Exploring Potential Complement Modulation Strategies for Ischemia–Reperfusion Injury in Kidney Transplantation

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 66 - 66

Published: Jan. 8, 2025

The complement system plays a crucial role in regulating the inflammatory responses kidney transplantation, potentially contributing to early decline function. Ischemia-reperfusion injury (IRI) is among factors affecting graft outcomes and primary contributor delayed Complement activation, particularly alternative pathway, participates pathogenesis of IRI, involving all compartments. In particular, tubular epithelial cells often acquire dysfunctional phenotype that can exacerbate activation damage. Currently, complement-modulating drugs are under investigation for treatment diseases. Many these have shown potential therapeutic benefits, but no effective clinical treatments renal IRI been identified yet. this review, we will explore target factors, receptors, regulatory proteins, aiming highlight their value improving management IRI.

Language: Английский

Emerging Role of Hypoxia-Inducible Factors (HIFs) in Modulating Autophagy: Perspectives on Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1752 - 1752

Published: Feb. 19, 2025

Hypoxia-inducible factors (HIFs) are master regulators of cellular responses to low oxygen levels and modulate autophagy, a conserved process essential for maintaining homeostasis. Under hypoxic conditions, HIFs regulate the expression autophagy-related genes influence autophagic flux stress responses. Dysregulated hypoxia-induced autophagy promotes cancer cell survival, metabolism, metastasis, thereby contributing treatment resistance. Targeting HIF-mediated pathways or modulating processes offers potential improve traditional therapies overcome drug Pharmacological inhibitors either alone in combination with other treatments, may disrupt pro-survival mechanisms within tumor microenvironment. Further research is needed elucidate intricate interplay between HIF signaling machinery cells. Understanding these could pave way novel therapeutic strategies enhance outcomes combat This review highlights complex relationship development therapy, offering insights into how targeting patient outcomes.

Language: Английский

Mechanism of Coronary Microcirculation Obstruction after Acute Myocardial Infarction and Cardioprotective Strategies

Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(10)

Published: Oct. 12, 2024

ST-segment elevation myocardial infarction patients are best treated with emergency percutaneous coronary intervention (PCI), while microvascular dysfunction and obstruction (CMVO) indicated by the absence or slowing of antegrade epicardial flow on angiography, resulting in suboptimal perfusion despite lack mechanical vascular obstruction. CMVO occurs up to half who undergo PCI for first time is associated poor outcomes. This review summarizes complex mechanisms leading elaborates changes observed at organism, tissue, organ, cellular, molecular levels. It also describes current diagnostic methods comprehensive treatment CMVO.

Language: Английский