Journal of Bioscience and Bioengineering, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Vision, Journal Year: 2025, Volume and Issue: 9(2), P. 35 - 35
Published: April 17, 2025
Retina, a light-sensitive layer of tissue the eye, requires high levels oxygen for its physiology. Retinal ischemia occurs due to inadequate supply blood retina and choroid. is implicated in development or progression many ocular diseases, such as diabetic retinopathy (DR) age-related macular degeneration (AMD). To date, anti-vascular endothelial growth factor (VEGF) treatment has been widely used manage neovascular diseases associated with retinal ischemia. Nonetheless, substantial number patients DR AMD still suffer from incomplete response adverse effects related therapy limitations. Therefore, research scientists have developing finding novel treatments protect against prevent vision loss those diseases. In this review article, we summarize recent therapeutic approaches ischemic (e.g., cell therapy, advanced molecular targeting, drug delivery). This summary enables further obtain more solid evidence effective
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 26, 2025
Abstract Organoids provide 3D structures that replicate native tissues in biomedical research. The development of vascular networks within organoids enables oxygen and nutrient delivery while facilitating metabolic waste removal, which supports organoid growth maturation. Recent studies demonstrate vascularized models offer insights into tissue interactions promote regeneration. However, the current limitations establishing functional affect growth, viability, clinical translation potential. This review examines organoids, including mechanisms angiogenesis vasculogenesis, construction strategies, applications. approaches are categorized vivo vitro methods, with analysis their specific advantages limitations. also discusses emerging techniques such as bioprinting gene editing for improving vascularization integration organoid‐based therapies. Current developments indicate potential applications modeling human diseases developing therapeutic contributing to advances translational
Language: Английский
Citations
0
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 537 - 537
Published: April 27, 2024
The paracrine signaling pathways for the crosstalk between pericytes and endothelial cells are essential coordination of cell responses to challenges such as hypoxia in both healthy individuals pathological conditions. Ischemia-reperfusion injury (IRI), one causes cellular dysfunction death, is associated with increased expression genes involved adaptation a hypoxic environment. Hypoxic inducible factors (HIFs) have central role response processes initiated by IRI not only linked erythropoietin production but also because their participation inflammation, angiogenesis, metabolic adaptation, fibrosis. While an physiological function production, lesser-known HIF stabilization during that pericytes' could influence vascular remodeling, loss organ Better knowledge mechanisms control functions consequences beyond advisable development therapeutic strategies disease progression improve treatments. Thus, this review, we discuss dual roles-for good or bad-of IRI, focusing on pericytes, particular kidneys.
Language: Английский
Citations
3
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 135, P. 112290 - 112290
Published: May 25, 2024
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6592 - 6592
Published: June 15, 2024
Pericytes are multipotent cells embedded within the vascular system, primarily surrounding capillaries and microvessels where they closely interact with endothelial cells. These known for their intriguing properties due to heterogeneity in tissue distribution, origin, multifunctional capabilities. Specifically, pericytes essential regulating blood flow, promoting angiogenesis, supporting homeostasis regeneration. multifaceted roles draw on pericytes’ remarkable ability respond biochemical cues, neighboring cells, adapt changing environmental conditions. This review aims summarize existing knowledge pericytes, emphasizing versatility involvement integrity health. In particular, a comprehensive view of major signaling pathways, such as PDGFβ/ PDGFRβ, TGF-β, FOXO VEGF, along downstream targets, which coordinate behavior preserving regeneration, will be discussed. this light, deeper understanding complex networks defining phenotype healthy tissues is crucial development targeted therapies degenerative diseases.
Language: Английский
Citations
3
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 7, 2024
Abstract The current challenge in analyzing sequencing-based spatial transcriptomics (ST) is to precisely resolve the distribution of cell subpopulations with low abundance and detect context-dependent variation states within complex tissue microenvironments. Here, we introduce an ultra-resolution ST deconvolution algorithm (UCASpatial) that improves resolution mapping locations by leveraging contribution genes indicative identity through entropy-based weighting. Using both silico real datasets, demonstrate UCASpatial robustness accuracy identifying low-abundant distinguishing transcriptionally heterogeneous subpopulations. Applying murine wound healing, recapitulate known spatiotemporal dynamics multiple involved healing reveal segregation distinct macrophage embedded different cellular communities at center. In human colorectal cancer (CRC), link genomic alterations individual clones multi-cellular characteristics tumor immune microenvironment (TIME) co-evolution cells TIME same tumor. We show copy number gain on chromosome 20q (chr20q-gain) orchestrates a T cell-excluded TIME, resistance immunotherapy CRC, associated tumor-intrinsic endogenous retrovirus silencing impaired type I interferon response. Our findings present as versatile tool for deciphering landscapes exploring intercellular mechanisms dynamic
Language: Английский
Citations
1
Placenta, Journal Year: 2024, Volume and Issue: 155, P. 1 - 10
Published: Aug. 2, 2024
Pericytes wrap microvessels and interact with endothelial cells to regulate vascular growth. Though pericyte dropout has been reported in pathological human placentae mouse models of placental pathology, there limited investigation the role function pericytes health pathology. This study aimed investigate angiogenic potential relative other villous cell populations.
Language: Английский
Citations
0
Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1510 - 1510
Published: Sept. 9, 2024
Pericytes are versatile cells integral to the blood vessel walls of microcirculation, where they exhibit specific stem cell traits. They essential in modulating flow, ensuring vascular permeability, and maintaining homeostasis involved tissue repair process. The human endometrium is a unique complex that serves as natural scar-free healing model with its cyclical regeneration process every month. regulation pericytes has gained increasing attention due their involvement various physiological pathological processes. However, endometrial less well studied compared other organs. This review aims provide comprehensive overview pericytes, focus on elucidating function potential implications uterine disorders.
Language: Английский
Citations
0
Journal of Molecular Recognition, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 10, 2024
Due to its intricate molecular and structural characteristics, vascular endothelial growth factor receptor 2 (VEGFR-2) is essential for the development of new blood vessels in various pathological processes conditions, especially cancers. VEGFR-2 inhibitors have demonstrated significant anticancer effects by blocking many signaling pathways linked tumor growth, metastasis, angiogenesis. Several small compounds, including well-tolerated sunitinib sorafenib, been approved as inhibitors. However, widespread side these inhibitors-hypertension, epistaxis, proteinuria, upper respiratory infection-motivate researchers search with better pharmacokinetic profiles. The key interactions required interaction molecules protein target produce desired pharmacological are identified using computer-aided drug design (CADD) methods such pharmacophore QSAR modeling, structure-based virtual screening, docking, dynamics (MD) simulation coupled MM/PB(GB)SA, other computational strategies. This review discusses applications inhibitor design. Future designs may be influenced this review, which focuses on current trends multiple screening layers
Language: Английский
Citations
0
Journal of Bioscience and Bioengineering, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
0