impaired estimated glomerular filtration (eGFR) CKD, after adjusting other covariates. For symptom, ORs CIs 1.20 (1.15-1.38) 1.16 (1.12-1.35) eGFR 1.18 (1.12-1.36) respectively. 1.15 (1.05-1.23) 1.14 (1.05-1.20) (1.05-1.22) Compared good quality, OR CI 1.12 (1.04-1.35) 1.10 (1.02-1.30) 1.11 (1.03-1.32) And positive more evident females, body mass index ≥ 28, smoking drinking Anxiety, are CKD. Future cohort studies needed confirm results.

Language: Английский

Citations

9
AI as your ally: The effects of AI‐assisted venting on negative affect and perceived social support DOI Open Access
Meilan Hu,

Xavier Cheng Wee Chua,

Shu Fen Diong

et al.

Applied Psychology Health and Well-Being, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

In recent years, artificial intelligence (AI) chatbots have made significant strides in generating human-like conversations. With AI's expanding capabilities mimicking human interactions, its affordability and accessibility underscore the potential of AI to facilitate negative emotional disclosure or venting. The study's primary objective is highlight benefits AI-assisted venting by comparing effectiveness through a traditional journaling platform reducing affect increasing perceived social support. We conducted pre-registered within-subject experiment involving 150 participants who completed both conditions with counterbalancing wash-out period 1-week between conditions. Results from frequentist Bayesian dependent samples t-test revealed that effectively reduced high medium arousal such as anger, frustration fear. However, condition did not experience increase support loneliness, suggesting perceive effective assistance This study demonstrates promising role improving individuals' well-being, serving catalyst for broader discussion on evolving psychological implications.

Language: Английский

Citations

3
From academia to addiction: understanding the mechanism behind how academic stress fuels social media addiction in PhD students DOI
Along He, Li Zhu

Current Psychology, Journal Year: 2024, Volume and Issue: 43(34), P. 27944 - 27956

Published: Aug. 16, 2024

Language: Английский

Citations

1
Reflecting on relaxing zero-COVID and moving forward with positivity: A population-based quantitative and qualitative study DOI
Ruihua Li, Chuanning Huang,

Beier Guan

et al.

Health Policy and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 100929 - 100929

Published: Oct. 1, 2024

Language: Английский

Citations

0
Who Can Help Me? Citizens’ Help-Seeking on Weibo During the Shanghai Lockdown DOI
Difan Guo, Shaoqiang Liu, Yao Sun

et al.

Disaster Medicine and Public Health Preparedness, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 1, 2024

Abstract Objective In the context of Omicron-induced lockdown in Shanghai, this paper investigated appeals for assistance by citizens on Weibo, aiming to understand their principal challenges and immediate needs. Methods This collected Weibo posts ( N = 1040) containing keyword “Shanghai Anti-epidemic Help” during citywide lockdown. The online help requests from Shanghai were analyzed across 7 dimensions, including sought, level urgency, recipient, intended beneficiary help, expression, position, emotion. Results study found that most common related social isolation, specifically areas home community (34.81%), isolation (10.86%), personal freedom (7.31%). Of all requests, 11.83% deemed very urgent. Most sent out a plea Internet users (56.06%), primarily requesting themselves (26.25%) or families (27.60%). Conclusions freedom, food, medical care frequently sought public, public’s positions emotions pessimistic. relevant findings revealed needs status city closure, providing reference emergency preparedness public health events emergencies.

Language: Английский

Citations

0
The effect of the earliest COVID-19 outbreak on survival in uninfected advanced NSCLC patients receiving chemotherapy in Jiangsu Province, China: A retrospective cohort study DOI Creative Commons

Heng Lu,

Yue Wang,

Guoqiang Feng

et al.

Medicine, Journal Year: 2023, Volume and Issue: 102(39), P. e34559 - e34559

Published: Sept. 29, 2023

Coronavirus disease 2019 (COVID-19) is still rampant and uncontrolled across the globe. China's strict epidemic prevention measures have had an impact on treatment in patients with non-small cell lung cancer (NSCLC). The aim of this study to explore COVID-19 outbreak uninfected NSCLC patients. chemotherapeutic efficacy survival 89 advanced were retrospectively analyzed. endpoints overall (OS), progression-free (PFS), response rate. Forty forty-nine received chemotherapy during nonoutbreak periods, respectively. Mean delay time was 12.8 months for stage versus 5.68 (P = .003). There no significant difference rates discontinuation between 2 groups .055 .239). Significant not detected median OS (15.8 months) 16.0 (adjusted hazard ratio, 1.058; 95% confidence interval, 0.593-1.888; P .849); Median PFS 7.9 10.3 0.878; interval 0.513-1.503; .634). also statistical control rate .137). earliest receiving chemotherapy. However, mean prolonged outbreak.

Language: Английский

Citations

0