The Role of the Gut Microbiome in Immune Dysregulation and Pathogenesis of Inflammatory Bowel Disease DOI Creative Commons
Madiha Tariq,

Haleem Khan,

Maryam Gulzar

et al.

Developmental medico-life-sciences, Journal Year: 2025, Volume and Issue: 2(1), P. 13 - 25

Published: Jan. 31, 2025

Background: Inflammatory Bowel Disease (IBD), encompassing Crohn's (CD) and Ulcerative Colitis (UC), is a chronic, debilitating disorder affecting the gastrointestinal tract. The gut microbiome pivotal in maintaining intestinal homeostasis regulating immune function. Dysbiosis, or microbial imbalance, has been increasingly recognized as key factor pathogenesis of IBD, driving chronic inflammation dysregulation. Objectives: This systematic review aims to explore relationship between responses IBD. Specifically, it investigates how dysbiosis contributes disease modulation, evaluates efficacy microbiome-targeted therapies such probiotics, prebiotics, fecal microbiota transplantation (FMT). Methods: We conducted comprehensive search PubMed, Scopus, Web Science for studies published 2000 2024. Studies included randomized controlled trials, observational studies, reviews focused on alterations IBD use interventions. Quality was assessed using Cochrane Risk Bias Tool Newcastle-Ottawa Scale. Data synthesis performed narrative analysis descriptive statistics. Results: Key findings indicate that marked by reduction beneficial taxa Faecalibacterium prausnitzii Akkermansia muciniphila, alongside overgrowth pathogenic microbes like Escherichia coli (AIEC). Microbiome-targeted therapies, including FMT, showed promising results restoring balance, though variable, particularly UC CD. Conclusion: Dysbiosis central pathogenesis. offer potential but require personalized approaches improve treatment efficacy. Future research should integrate multi-omics technologies better understanding management

Language: Английский

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases DOI Open Access
Mohamed Kamel,

Sami Aleya,

Majed Alsubih

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 217 - 217

Published: Feb. 18, 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting

Language: Английский

Citations

23
The Profound Influence of Gut Microbiome and Extracellular Vesicles on Animal Health and Disease DOI Open Access
Muttiah Barathan, Sook Luan Ng, Yogeswaran Lokanathan

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4024 - 4024

Published: April 4, 2024

The animal gut microbiota, comprising a diverse array of microorganisms, plays pivotal role in shaping host health and physiology. This review explores the intricate dynamics microbiome animals, focusing on its composition, function, impact host–microbe interactions. composition intestinal microbiota animals is influenced by ecology, including factors such as temperature, pH, oxygen levels, nutrient availability, well genetic makeup, diet, habitat, stressors, husbandry practices. Dysbiosis can lead to various gastrointestinal immune-related issues impacting overall productivity. Extracellular vesicles (EVs), particularly exosomes derived from play crucial intercellular communication, influencing transporting bioactive molecules across barriers like brain barriers. Dysregulation gut–brain axis has implications for disorders highlighting potential microbiota-derived EVs disease progression. Therapeutic approaches modulate probiotics, prebiotics, microbial transplants, phage therapy, offer promising strategies enhancing performance. Studies investigating effects therapy have shown results, with improving food safety poultry production systems. Understanding complex interactions between provides valuable insights into mechanisms underlying their Further research this field essential developing effective therapeutic interventions management promote well-being animals.

Language: Английский

Citations

18
A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation DOI Open Access
Nidesha Randeni, Matteo Bordiga, Baojun Xu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9366 - 9366

Published: Aug. 29, 2024

The human gastrointestinal tract hosts a complex and dynamic community of microorganisms known as the gut microbiota, which play pivotal role in numerous physiological processes, including digestion, metabolism, immune function. Recent research has highlighted significant impact diet on microbiota composition functionality, consequential effects host health. Concurrently, there is growing evidence linking to inflammation, key factor many chronic diseases such inflammatory bowel disease (IBD), obesity, diabetes, cardiovascular (CVDs). This review explores how dietary components influence composition, these microbial changes affect pathways, therapeutic implications modulating this axis for prevention management. Beneficial patterns, Mediterranean (MD) plant-based diets, promote diverse balanced supporting anti-inflammatory pathways. Conversely, Western (WD), high saturated fats refined sugars, associated with dysbiosis increased inflammation. With all links between three variables considered, attempts offer thorough examination triangle formed by food.

Language: Английский

Citations

18
Impact of Fermented Milk On Gut Microbiota And Human Health: A Comprehensive Review DOI
M. H. Abd El‐Salam, Safinaz El‐Shibiny, Fayza M. Assem

et al.

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(3)

Published: Jan. 31, 2025

Language: Английский

Citations

2
Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential DOI
Athanasia Ioannou, Maryse D Berkhout,

Sharon Y. Geerlings

et al.

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Language: Английский

Citations

14
The Kidney in Obesity: Current Evidence, Perspectives and Controversies DOI
Dimitris Kounatidis, Natalia G. Vallianou, Theodora Stratigou

et al.

Current Obesity Reports, Journal Year: 2024, Volume and Issue: 13(4), P. 680 - 702

Published: Aug. 14, 2024

Language: Английский

Citations

8
Increased Crystallite Stability Enhances Gut Microbial Fermentability of Type 5 Resistant Starch DOI
Cuiping Wang, Chao Chen,

Sun Rong

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

The amylolytic susceptibility of starch–lipid complexes with different forms crystallites has been studied extensively, but the fermentation properties these remain little understood. Hence, in vitro fecal VI-type and VII-type were investigated present study. Compared to complexes, caused more severe disruption resulted greater acid, reducing sugar, short-chain fatty acids (SCFAs) production. Moreover, promoted a relative abundance SCFAs-producing bacteria microbiota than did complexes. Our results show that stable are utilized effectively which can be attributed binding readily Therefore, considered deliver better health benefits due their potential for producing SCFAs stimulating beneficial gut microbial activity colon.

Language: Английский

Citations

1
MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosis DOI Creative Commons
Debmalya Mitra, Gabriel K. Armijo,

E. Ober

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 10, 2025

High-dose radiation exposure results in gastrointestinal (GI) acute syndrome identified by the destruction of mucosal layer, intestinal growth barrier dysfunction, and aberrant inflammatory responses. Further, causes gut microbiome dysbiosis characterized diminished microbial diversity, mostly commensal bacteria, spread bacterial pathogens that trigger recruitment immune cells production pro-inflammatory factors lead to further GI tissue damage. Currently, there are no U.S. Food Drug Administration (FDA) approved countermeasures can treat radiation-induced injuries. To meet this critical need, Synedgen Inc. has developed a glycopolymer radiomitigator (MIIST305) is specifically targeted tract, which acts intercalating into mucus layer glycocalyx epithelial could potentially ameliorate deleterious effects radiation. Male C57BL/6J adult mice were exposed 13 Gy partial body X-irradiation with 5% bone marrow shielding MIIST305 was administered on days 1, 3, 5 post-irradiation. Approximately 85% animals survived irradiation apparently healthy until end 30-day study period. In contrast, control, Vehicle-treated past day 10 at dose. We show improved function suppressed systemic responses mediated cytokines. Taxonomic profiling community structure fecal colonic mucosa microbiota demonstrated treatment increased diversity restored abundance beneficial including Lactobacillus Bifidobacterium genera while suppressing pathogenic bacteria Enterococcus Staphylococcus compared animals. summary, novel GI-targeted therapeutic greatly enhances survival lethal protects tract from injury restoring balanced reducing Further development drug as an FDA-approved medical countermeasure importance.

Language: Английский

Citations

1
Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

Citations

1
Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases DOI Creative Commons
Shijiao Hou, Jiachen Yu,

Yongshuang Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract This article provides an overview of the advancements in application fecal microbiota transplantation (FMT) treating diseases related to intestinal dysbiosis. FMT involves transfer healthy donor into patient's body, aiming restore balance and thereby treat a variety such as recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), constipation, short syndrome (SBS), irritable (IBS). While has shown high efficacy treatment rCDI, further research is needed for its other chronic conditions. elaborates on mechanisms dysbiosis, well discusses key factors influencing effectiveness FMT, including selection, recipient characteristics, protocols, methods assessing microbiota. Additionally, it emphasizes successful FMT. Future should focus optimizing process ensure long‐term safety explore potential broader range medical

Language: Английский

Citations

1