Next-Generation Pharmaceuticals: The Rise of Orodispersible Formulation Technology for Male Sexual Health DOI Open Access
Emmanuele A. Jannini,

Shivani Ohri Vignesh,

Tarek A. Hassan

et al.

Published: July 29, 2024

Abstract: Orodispersible film (ODF) is one of the novel formulations that have been currently made available disintegrates rapidly in mouth without requisite for water and offer several benefits over conventional oral solid dosage formulations. This delivery system serves as a discreet convenient mode administration, especially patients who dysphagia, fluid restriction, being beneficial to pediatric, geriatric, bedridden patients. A sildenafil ODF containing citrate formulated be used with erectile dysfunction (ED). review discusses advantages improving compliance satisfaction these describes bioequivalence stability studies ODF. formulation offers unique benefit ED by their acceptance, compliance, respecting privacy. Moreover, comparison pharmacokinetic parameters between administered film-coated tablet were similar. It also demonstrated reliable performance yielded consistent product, meeting all specifications at release after three weeks storage under stressed conditions (60oC). Sildenafil warrants improved ease intake, taste, portability, storage, among patients, making it potential most preferred drug choice.

Language: Английский

Next-generation pharmaceuticals: the rise of sildenafil citrate ODF for the treatment of men with erectile dysfunction DOI Creative Commons
Emmanuele A. Jannini,

Shivani Ohri Vignesh,

Tarek A. Hassan

et al.

Therapeutic Delivery, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Jan. 12, 2025

Orodispersible film (ODF) is one of the novel formulations that disintegrate rapidly in mouth without requisite for water compared to other conventional oral solid dosage formulations. This delivery system serves as a convenient mode administration, especially patients who have dysphagia and fluid restriction, being beneficial pediatric, geriatric, bedridden patients. A sildenafil ODF containing citrate formulated be used with erectile dysfunction (ED). review discusses advantages improving compliance satisfaction these describes manufacturing techniques, evaluation tests, bioequivalence, stability studies ODF. formulation offers unique benefit ED by their acceptance respecting privacy need discreet treatment. Moreover, comparison pharmacokinetic parameters between administered film-coated tablet were similar. It also demonstrated reliable performance yielded consistent product, meeting all specifications at release after three weeks storage under stressed conditions (60°C). Sildenafil warrants improved ease intake, taste, portability, storage, among patients, making it potential most preferred drug choice.

Language: Английский

Citations

1
Depression and risk of sarcopenia: a national cohort and Mendelian randomization study DOI Creative Commons
Qian Zhong, Lisha Jiang, An Kang

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 18, 2023

Background Depression and the increased risk of sarcopenia are prevalent among elderly population. However, causal associations between these factors remain unclear. To investigate potential association depression in older adults, this study was performed. Methods In baseline survey, a total 14,258 individuals aged 40 above from China Health Retirement Longitudinal Study (2015) participated. We initially described prevalence disease. Then, logistic regression restricted cubic spline (RCS) were conducted to assess relationship sarcopenia. Subgroup analysis performed validate robustness findings. Additionally, we Mendelian randomization using inverse variance weighting estimator Furthermore, adopted six methods, including MR-Egger, simple median, weighted maximum likelihood, robust adjusted profile score (RAPS), MR Pleiotropy Residual Sum Outlier (MR-PRESSO), for sensitivity analyses. Results patients exhibited higher risks all five models adjusting different covariates ( P < 0.05). The RCS demonstrated linear subgroup analysis, observed participants 60−70, married or cohabiting individuals, non-smokers, non-drinkers, those with less than 8 h sleep, BMI below 24, hypertension (all results revealed that genetically proxied led reduction appendicular skeletal muscle mass Conclusion Our provides observational evidences can lead This finding emphasizes importance timely identification management depression, as well implementing targeted educational programs part comprehensive strategies prevent

Language: Английский

Citations

16
Causal effects of gut microbiota on renal tumor: a Mendelian randomization study DOI Creative Commons
Fuxun Zhang, Yang Xiong, Bo Zhang

et al.

International Journal of Surgery, Journal Year: 2024, Volume and Issue: 110(3), P. 1870 - 1872

Published: Jan. 15, 2024

aDepartment of Urology, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China bDepartment Institute West Sichuan Chengdu, Sichuan, Fuxun Zhang and Yang Xiong contributed equally to this work. Sponsorships or competing interests that may be relevant content are disclosed at the end article. *Corresponding author. Address: Department China. E-mail address: [email protected] (B. Zhang). Supplemental Digital Content is available for Direct URL citations provided in HTML PDF versions article on journal's website, www.lww.com/international-journal-of-surgery. Published online ■ This an open access distributed under terms Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it permissible download share work properly cited. The cannot changed any way used commercially without permission from journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

Language: Английский

Citations

5
Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization DOI Creative Commons
Dongze Liu, Qin Zheng, Bocun Yi

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 12, 2024

Objectives Inflammatory cytokines (ICs) play an important role in erectile dysfunction (ED). Previous studies have demonstrated that most ED patients high levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). The causality between 41 ICs is investigated using the Mendelian randomization (MR) approach. Methods Single nucleotide polymorphisms (SNPs) exposure data came from a genome-wide association study (GWAS) 8293 subjects. At same time, FINNGEN R9 database provided outcome containing 2205 164104 controls. MR-Egger (ME), inverse variance weighting (IVW), weighted median (WM) were applied to conduct MR IVW was taken as main criterion. Results From genetic perspective, increase interferon-inducible protein-10 (IP-10) level significantly increased risk (P=0.043, odds ratio (OR)=1.269, 95% confidence interval (95%CI): 1.007-1.600), while interleukin-1 receptor antagonist (IL-1RA) markedly decreased (P=0.037, OR=0.768, 95%CI: 0.600-0.984). Meanwhile, IP-10 (p=0.099) IL-1RA (p=0.135) failed demonstrate reverse analysis. Conclusions Changes will affect ED, especially component for protective ED. In future, we can achieve targeted treatment prevention by intervening with specific inflammatory factors.

Language: Английский

Citations

5
Plasma proteome analysis implicates novel proteins as potential therapeutic targets for chronic kidney disease: A proteome-wide association study DOI Creative Commons
Yang Xiong, Tianhong Wang, Wei Wang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31704 - e31704

Published: May 22, 2024

Chronic kidney disease (CKD) is prevalent globally with limited therapeutic drugs available. To systemically identify novel proteins involved in the pathogenesis of CKD and possible targets, we integrated human plasma proteomes genome-wide association studies (GWASs) CKD, estimated glomerular filtration rate (eGFR) blood urea nitrogen (BUN) to perform proteome-wide study (PWAS), Mendelian Randomization Bayesian colocalization analyses. The single-cell RNA sequencing data healthy mouse kidneys were analyzed explore cell-type specificity identified genes. Functional enrichment analysis was conducted investigate signaling pathways. PWAS 22 significantly associated CKD. Of them, significant associations three (INHBC, LMAN2, SNUPN) replicated GWASs eGFR, BUN. analyses showed that INHBC SNUPN causally shared causal variants for BUN (all PP4 > 0.75). revealed gene sparsely scattered within cells. This proteomic INHBC, may be which represent targets warrant further exploration future research.

Language: Английский

Citations

4
The causal effect of matrix metalloproteinase-3 on ankylosing spondylitis: Evidence from Mendelian randomization DOI Creative Commons
Wen-bin LIU,

Licheng Guo,

Yongfa Zhang

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(5), P. e41373 - e41373

Published: Jan. 31, 2025

Previous investigations through observation have found that matrix metalloproteinase-3 (MMP-3) has benefits for ankylosing spondylitis (AS) but it is uncertain whether there a true positive causal connection. Our goal was to demonstrate the relationship between AS and MMP-3. We executed Mendelian randomization (MR) research utilizing genome-wide association studies genetic data (n = 21,758) MMP-3 publicly available from IEU Open 297,932) FinnGen Biobank. The specific MR protocols were weighted median, mode, MR-Egger, inverse-variance (IVW). Subsequently, Cochran Q evaluate, pleiotropy residual sum outlier, MR-Egger intercept used evaluate heterogeneity multiplicative effects of instrumental variables. IVW method demonstrated had effect on (odds ratio, 0.9047 [95% confidence interval, 0.8080-1.0129]; P .0823). Certainly, other techniques in accordance with tendency (P < .05), sensitivity testing verified reliability this result. This study substantiates role development AS, offering valuable insights into disease mechanism potential therapeutic targets.

Language: Английский

Citations

0
Identification of a circRNA-mediated immune-related ceRNA network and circRNAs as diagnostic biomarkers in acute ischemic stroke DOI Creative Commons
Hongxiang Jiang, Peidong He,

Shishi Chen

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 18, 2025

Research has demonstrated that circular RNAs (circRNAs) play important roles in acute ischemic stroke (AIS). However, the functions of circRNA-mediated competitive endogenous RNA (ceRNA) AIS-related immunological inflammation are not well understood. In our study, we aimed to construct a immune-related ceRNA network and identify diagnostic circRNAs for AIS. R software was used analyze microarray data obtained from GEO database. The bioinformatics database then develop network. A topological property study performed new circRNAs. Subsequently, validated potential both mice middle cerebral artery occlusion (MCAO) model clinical samples center with quantitative real-time polymerase chain reaction (qRT-PCR). An AIS (AISIRC) constructed, comprising genes (IRGs), circRNAs, miRNAs. subnetwork extracted AISIRC identified seven associated immune response. qRT-PCR assays were conducted validate candidate using blood MCAO mice. results circulating circOXCT1 circSLC8A1 significantly up-regulated patients. Receiver-operating characteristic (ROC) curve analyses logistic regression perfect predictive discriminative features these two biomarkers Longitudinal analysis circRNA expression after indicated promising monitoring progression dynamics. We successfully constructed (circOXCT1 circSLC8A1), which showed high sensitivity

Language: Английский

Citations

0
Concentration of Selected Serum Trace Elements in Male Patients With Diabetic Erectile Dysfunction: A Case–Control Study DOI Creative Commons
Zhe Yu, Zhenliang Pan,

R. Cai

et al.

American Journal of Men s Health, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 1, 2025

Identifying novel risk factors for erectile dysfunction (ED) is crucial developing targeted intervention. This study aimed to investigate the potential impacts of serum trace elements (TEs) concentration on diabetic ED. A retrospective case–control was conducted involving 51 patients with ED and control subjects. Serum levels copper (Cu), zinc (Zn), magnesium (Mg), iron (Fe), calcium (Ca) were measured using inductively coupled plasma-mass spectrometry (ICP-MS). While most selected TEs showed no significant differences, Cu notably higher in In addition, Cu/Zn ratio (CZr) significantly elevated group compared controls (1.3 vs. 1.2 mg/L, p < .001), reflecting its relevance oxidative stress. Receiver operating characteristic curve analysis revealed that CZr exhibited better diagnostic performance than single parameter. These findings suggest disruptions homeostasis a high probability Further studies are warranted validate our elucidate underlying mechanisms.

Language: Английский

Citations

0
Reversal of anxiety-like depression induced by chronic corticosterone by crocin I and surface-enhanced Raman spectroscopy monitoring of plasma metabolites DOI Creative Commons
Dandan Zhang,

Zhaohua Wu,

Doudou Yang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 27, 2025

Anxiety disorders and depression often co-occur lack broadly available treatments. Gardenia extract significantly associated with treatment of anxiety-like depression. Based on the dose effect hypothesis previous studies, it is speculated that crocin I, main component gardenia, related to The present study aimed verify reversal I chronic corticosterone-induced depression, further explore its metabolic process in vivo. Ultimately, a new method for rapid sensitive detection trace substances was established. In this study, rat model induced by corticosterone. effects were explored combining behavioral, pathological sections ELASA data. It first time can reverse morphological changes hippocampus corticosterone rats. terms behavior, Ⅰ improve depressive behavior exhibited rats water maze sugar preference experiments. also repair neuronal cell damage Dentate gyrus, CA1, CA3 areas hippocampus. regulates expression levels monoamine neurotransmitters brain, thereby exerting an anti-anxiety-like effect. Pharmacokinetic analysis performed determine Further integrating Surface-Enhanced Raman Scattering (SERS) technology, highly had been discovered hippocampal morphology caused determined exert therapeutic regulating brain. vivo pharmacokinetic experiments revealed could not pass through intestinal barrier into blood, but metabolite crocetin blood. Finally, synthesizing silver nanoparticles, amounts blood samples established time.The calculated enhancement factor 4.49 × 1011. stable reproducible over week. This series studies great potential treating comorbid anxiety shortens distance from theoretical research clinical application.

Language: Английский

Citations

0
Association between C-reactive protein-triglyceride glucose index and testosterone levels among adult men: analyses of NHANES 2015–2016 data DOI Creative Commons
Bo Zhang, Yi Gu, Yiming Chen

et al.

Sexual Medicine, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 1, 2025

Language: Английский

Citations

0