Light-Triggered Nanozymes Remodel the Tumor Hypoxic and Immunosuppressive Microenvironment for Ferroptosis-Enhanced Antitumor Immunity

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12261 - 12275

Published: April 29, 2024

Cancer immunotherapy holds significant promise for addressing diverse malignancies. Nevertheless, its efficacy remains constrained by the intricate tumor immunosuppressive microenvironment. Herein, a light-triggered nanozyme Fe-TCPP-R848-PEG (Fe-MOF-RP) was designed remodeling The Fe-TCPP-MOFs were utilized not only as core catalysis component against destruction but also biocompatible delivery vector of an immunologic agonist, improving long circulation and enrichment. Concurrently, it catalyzes decomposition H2O2 within tumor, yielding oxygen to augment photodynamic therapy. induced ferroptosis, in synergy with therapy, prompts liberation tumor-associated antigens from cells inducing immunogenic cell death. Phototriggered on-demand release R848 agonists stimulated maturation dendritic reverted tumor-promoting M2 phenotypes into adoptive M1 macrophages, which further reshaped Notably, effectively restrains well-established tumors, such B16F10 melanoma. Moreover, demonstrates distal tumor-inhibiting effect upon situ light treatment. What is more, lung metastasis model, elicits robust immune memory, conferring enduring protection rechallenge. Our study presents straightforward broadly applicable strategy crafting nanozymes potential thwart cancer recurrence metastasis.

Language: Английский

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Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Language: Английский

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PdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 3, 2025

An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation. Through facilitating electron transfer enhancing active sites, enhanced peroxidase-like (POD-like) enzymatic activity glutathione (GSH) depletion abilities are boosted through a simple co-reduction process, leading promising anti-tumor activity. The between Pd Ru contributes POD-like Then, by oxidizing endogenous overexpressed GSH, cycling prevents GSH consuming ROS. Furthermore, surface plasmon resonance effect on ensures its photothermal performance local heating, further promoting integrated multi-modal approach has demonstrated significant anti-cancer effects vivo studies. exhibit high catalytic efficiency excellent offering valuable insights for development nano-catalysts/enzymes biomedical applications.

Language: Английский

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Immune cell targeting-mediated cytomimetic drug delivery system for BBB-penetrating and precise therapy of in situ glioma

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101694 - 101694

Published: March 1, 2025

Language: Английский

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Stimuli-Responsive Polymeric Nanocarriers Accelerate On-Demand Drug Release to Combat Glioblastoma

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Glioblastoma multiforme (GBM) is a highly malignant brain tumor with poor prognosis and limited treatment options. Drug delivery by stimuli-responsive nanocarriers holds great promise for improving the modalities of GBM. At beginning review, we highlighted stimuli-active polymeric carrying therapies that potentially boost anti-GBM responses employing endogenous (pH, redox, hypoxia, enzyme) or exogenous stimuli (light, ultrasonic, magnetic, temperature, radiation) as triggers controlled drug release mainly via hydrophobic/hydrophilic transition, degradability, ionizability, etc. Modifying these target ligands further enhanced their capacity to traverse blood-brain barrier (BBB) preferentially accumulate in glioma cells. These unique features lead more effective cancer minimal adverse reactions superior therapeutic outcomes. Finally, review summarizes existing difficulties future prospects treating Overall, this offers theoretical guidelines developing intelligent versatile facilitate precise GBM clinical settings.

Language: Английский

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Tumor-specific enhanced NIR-II photoacoustic imaging via photothermal and low-pH coactivated AuNR@PNIPAM-VAA nanogel

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 10, 2024

Abstract Background Properly designed second near-infrared (NIR-II) nanoplatform that is responsive tumor microenvironment can intelligently distinguish between normal and cancerous tissues to achieve better targeting efficiency. Conventional photoacoustic nanoprobes are always “on”, microenvironment-responsive nanoprobe minimize the influence of endogenous chromophore background signals. Therefore, development respond internal external stimulus shows great application potential for diagnosis tumor. Results In this work, a low-pH-triggered thermal-responsive volume phase transition nanogel gold nanorod@poly(n-isopropylacrylamide)-vinyl acetic acid (AuNR@PNIPAM-VAA) was constructed detection Via an photothermal switch, absorption AuNR@PNIPAM-VAA in be dynamically regulated, so produces switchable signals NIR-II window tumor-specific enhanced imaging. vitro results show at pH 5.8, signal amplitude increases up obviously after modulating, while they remain slightly change 7.4. Quantitative calculation presents 1064 nm has ~ 1.6 folds enhancement as temperature from 37.5 °C 45 simulative microenvironment. vivo prepared imaging selective through responding thermal field, which precisely controlled by light. Conclusions This work will offer viable strategy using NIR light regulate field target low microenvironment, expected realize accurate dynamic monitoring treatment.

Language: Английский

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Glioma lateralization: Focus on the anatomical localization and the distribution of molecular alterations (Review)

Oncology Reports, Journal Year: 2024, Volume and Issue: 52(4)

Published: Aug. 16, 2024

It is well known how the precise localization of glioblastoma multiforme (GBM) predicts direction tumor spread in surrounding neuronal structures. The aim present review to reveal lateralization GBM by evaluating anatomical regions where it frequently located as main molecular alterations observed different brain regions. According literature, or most frequent has yet be determined. However, can said that more frontal lobe. Tractus and fascicles involved appear focused on corticospinal tract, superior longitudinal I, II III fascicles, arcuate fascicle long segment, strait inferior fronto‑occipital fasciculus. Considering features its involvement, logical are frontal‑temporal‑parietal‑occipital lobes, respectively. Although volumes higher right hemisphere, been determined prognosis patients diagnosed with cancer left hemisphere worse, probably reflecting distribution some detrimental such TP53 mutations, PTEN loss, EGFR amplification, MGMT promoter methylation. There theories stating less exposed external influences development responsible for functions necessary survival while tumors may aggressive. To shed light specific regions, article aimed at describing pathways gene mutations epigenetic modifications associated tumors.

Language: Английский

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In vivo visualization of tumor-associated macrophages re-education by photoacoustic/fluorescence dual-modal imaging with a metal-organic frames-based caspase-1 nanoreporter

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 659, P. 48 - 59

Published: Dec. 21, 2023

Language: Английский

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Precise Identification of Glioblastoma Micro‐Infiltration at Cellular Resolution by Raman Spectroscopy

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Precise identification of glioblastoma (GBM) microinfiltration, which is essential for achieving complete resection, remains an enormous challenge in clinical practice. Here, the study demonstrates that Raman spectroscopy effectively identifies GBM microinfiltration with cellular resolution specimens. The spectral differences between infiltrative lesions and normal brain tissues are attributed to phospholipids, nucleic acids, amino unsaturated fatty acids. These biochemical metabolites identified by further confirmed spatial metabolomics. Based on differential spectra, imaging resolves important morphological information relevant a label-free manner. area under receiver operating characteristic curve (AUC) combined machine learning detecting exceeds 95%. Most importantly, cancer cell threshold as low 3 human cells per 0.01 mm

Language: Английский

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Recent Advances in Silica-Based Nanomaterials for Enhanced Tumor Imaging and Therapy

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7133 - 7169

Published: Nov. 4, 2024

Cancer remains a formidable challenge, inflicting profound physical, psychological, and financial burdens on patients. In this context, silica-based nanomaterials have garnered significant attention for their potential in tumor imaging therapy owing to exceptional properties, such as biocompatibility, customizable porosity, versatile functionalization capabilities. This review meticulously examines the latest advancements application of therapy. It underscores enhancing various cancer modalities, including fluorescence imaging, magnetic resonance computed tomography, positron emission ultrasound multimodal approaches. Moreover, delves into therapeutic efficacy chemotherapy, radiotherapy, phototherapy, immunotherapy, gas therapy, sonodynamic chemodynamic starvation gene Critical evaluations biosafety profiles degradation pathways these within biological environments are also presented. By discussing current challenges prospects, aims provide nuanced perspective clinical translation nanomaterials, thereby highlighting promise revolutionizing diagnostics, enabling real-time monitoring responses, advancing personalized medicine.

Language: Английский

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