How gut microbiota may impact ocular surface homeostasis and related disorders DOI Creative Commons
Marc Labétoulle, Christophe Baudouin,

José Manuel Benítez del Castillo

et al.

Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 100, P. 101250 - 101250

Published: March 8, 2024

Changes in the bacterial flora gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those an inflammatory, neuronal, psychological or hormonal factor involved pathogenesis and/or perception of disease. Maintaining ocular surface homeostasis is based on all these four factors, and there accumulating evidence literature relationship between microbiota diseases. The mechanisms mostly interconnected due interaction central peripheral neuronal networks, inflammatory effectors system. A better understanding influence maintenance homeostasis, onset persistence disorders could bring new insights help elucidate epidemiology pathology dynamics health Revealing exact nature associations paramount importance for developing a holistic approach using highly promising therapeutic strategies targeting

Language: Английский

Lupus nephritis DOI
Hans‐Joachim Anders, Ramesh Saxena, Ming‐Hui Zhao

et al.

Nature Reviews Disease Primers, Journal Year: 2020, Volume and Issue: 6(1)

Published: Jan. 23, 2020

Language: Английский

Citations

656
The impact of the gut microbiome on extra-intestinal autoimmune diseases DOI
Eiji Miyauchi, Chikako Shimokawa, Alex Steimle

et al.

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(1), P. 9 - 23

Published: May 9, 2022

Language: Английский

Citations

236
Relationships Between Vitamin D, Gut Microbiome, and Systemic Autoimmunity DOI Creative Commons
Erin Yamamoto, Trine N. Jørgensen

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 10

Published: Jan. 21, 2020

There is increasing recognition of the role microbiome plays in states health and disease. Microbiome studies systemic autoimmune diseases demonstrate unique microbial patterns Inflammatory Bowel Disease, Rheumatoid Arthritis Systemic Lupus Erythematosus to a lesser extent, whereas there no single bug or pattern that characterizes Multiple Sclerosis. Autoimmune tend share predisposition for vitamin D deficiency, which alters integrity gut epithelial barrier. In this review, we summarize influence intestinal bacteria on immune system, explore have emerged from diseases, discuss how deficiency may contribute autoimmunity via its effects barrier function, composition, and/or direct responses.

Language: Английский

Citations

200
The Gut Microbiota: Emerging Evidence in Autoimmune Diseases DOI
Xuan Zhang, Beidi Chen, Lidan Zhao

et al.

Trends in Molecular Medicine, Journal Year: 2020, Volume and Issue: 26(9), P. 862 - 873

Published: May 10, 2020

Language: Английский

Citations

177
An Autoimmunogenic and Proinflammatory Profile Defined by the Gut Microbiota of Patients With Untreated Systemic Lupus Erythematosus DOI
Beidi Chen, Xinmiao Jia,

Jia‐yue Xu

et al.

Arthritis & Rheumatology, Journal Year: 2020, Volume and Issue: 73(2), P. 232 - 243

Published: Oct. 30, 2020

Objective Changes in gut microbiota have been linked to systemic lupus erythematosus (SLE), but knowledge is limited. Our study aimed provide an in‐depth understanding of the contribution immunopathogenesis SLE. Methods Fecal metagenomes from 117 patients with untreated SLE and 52 posttreatment were aligned 115 matched healthy controls analyzed by whole‐genome profiling. For comparison, we assessed fecal metagenome MRL/ lpr mice. The oral origin species that existed was documented single‐nucleotide polymorphism–based strain‐level analyses. Functional validation assays performed demonstrate molecular mimicry newly found microbial peptides. Results Gut individuals displayed significant differences composition function compared controls. Certain species, including Clostridium ATCC BAA‐442 as well Atopobium rimae , Shuttleworthia satelles Actinomyces massiliensis Bacteroides fragilis leptum enriched reduced after treatment. Enhanced lipopolysaccharide biosynthesis branched chain amino acid observed patients. findings mice consistent our human subjects. Interestingly, some demonstrated proinflammatory capacities peptides derived SLE‐enriched species. Conclusion This provides detailed information on SLE, their functional signatures, similarities murine counterparts, origin, definition autoantigen‐mimicking data microbiome‐altering approaches may offer valuable adjuvant therapies

Language: Английский

Citations

172
Causal Effects of Gut Microbiome on Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study DOI Creative Commons
Kun Xiang, Peng Wang, Zhiwei Xu

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Sept. 7, 2021

The observational association between gut microbiome and systemic lupus erythematosus (SLE) has been well documented. However, whether the is causal remains unclear. present study used publicly available genome-wide (GWAS) summary data to perform two-sample Mendelian randomization (MR), aiming examine links SLE. Two sets of MR analyses were conducted. A group single nucleotide polymorphisms (SNPs) that less than statistical significance threshold (5 × 10-8) served as instrumental variables. To obtain a comprehensive conclusion, other where SNPs smaller locus-wide level (1 10-5) selected Based on level, results indicated there effects components SLE risk. inverse variance weighted (IVW) method suggested Bacilli Lactobacillales positively correlated with risk Bacillales, Coprobacter Lachnospira negatively median supported Bacilli, Lactobacillales, Eggerthella factors for Bacillales protective estimates Egger genetically predicted Ruminiclostridium6 was associated threshold, showed Actinobacteria might reduce pleiotropy residual sum outlier (MR-PRESSO) detected significant horizontal variables outcome. This support are beneficial or detrimental

Language: Английский

Citations

165
The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases DOI Creative Commons
Huihui Xu,

Meijie Liu,

Jinfeng Cao

et al.

Journal of Immunology Research, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 14

Published: Oct. 27, 2019

The human gut-resident commensal microbiota is a unique ecosystem associated with various bodily functions, especially immunity. Gut dysbiosis plays crucial role in autoimmune disease pathogenesis as well bowel-related diseases. However, the of gut microbiota, which causes or influences systemic immunity diseases, remains elusive. Aryl hydrocarbon receptor, ligand-activated transcription factor, master moderator host-microbiota interactions because it shapes immune system and impacts host metabolism. In addition, treatment optimization while minimizing potential adverse effects diseases essential, modulation constitutes clinical therapy. Here, we present evidence linking mechanisms involved development to identify future effective approaches based on for preventing

Language: Английский

Citations

156
Systemic Lupus Erythematosus: New Diagnostic and Therapeutic Approaches DOI Creative Commons

Stephanie Lazar,

J. Michelle Kahlenberg

Annual Review of Medicine, Journal Year: 2022, Volume and Issue: 74(1), P. 339 - 352

Published: July 9, 2022

Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that can result in substantial morbidity and mortality. Diagnosis treatment of SLE are clinical challenges. Patient presentation response to therapy heterogeneous because the complex immune dysregulation results pathogenesis. An intricate interplay between genetic risk skewing adaptive innate system responses leads overproduction type I interferons other cytokines, complement activation, immune-complex deposition, ultimately inflammation tissue damage. Here, we review classification criteria as well standard emerging diagnostic tools available identify patients with SLE. We then focus on medical management, including novel therapeutics, nonpharmacologic interventions, comorbidity management.

Language: Английский

Citations

131
Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: An EXPLORER trial DOI
Cancan Huang, Ping Yi,

Zhu Ming

et al.

Journal of Autoimmunity, Journal Year: 2022, Volume and Issue: 130, P. 102844 - 102844

Published: June 1, 2022

Language: Английский

Citations

91
Role of gut microbiota in infectious and inflammatory diseases DOI Creative Commons
Miriãn Ferrão Maciel-Fiuza,

Guilherme Cerutti Müller,

Daniel Marques Stuart Campos

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: March 27, 2023

Thousands of microorganisms compose the human gut microbiota, fighting pathogens in infectious diseases and inhibiting or inducing inflammation different immunological contexts. The microbiome is a dynamic complex ecosystem that helps proliferation, growth, differentiation epithelial immune cells to maintain intestinal homeostasis. Disorders cause alteration this microbiota lead an imbalance host's regulation. Growing evidence supports microbial community associated with development progression inflammatory diseases. Therefore, understanding interaction between modulation system fundamental mechanisms involved pathologies, as well for search new treatments. Here we review main bacteria capable impacting response pathologies discuss by which can alter disease outcomes.

Language: Английский

Citations

90