Neuropsychiatric Disease and Treatment,
Journal Year:
2024,
Volume and Issue:
Volume 20, P. 1041 - 1048
Published: May 1, 2024
Purpose:
To
determine
whether
perioperative
esketamine
use
decreases
the
risk
of
postpartum
depression
(PPD).
Methods:
Online
search
PubMed,
Web
Science,
and
Embase
was
conducted
to
identify
relevant
studies.
Key
words
for
included,
but
were
not
limited
to,
depression,
esketamine,
clinical
trials.
The
mean
standard
deviation
Edinburgh
Postnatal
Depression
Scale
(EPDS)
scores
extracted
from
studies
as
primary
parameters.
Results:
literature
identified
226
articles,
which
5
met
criteria
enrolled
in
study.
In
total,
886
patients
taken
into
analysis.
EPDS
group
lower
than
those
control
at
early
stage
puerperium
(WMD=−
2.05,
95%
CI:
−
3.77,
0.34,
p
=0.019),
whereas
there
no
significant
difference
middle
later
stages
1.41,
2.86,
0.04,
=0.056).
sensitivity
analyses
indicated
that
result
stable,
it
unreliable
stages.
results
Egger's
test
publication
bias.
Conclusion:
Perioperative
contributes
a
PPD
further
verify
this
conclusion,
more
high-quality
are
required.
Keywords:
pregnant
women,
mental
health
BMC Psychiatry,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 11, 2025
Anxiety
disorders
are
increasing
worldwide,
untreated
anxiety
is
linked
to
maternal
and
child
health
outcomes.
The
purpose
of
this
study
test
psychometric
properties
the
Perinatal
Screening
Scale
(PASS)
among
Chinese
women.
PASS
was
translated
into
following
Beaton's
intercultural
debugging
guide.
A
total
494
women
in
antenatal
postnatal
phase
participated
(
268
186
)
were
recruited
between
March
2023
July
from
two
hospitals
Sichuan
Province,
China.
instruments
included
demographic
characteristics
form,
PASS,
Edinburgh
Postnatal
Depression
(EPDS),
Generalized
Disorder-7
(GAD-7).
confirmatory
factor
analysis
(CFA),
internal
consistency
reliability
convergent
validity
assessed.
mean
age
participant
31.67
years
(SD
=
3.78;
range
23
49).
CFA
showed
that
four-factor
model
Chinese-PASS
had
an
excellent
fit
data
χ2
1481.2477;
df
425;
χ2/df
3.485;
RMSEA
0.071;
CFI
0.871;
NNFI
0.828;
TLI
0.859;
IFI
0.871).
Cronbach's
alpha
coefficient
scale
0.950,
split-half
0.907.
significantly
correlated
with
EPDS
(r
0.732)
GAD-7
0.763).
area
under
ROC
curve
for
scores
0.91
(SE
0.01;
95%
CI
0.89–0.94).
At
cut-off
score
≥
19.5,
sensitivity
0.87.
0.89
0.02;
0.86–0.92).
3.5,
0.82.
result
show
a
reasonably
adequate
can
be
used
screen
disorder
during
perinatal
period.
BMC Surgery,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 8, 2025
Postoperative
pain
and
psychological
well-being
in
postpartum
women
following
cesarean
section
are
critical
for
optimal
maternal
recovery.
Traditional
analgesics
often
have
limitations
side
effects,
prompting
the
need
alternative
solutions.
This
study
evaluates
impact
of
an
esketamine
intravenous
analgesic
pump
on
postoperative
status
section.
A
comprehensive
retrospective
evaluation
was
conducted
at
our
institution
from
October
2021
to
July
2023,
including
168
patients
who
underwent
delivery.
The
observation
group
(n
=
82)
received
via
pump,
while
control
86)
traditional
therapy.
Data
collected
included
demographic
information,
surgical
details,
(assessed
using
Visual
Analog
Scale,
VAS),
Edinburgh
Postnatal
Depression
EPDS),
recovery
metrics,
adverse
reactions.
demonstrated
consistently
lower
VAS
scores
all
time
points
compared
group,
indicating
superior
control.
EPDS
were
significantly
3,
5,
14
days
postoperatively,
suggesting
better
outcomes.
incidence
depression
also
days.
Recovery
metrics
such
as
first
ambulation,
flatus,
initiation
lactation
improved
group.
There
no
significant
differences
reactions
between
groups.
use
Esketamine
Intravenous
Analgesic
Pump
reduces
within
It
promotes
early
breastfeeding
without
reactions,
making
it
a
valuable
addition
care.
Frontiers in Psychiatry,
Journal Year:
2025,
Volume and Issue:
16
Published: April 15, 2025
Background
Postoperative
depression
(POD)
represents
a
serious
complication
in
surgical
patients,
exacerbating
morbidity
and
mortality
rates
while
imposing
substantial
economic
burden
on
healthcare
systems.
Despite
its
widespread
clinical
use,
the
role
of
esketamine,
an
NMDA
receptor
antagonist
with
rapid
antidepressant
effects,
remains
understudied
perioperative
settings.
Therefore,
we
conducted
systematic
review
meta-analysis
to
assess
efficacy
esketamine
postoperative
depression.
To
evaluate
effect
incidence
severity
different
types
surgery
by
randomized
controlled
trial,
investigate
whether
can
effectively
reduce
score
short
long
term
after
promote
application
analgesia-antidepressant
combination.
Method
Searched
PubMed,
Cochrane
Library,
Web
Science,
Medline
identify
trials
using
drug
analyzed
data
Review
Manager
5.3.
Results
We
included
total
8
involving
1724
patients
who
met
criteria.
The
revealed
that
treatment,
compared
control
groups,
significantly
reduced
POD.
Improvements
were
observed
at
1
week
(RD
-0.09,
95%
CI
[-0.13,
-0.05],
P
<
0.0001,
I²=84%),
2
weeks
-0.08,
-0.03],
0.00001,
I²=97%),
long-term
follow-up
-0.06,
[-0.10,
-0.02],
P=0.0002,
I²=79%).
Conclusion
Esketamine
demonstrates
reducing
POD
severity,
although
use
is
associated
increased
risk
adverse
effects.
Also,
method
injection,
duration
administration
number
doses
may
have
results.
further
exploration
appropriate
dosing
regimens
multi-modal
strategies
necessary
mitigate
Systematic
registration
https://www.crd.york.ac.uk/PROSPERO/
,
identifier
CRD42024506329.
Neuropsychiatric Disease and Treatment,
Journal Year:
2024,
Volume and Issue:
Volume 20, P. 1041 - 1048
Published: May 1, 2024
Purpose:
To
determine
whether
perioperative
esketamine
use
decreases
the
risk
of
postpartum
depression
(PPD).
Methods:
Online
search
PubMed,
Web
Science,
and
Embase
was
conducted
to
identify
relevant
studies.
Key
words
for
included,
but
were
not
limited
to,
depression,
esketamine,
clinical
trials.
The
mean
standard
deviation
Edinburgh
Postnatal
Depression
Scale
(EPDS)
scores
extracted
from
studies
as
primary
parameters.
Results:
literature
identified
226
articles,
which
5
met
criteria
enrolled
in
study.
In
total,
886
patients
taken
into
analysis.
EPDS
group
lower
than
those
control
at
early
stage
puerperium
(WMD=−
2.05,
95%
CI:
−
3.77,
0.34,
p
=0.019),
whereas
there
no
significant
difference
middle
later
stages
1.41,
2.86,
0.04,
=0.056).
sensitivity
analyses
indicated
that
result
stable,
it
unreliable
stages.
results
Egger's
test
publication
bias.
Conclusion:
Perioperative
contributes
a
PPD
further
verify
this
conclusion,
more
high-quality
are
required.
Keywords:
pregnant
women,
mental
health
