International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113627 - 113627
Published: Nov. 22, 2024
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 2, 2025
Language: Английский
Citations
0
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 6, 2025
Intrauterine growth restriction (IUGR) caused by placental dysfunctions leads to fetal defects. Maternal microbiome and its metabolites have been reported promote development. Milk fat globule membrane (MFGM) is known for diverse bioactive functions, while the effects of gestational MFGM supplementation on maternal gut microbiota, efficiency, development remained unclear. In this study, low protein diet-induced IUGR decreased litter birth weight, fetal/placental ratio in pregnant mice, restored these impairments. Meanwhile, during gestation enriched intestinal Lactobacillus murinus (L. murinus) increased luminal circulating short chain fatty acids (SCFAs) which improved efficiency due an enhanced antioxidant capacity a inflammation. addition, fecal microbiota transplantation (FMT) with MFGM-derived reprinted promoted phenotypes characteristics, L. enrichment, MFGM-fed were also recapitulated exogenous administration or SCFAs cocktail. Mechanically, MFGM, murinus, cocktail activated IUGR-induced depressive phosphorylation PI3K-Akt signaling placenta. Moreover, vitro cells cultivation under amino acid shortage model (AAS) oxygen-glucose (OGS) was used validate that key microbial cocktails can alleviate oxidative stress inflammation via activating PI3K/Akt signaling. Taken together, thereby improving growth, functions fetus. Our findings will provide theoretical support application maternal–placental-fetal nutrition address pregnancy malnutrition-induced IUGR.
Language: Английский
Citations
0
Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 143 - 143
Published: Jan. 30, 2025
Melatonin is indispensable for the homeostasis of plants and animals. In humans, it can help prevent or be an adjuvant treatment several diseases mainly related to immune system, inflammation, oxidative stress. Moreover, a melatonin-rich diet linked health benefits, such as regulation circadian rhythm, immunological epilepsy control, delaying aging process, diminishing hormones cancer. This review aimed show effects melatonin in beyond its traditional use. The results showed present scavenging free radicals, reducing inflammatory cytokines, modulating system. improve insulin resistance, blood pressure, LDL-c, adipose tissue mass, adhesion molecules, endothelial impairment, plaque formation. These result neuro- cardioprotection, improvement liver diseases, rheumatoid arthritis, dermatitis, COVID-19, polycystic ovaries, sepsis. We conclude that plant benefit patients with many besides sleep problems neurodegeneration. Plant may more cost-effective fewer adverse events than synthetic. However, clinical trials should performed adequate doses, formulation, time.
Language: Английский
Citations
0
Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: July 4, 2024
Intrauterine growth restriction (IUGR) or intrauterine retardation is a condition that the fetus does not grow as expected. And biometric profile match with age of fetus. This associated increased mortality and morbidity neonates along risk cardiovascular, lung, central nervous system damage. Despite close monitoring high-risk mothers development new therapeutic approaches, optimal outcome has been achieved yet it indicates importance investigations on approaches. Melatonin (MLT) neurohormone mainly produced by pineal gland wide range effects different organs due to broad dispersion its receptors. Moreover, melatonin placenta also receptors have found surface this organ. Not only studies showed but they proved highly anti-oxidant properties. As in IUGR oxidative stress inflammation could counteract these changes improved organ's function. In study, we use MLT be good clinical approach for treatment high activity vasodilation dampen mechanisms lead development.
Language: Английский
Citations
1
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118571 - 118571
Published: Nov. 1, 2024
Language: Английский
Citations
1
Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107290 - 107290
Published: July 1, 2024
The placenta, as a "transit station" between mother and fetus, has functions delivering nutrients, excreting metabolic wastes secreting hormones. A healthy placenta is essential for fetal growth development while the melatonergic system seems to play critical physiological role in this organ since melatonin, its synthetic enzymes receptors are present placenta. In current study, Mtnr1a Mtnr1b knockout mice were constructed explore potential roles of played on placental function intrauterine retardation (IUGR). result showed that had little effect reduced efficiency increased IUGR. Considering extremely high incidence IURG sows, pregnant sows treated with melatonin. This treatment All evidence suggests intact required function. Mechanistical studies uncovered oxidative stress apoptosis but angiogenesis. RNA sequencing combined histochemistry study identified angiogenesis vascular density mice. These alterations mediated by disrupted STAT3/VEGFR2/PI3K/AKT pathway, i.e., phosphorylation STAT3 which promotor VEGFR2. downregulated VEGFR2 downstream elements PI3K AKT expressions, then, jeopardizes development.
Language: Английский
Citations
0
Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 123, P. 106586 - 106586
Published: Nov. 21, 2024
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113627 - 113627
Published: Nov. 22, 2024
Language: Английский
Citations
0