Bacteria-tumor symbiosis destructible novel nanocatalysis drug delivery systems for effective tumor therapy DOI

Jing Zang,

Yin Fang, Ziyuan Liu

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 20(3), P. 305 - 318

Published: Dec. 30, 2024

Colorectal cancer (CRC) is a significant threat to human health. The dynamic equilibrium between probiotics and pathogenic bacteria within the gut microbiota crucial in mitigating risk of CRC. An overgrowth harmful microorganisms gastrointestinal tract can result an excessive accumulation bacterial toxins carcinogenic metabolites, thereby disrupting delicate balance microbiota. This disruption may lead alterations microbial composition, impairment mucosal barrier function, potential promotion abnormal cell proliferation, ultimately contribute progression Recently, research has indicated that intestinal presence Fusobacterium nucleatum (Fn) significantly influences onset, progression, metastasis Consequently, interaction CRC cells Fn presents promising strategy against Nanomaterials have been extensively utilized therapy infection control, demonstrating substantial treating bacteria-associated tumors. review begins by elucidating mechanisms occurrence CRC, with particular emphasis on clarifying intricate relationship Subsequently, we highlight strategies utilize nanomaterials disrupt association Overall, this offers valuable insight guidance for leveraging therapy.

Language: Английский

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

Citations

16
Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

Citations

3
Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives DOI
Jiyuan Liu, Fan Yang, Jinqu Hu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Language: Английский

Citations

11
Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases DOI Creative Commons

Eman K. E. Anwer,

Muhammad Ajagbe,

Mohamed Sherif

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 100 - 100

Published: Jan. 3, 2025

The gut microbiota, a dynamic ecosystem of trillions microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role these metabolites, particularly short-chain fatty acids, indoles, and bile in modulating immune responses, impacting epigenetic mechanisms, contributing to disease processes. In gastrointestinal (GI) cancers such as colorectal, liver, gastric cancer, microbial can drive tumorigenesis by promoting inflammation, DNA damage, evasion. Conversely, same hold therapeutic promise, potentially enhancing responses chemotherapy immunotherapy even directly suppressing tumor growth. addition, play crucial roles infectious susceptibility resilience, mediating pathways impact pathogen resistance. By consolidating recent insights into microbiota's shaping health, this review underscores potential targeting microbiome-derived for treating GI diseases calls further microbiome-based interventions.

Language: Английский

Citations

1
Synergistic Interactions Between Probiotics and Anticancer Drugs: Mechanisms, Benefits, and Challenges DOI
Babak Pezeshki, Hussein T. Abdulabbas, Asma M. Alturki

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

1
Akkermansia muciniphila-derived pentadecanoic acid enhances oxaliplatin sensitivity in gastric cancer by modulating glycolysis DOI Creative Commons
Qixuan Xu, Jingwang Gao, Ruiyang Zhao

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107278 - 107278

Published: June 20, 2024

Accumulating evidence has proved the close association between alterations in gut microbiota and resistance to chemotherapeutic drugs. However, potential roles of regulating oxaliplatin sensitivity gastric cancer (GC) have not been investigated before. We first found that antibiotic treatment diminished therapeutic efficacy a GC mouse model. Importantly, this effect could be transmitted germ-free mice via fecal transplantation, indicating role modulation efficacy. Further, metagenomics data showed Akkermansia muciniphila (A. muciniphila) ranked among bacterial species with decreased relative abundances after treatment. Metabolically active A. promotes As shown by metabolomics analysis, metabolic pattern was disrupted significantly downregulated levels pentadecanoic acid (PEA), use PEA promoted Mechanistically, FUBP1 positively regulated aerobic glycolysis cells hinder oxaliplatin. muciniphila-derived functioned as an inhibitory factor directly antagonizing activity FUBP1, which potentiated responses Our research suggested key for intestinal its metabolite promoting efficacy, thus providing new perspective probiotic prebiotic intervention patients during chemotherapy.

Language: Английский

Citations

7
Gut microbiota interact with breast cancer therapeutics to modulate efficacy DOI Creative Commons
Alana A. Arnone,

Katherine Ansley,

Arielle L. Heeke

et al.

EMBO Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Abstract The gut microbiome, or the community of microorganisms residing in gastrointestinal tract, has emerged as an important factor breast cancer etiology and treatment. Specifically, impact bacterial populations on therapeutic outcomes is emerging area research. microbiota’s role modifying pharmacokinetics chemotherapy endocrine-targeting therapies can alter drug efficacy toxicity profiles. In addition, microbiome’s capacity to regulate systemic inflammation immune responses may influence effectiveness both conventional immunotherapeutic strategies for treatment cancer. Overall, while bidirectional interactions between microbiome are still being studied, its increasingly recognized. Future research provide more definitive insights help develop personalized harness improve outcomes.

Language: Английский

Citations

0
Dermatologic toxicities related to cancer immunotherapy DOI Creative Commons
Yosra Vaez-Gharamaleki, Mohammad Amin Akbarzadeh, Farhad Jadidi‐Niaragh

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102021 - 102021

Published: April 1, 2025

Language: Английский

Citations

0
Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions DOI
Naveen Jeyaraman,

Madhan Jeyaraman,

Priya Dhanpal

et al.

World Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 11, 2025

The gut microbiome, a complex ecosystem of microorganisms, has significant role in modulating pain, particularly within orthopaedic conditions. Its impact on immune and neurological functions is underscored by the gut-brain axis, which influences inflammation, pain perception, systemic responses. This integrative review examines current research how dysbiosis associated with various pathways, notably nociceptive neuroinflammatory mechanisms linked to central sensitization. We highlight advancements meta-omics technologies, such as metagenomics metaproteomics, deepen our understanding microbiome-host interactions their implications pain. Recent studies emphasize that gut-derived short-chain fatty acids microbial metabolites play roles neuroinflammation nociception, contributing management. Probiotics, prebiotics, synbiotics, faecal microbiome transplants are explored potential therapeutic strategies alleviate through modulation, offering an adjunct or alternative opioids. However, variability individual microbiomes poses challenges standardizing these treatments, necessitating further rigorous clinical trials. A multidisciplinary approach combining microbiology, immunology, neurology, orthopaedics essential develop innovative, personalized management rooted health, transform care.

Language: Английский

Citations

0
Exploring the role of oral bacteria in oral cancer: a narrative review DOI Creative Commons

Hassan Mivehchi,

Aisan Eskandari-Yaghbastlo,

Parnian Pour Bahrami

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 26, 2025

A growing body of research indicates that a wide range cancer types may correlate with human microbiome components. On the other hand, little is known about potential contribution oral microbiota to cancer. However, some components can stimulate different tumorigenic processes associated development In this line, two prevalent infections, Porphyromonas gingivalis, and Fusobacterium nucleatum increase tumor growth. The impact course illness through direct interactions major modifications toxicity responsiveness kinds therapy. Recent has demonstrated relationship between specific phylogenetic groupings results immunotherapy treatment for particular types. Conversely, there been recent upsurge in interest possibility using microbes treat At moment, species, such as Salmonella typhimurium Clostridium spp., are being explored possible vectors. Thus, understanding these microbial highlights importance maintaining healthy preventing cancers. From perspective, review will discuss role on cancers their application treatment/improvement.

Language: Английский

Citations

0