Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Nov. 5, 2023
Abstract
Marine
resources
in
unique
marine
environments
provide
abundant,
cost-effective
natural
biomaterials
with
distinct
structures,
compositions,
and
biological
activities
compared
to
terrestrial
species.
These
marine-derived
raw
materials,
including
polysaccharides,
protein
components,
fatty
acids,
minerals,
etc.,
have
shown
great
potential
preparing,
stabilizing,
or
modifying
multifunctional
nano-/micro-systems
are
widely
applied
drug
delivery,
theragnostic,
tissue
engineering,
etc.
This
review
provides
a
comprehensive
summary
of
the
most
current
biomaterial-based
developed
over
past
three
years,
primarily
focusing
on
therapeutic
delivery
studies
highlighting
their
cure
variety
diseases.
Specifically,
we
first
provided
detailed
introduction
physicochemical
characteristics
biocomponents
state.
Furthermore,
assembly
processes,
functionalities
each
building
block,
thorough
evaluation
pharmacokinetics
pharmacodynamics
advanced
systems
effects
molecular
pathophysiological
processes
were
fully
elucidated.
Finally,
list
unresolved
issues
pivotal
challenges
applications,
such
as
standardized
distinction
long-term
biosafety
vivo,
feasibility
scale-up,
was
presented.
is
expected
serve
roadmap
for
fundamental
research
facilitate
rational
design
diverse
emerging
applications.
Graphical
Journal of Pharmaceutical Analysis,
Journal Year:
2022,
Volume and Issue:
13(3), P. 239 - 254
Published: Dec. 30, 2022
Flavonoids
such
as
baohuoside
I
and
icaritin
are
the
major
active
compounds
in
Epimedii
Folium
(EF)
possess
excellent
therapeutic
effects
on
various
diseases.
Encouragingly,
2022,
soft
capsules
were
approved
to
reach
market
for
treatment
of
hepatocellular
carcinoma
(HCC)
by
National
Medical
Products
Administration
(NMPA)
China.
Moreover,
recent
studies
demonstrate
that
can
serve
immune-modulating
agent
exert
anti-tumor
effects.
Nonetheless,
both
production
efficiency
clinical
applications
epimedium
flavonoids
have
been
restrained
because
their
low
content,
poor
bioavailability,
unfavorable
vivo
delivery
efficiency.
Recently,
strategies,
including
enzyme
engineering
nanotechnology,
developed
increase
productivity
activity,
improve
efficiency,
enhance
flavonoids.
In
this
review,
structure-activity
relationship
is
described.
Then,
enzymatic
strategies
increasing
highly
discussed.
The
nanomedicines
overcoming
barriers
improving
diseases
summarized.
Finally,
challenges
an
outlook
translation
proposed.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: May 19, 2023
Chito-oligosaccharides
(COS),
derived
from
chitosan
(CH),
are
attracting
increasing
attention
as
drug
delivery
carriers
due
to
their
biocompatibility,
biodegradability,
and
mucoadhesive
properties.
Grafting,
the
process
of
chemically
modifying
CH/COS
by
adding
side
chains,
has
been
used
improve
performance
enhancing
stability,
targeted
delivery,
controlled
release.
In
this
review,
we
aim
provide
an
in-depth
study
on
recent
advances
in
grafting
for
multifarious
applications.
Moreover,
various
strategies
techniques
grafting,
including
chemical
modification,
enzymatic
physical
elaborated.
The
properties
grafted
CH/COS,
such
solubility,
were
reported.
Additionally,
review
detailed
applications
small
molecule,
proteins,
RNA
interference
therapeutics.
Furthermore,
effectiveness
improving
pharmacokinetics
pharmacodynamics
drugs
was
included.
Finally,
challenges
limitations
associated
with
use
outline
directions
future
research
addressed.
insights
provided
will
be
valuable
researchers
development
professionals
interested
application
ACS Biomaterials Science & Engineering,
Journal Year:
2023,
Volume and Issue:
9(6), P. 3084 - 3115
Published: May 13, 2023
Over
the
past
decade,
smart
and
functional
biomaterials
have
escalated
as
one
of
most
rapidly
emerging
fields
in
life
sciences
because
performance
could
be
improved
by
careful
consideration
their
interaction
response
with
living
systems.
Thus,
chitosan
play
a
crucial
role
this
frontier
field
it
possesses
many
beneficial
properties,
especially
biomedical
such
excellent
biodegradability,
hemostatic
antibacterial
activity,
antioxidant
biocompatibility,
low
toxicity.
Furthermore,
is
versatile
biopolymer
due
to
its
polycationic
nature
reactive
groups
that
allow
polymer
form
interesting
structures
or
modified
various
ways
suit
targeted
applications.
In
review,
we
provide
an
up-to-date
development
chitosan-based
nanoparticles,
hydrogels,
nanofibers,
films,
well
application
field.
This
review
also
highlights
several
strategies
enhance
biomaterial
for
fast
growing
applications
drug
delivery
systems,
bone
scaffolds,
wound
healing,
dentistry.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
31, P. 206 - 230
Published: Aug. 14, 2023
Traditional
cancer
therapy
methods,
especially
those
directed
against
specific
intracellular
targets
or
signaling
pathways,
are
not
powerful
enough
to
overcome
tumor
heterogeneity
and
therapeutic
resistance.
Oncolytic
peptides
that
can
induce
membrane
lysis-mediated
cell
death
subsequent
anticancer
immune
responses,
has
provided
a
new
paradigm
for
therapy.
However,
the
clinical
application
of
oncolytic
is
always
limited
by
some
factors
such
as
unsatisfactory
bio-distribution,
poor
stability,
off-target
toxicity.
To
these
limitations,
polymers
stand
out
prospective
materials
owing
their
high
chemical
versatility,
scalable
production
capacity,
which
potential
drive
revolution
in
treatment.
This
review
provides
an
overview
mechanism
structure-activity
relationship
peptides.
Then
peptides-mediated
combination
nano-delivery
strategies
summarized.
Emphatically,
current
research
progress
been
highlighted.
Lastly,
challenges
prospects
development
discussed.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(20), P. 19753 - 19766
Published: Oct. 9, 2023
Synergistic
therapy
strategy
and
prognostic
monitoring
of
glioblastoma's
immune
response
to
treatment
are
crucial
optimize
patient
care
advance
clinical
outcomes.
However,
current
systemic
temozolomide
(TMZ)
chemotherapy
imaging
methods
for
in
vivo
tracing
responses
inadequate.
Herein,
we
report
an
all-in-one
theranostic
nanoprobe
(PEG/αCD25-Cy7/TMZ)
precise
real-time
glioblastoma
by
photoacoustic-fluorescence
imaging.
The
was
loaded
with
TMZ
targeted
regulatory
T
lymphocyte
optical
dye
αCD25-Cy7
encapsulated
glutathione-responsive
DSPE-SS-PEG2000.
results
showed
that
the
efficiency
lymphocytes
is
up
92.3%.
activation
PEG/αCD25-Cy7/TMZ
glutathione
enhanced
delivery
tumor
microenvironment
local
monitored
boundary
Immunotherapy
indoleamine
2,3-dioxygenase
inhibitors
after
could
promote
immunological
reduce
infiltration,
which
improve
survival
rate.
Photoacoustic
has
noninvasively
depicted
dynamic
process
on
a
micrometer
scale,
showing
infiltration
up-regulated
would
down-regulate
IDO
inhibitor
treatment.
This
promising
method
precisely
delivering
long-term
dynamically
evaluate
situ
accurate
chemo-immunotherapy.
