LONG-RANGE PCR AS A TOOL FOR EVALUATING MITOCHONDRIAL DNA DAMAGE: PRINCIPLES, BENEFITS, AND LIMITATIONS OF THE TECHNIQUE

DNA repair, Journal Year: 2025, Volume and Issue: 146, P. 103812 - 103812

Published: Jan. 18, 2025

Language: Английский

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The role of quercetin in NLRP3-associated inflammation

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 22, 2024

Language: Английский

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Cardamom extract alleviates tamoxifen-induced liver damage by suppressing inflammation and pyroptosis pathway

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 8, 2025

Tamoxifen (TAM) is extensively used to manage estrogen receptor-positive breast cancer. Despite its effectiveness, administration can negatively impact various organs, including the liver. This research focused on effects of TAM pyroptotic pathway in liver and evaluated potential cardamom extract (CRDE) lessen hepatic damage female rats. Rats received 45 mg/kg injections for 10 days, while groups treated with CRDE 12 ml/kg 20 commencing days before administration. exposure resulted apparent degenerations tissue inflammatory cell infiltration loss architectures. Serum levels enzymes alanine aminotransferase, aspartate aminotransferase alkaline phosphatase were elevated, along oxidative stress, as shown by increased lipid peroxidation lower reduced glutathione. caused inflammation indicated higher tumor necrosis factor-α interleukin-6 well expression CD68; a phagocytic Kupffer's cells marker. Additionally, protein analysis revealed high markers NLRP3-inflammasome, caspase-1, gasdermin D. Conversely, treatment effectively neutralized biochemical, histological, alterations induced TAM. In conclusion, demonstrated protect from TAM-induced regulating mechanisms involving damage, inflammation, pyroptosis.

Language: Английский

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Targeting Ischemia-reperfusion Injury in Liver Transplant Rejuvenation

Transplantation Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100176 - 100176

Published: Feb. 1, 2025

Language: Английский

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Prenylation of flavonoids by DMATS1 and their anti‐inflammatory activities

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract BACKGROUND Prenylated flavonoids are widely distributed in plants, including fruits and vegetables the Moraceae Fabaceae families. These chemicals potential functional food ingredients owing to their attractive biological activities. However, natural prenylated rare, which limits application. RESULTS Here, we reported prenylation of apigenin genistein catalyzed by DMATS1, a dimethylallyl‐ l ‐tryptophan synthase from Fusarium fujikuroi . High‐performance liquid chromatography–tandem mass spectrometry nuclear magnetic resonance identified structure as 6‐ C ‐prenylapigenin (6‐PA) ‐prenylgenistein (6‐PG), respectively. Cell‐based assay suggested that both 6‐PA 6‐PG induced proliferation THP‐1 cells under low concentrations were safe doses less than 50 μmol L −1 exhibited significant anti‐inflammatory activity lipopolysaccharide‐stimulated cells, inhibited production nitric oxide well downregulating transcriptional levels pro‐inflammatory cytokines, tumor necrosis factor‐α, interleukin‐8, interleukin‐1β. CONCLUSION The findings DMATS1 could catalyze genistein, generated activity, aiding recognition nutraceuticals. © 2025 Society Chemical Industry.

Language: Английский

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Preparation and evaluation of near-infrared and pH dual-responsive mesoporous carbon nanospheres for controlled drug release

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130699 - 130699

Published: March 1, 2025

Language: Английский

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Fluorinated Sulfonamide-Flavonoid Derivatives as Novel Keap1-Nrf2 Inhibitors: Potent Induction of Cytoprotective Gene HO-1 In Vivo

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117650 - 117650

Published: April 1, 2025

Language: Английский

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Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101432 - 101432

Published: Dec. 28, 2024

Flap techniques are indispensable in modern surgery because of their role repairing tissue defects and restoring function. Ischemia-reperfusion oxidative stress-induced injuries the main causes flap failure. Oxidative stress exacerbates cell damage through accumulation reactive oxygen species (ROS), thereby affecting function survival. Effective management these factors is essential for improving survival post-operative recovery. In this study, we utilized hollow mesoporous cerium dioxide nanoparticles loaded with quercetin, which were later into a light-cured double cross-linked hydrogel (HQu@BC) injected site to activate macrophage reprogramming maintain local ROS homeostasis reduce inflammation. Quercetin scavenges reduces mitochondrial due its intrinsic reducing structures such as catechols, carbon-carbon bonds, hydroxyl synergistic nanoparticles, inhibits inflammation by suppressing M1 polarization. This system continuously regulates levels, kills bacteria ultimately inflammation, creating favorable microenvironment innovative injectable composite nanoparticle material has anti-inflammatory, antioxidant, antimicrobial, healing-promoting properties, providing new approach success surgery.

Language: Английский

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Advances in cytokine-based herbal medicine against premature ovarian insufficiency: A review

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118477 - 118477

Published: June 21, 2024

Language: Английский

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Ticlopidine protects hepatic ischemia-reperfusion injury via suppressing ferroptosis

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 733, P. 150436 - 150436

Published: July 23, 2024

Language: Английский

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