Plastic harmful ingredients reduce the level of neurofilament light chain protein

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117670 - 117670

Published: Jan. 1, 2025

Population exposure to plastics is increasing, and plasticizers are frequently detected in humans as important ingredients of plastic products. However, patterns harmful their effects on neurofilament light chain (NFL), a marker active brain pathology, currently inconclusive. Herein, we employed range statistical methods thoroughly investigate the impact 24 hazardous varying NFL concentrations blood general population 533 participants. Generalized linear model revealed positive correlation between Mono-isononyl phthalate Mono (2-Ethyl- 5-Hydroxyhexyl) Phthalate (MEHHP) with NFL. Furthermore, significant dose-response relationship was observed MEHHP NFL, while Butyl paraben (Hydroxy-Isononyl) Ester exhibited distinct "inverted U-shaped" nonlinear pattern Additionally, Weighted Quantile Sum allowed us identify mixed all ingredients, Mono(2-Ethyl-5-Oxohexyl) Phthalate, Mono-isobutyl phthalate, Mon butyl Propyl Triclosan occupying prominent positions. Finally, latent profile analysis categorized exposures into high, medium, low patterns, confirming that higher posed risk factor for elevated levels blood. Exposure significantly increases present contributes early detection intervention reduce incidence neurodevelopmental disorder.

Language: Английский

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Associations between blood ethylene oxide levels and serum neurofilament light chain concentrations in adults: evidence from the NHANES

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 21, 2025

Ethylene oxide (EO) is a widely used industrial chemical recognized for its health risks, potentially posing threats to human health, including neurotoxicity, cardiovascular damage, and carcinogenic effects. Neurofilament light chain (NfL) protein released into the blood following axonal damage. To date, no studies have investigated relationship between EO exposure NfL levels. Therefore, we selected 5,902,013-2014 National Health Nutrition Examination Survey (NHANES) participants examine levels serum concentrations. According data from NHANES, this cross-sectional study multiple regression analysis, subgroup smooth curve fitting explore chain. The results of present indicate positive association Greater was correlated with increased concentrations in fully adjusted model [β = 0.28, 95% CI (0.16, 0.40)]. Each additional unit linked 0.28-unit increase level. Additionally, IN sensitivity analysis by changing continuous variable categorical variable. increasing tertiles Compared lowest tertile, highest tertile associated (β 0.16, 0.40; P trend 0.0138). Our link higher sample US adults aged 20 years older. Although directionality clinical significance observation remain uncertain, our emphasize importance conducting investigate possible causes neurological effects adults.

Language: Английский

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Predictors of mood disturbance in older adults: a longitudinal cohort study.

PubMed, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

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Association of serum neurofilament light chain and bone mineral density in adults

BMC Musculoskeletal Disorders, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 21, 2025

Language: Английский

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Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Background Vitamins are essential micronutrients for the prevention and treatment of neurodegenerative diseases. The objectives present study were to evaluate association between dietary vitamin intake cognitive function in elderly adults explore potential impact serum neurofilament light chain (NfL) concentration. Methods Data from 468 individuals, including information on consumption 10 vitamins, used. Cognitive performance was assessed according a composite Z-score Animal Fluency Test (AFT), Consortium Establish Registry Alzheimer’s Disease (CERAD), Digit Symbol Substitution (DSST). Serum NfL levels measured using highly sensitive immunoassay. Bayesian kernel machine regression (BKMR) models used estimate combined effects mixtures function. Results In both single- multiple-vitamin models, individuals with higher K exhibited greater global function, compared those lower intake. BKMR revealed positive associations AFT Z-scores, DSST Z-scores. Individuals third tertile than first (regression coefficient, β = −0.16 [95% confidence interval −0.29 −0.02]; p 0.023). mediated (8.73%). Conclusion Vitamin positively associated participants. may be by

Language: Английский

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Association of frailty and serum neurofilament light chain levels: the mediating role of estimated glomerular filtration rate

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 11, 2024

Background Both frailty and elevated serum neurofilament light chain (sNfL) levels are linked to cognitive impairment. However, evidence of their relationship is lacking, whether it was mediated by renal function unknown. This study aimed investigate the association between sNfL in a representative U.S. population, explore potential mediating role estimated glomerular filtration rate (eGFR) this relationship. Methods Data from 1,782 participants aged 20–75 years 2013–2014 National Health Nutrition Examination Survey (NHANES) were analyzed. Frailty assessed using 49-item index, categorized as non-frail, pre-frail, or frail. measured acoustic emission technology. Multivariable linear regression models restricted cubic spline analyses employed examine associations frailty, eGFR, levels. Mediation analysis conducted evaluate eGFR frailty-sNfL Results The prevalence pre-frailty 45.39 11.60%, respectively. A significant positive observed score (adjusted β : 39.97, SE: 11.07, p = 0.003), with confirmed analysis. Frail individuals had significantly higher compared non-frail 11.86, 5.42, 0.04). negatively associated β: -0.23, 0.05, < 0.001). revealed that accounted for 12.52% total effect on ( 0.0001). Conclusion demonstrates partially These findings suggest may serve biomarker frailty-related neuronal damage highlight importance kidney association. Further research warranted clinical implications these assessment management strategies.

Language: Английский

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Neurofilament Light Protein as a Biomarker in Severe Mental Disorders: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 61 - 61

Published: Dec. 25, 2024

Severe mental disorders (SMDs), such as schizophrenia (SZ), bipolar disorder (BD), and major depressive (MDD), are heterogeneous psychiatric diseases that impose a significant societal burden due to their chronic disabling nature. There no objective reliable diagnostic tests for SMDs; thus, there is an urgent need specific biomarkers improve diagnosis, treatment, resource allocation. Neurofilaments, found in cerebrospinal fluid blood, offer prognostic potential. This review discusses the link between neurofilament light chain (NfL) involvement neurodegenerative gives insights into value of NfL SMDs. systematic searched PubMed, Scopus, Web Science databases answer research question “Are levels higher individuals with SMDs compared healthy controls?” using terms related neurofilament, SMDs, SZ, BD, depression. Of 8577 initial papers, 115 were relevant. After exclusions manual additions, 17 articles included. Studies indicate elevated controls, suggesting its potential biomarker distinguishing from disorders. However, further longitudinal needed confirm reliability differential disease prediction, treatment assessment psychiatry.

Language: Английский

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