Osteoarthritis and Cartilage, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(1)
Published: Jan. 1, 2025
ABSTRACT Background Long COVID, a heterogeneous condition characterized by range of physical and neuropsychiatric presentations, can be presented with proportion COVID‐19‐infected individuals. Methods Transcriptomic data sets those within gene expression profiles COVID‐19, long healthy controls were retrieved from the GEO database. Differentially expressed genes (DEGs) falling under COVID‐19 COVID identified R packages, contemporaneously conducted module detection was performed Modular Pharmacology Platform ( http://112.86.129.72:48081/ ). The integration both DEGs differentially module‐genes (DEMGs) regarding intersected following Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Set Enrichment Analysis (GSEA). Results There 11 62 modules, 1837 179 DEGs, as well 103 508 DEMGs acquiring for notably enriched in immune‐correlated signaling pathways. immune infiltrating cells comparatively respectively assessed via CIBERSORT, ssGSEA, xCell algorithms. Subsequently, screening hub involved employing SVM‐RFE, RF, XGBoost algorithms, logistic regression analysis. Among 67 candidate processed machine learning algorithms regression, subgroup consisting CEP55, CDCA2, MELK, DEPDC1B, at last potential biomarkers predicting risk progression into after infections. performance quantified ROC value 0.8762542, which proved combination provided highest performance. Conclusions In summary, we infection, could partly elucidation associated molecular mechanisms COVID.
Language: Английский
Citations
0
Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 687 - 687
Published: Feb. 18, 2025
The COVID-19 pandemic has led to widespread long-term complications, known as post-COVID conditions (PCC), particularly affecting vulnerable populations such cancer patients. This study aims predict the incidence of PCC in hospitalised patients using data from a longitudinal cohort conducted four major university hospitals Moscow, Russia. Clinical have been collected during acute phase and follow-ups at 6 12 months post-discharge. A total 49 clinical features were evaluated, machine learning classifiers including logistic regression, random forest, support vector (SVM), k-nearest neighbours (KNN), neural network applied PCC. Model performance was assessed area under receiver operating characteristic curve (AUC), sensitivity, specificity. KNN demonstrated highest predictive performance, with an AUC 0.80, sensitivity 0.73, specificity 0.69. Severe pre-existing comorbidities significant predictors Machine models, KNN, showed some promise predicting patients, offering potential for early intervention personalised care. These findings emphasise importance monitoring recovering mitigate impact.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 357 - 357
Published: March 1, 2025
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease, characterized by diverse array of symptoms including post-exertional malaise (PEM), severe fatigue, and cognitive impairments, all which drastically diminish the patients’ quality life. Despite its impact, no curative treatments exist, largely due to limited understanding disease’s underlying pathophysiology. Mitochondrial dysfunction, leading impaired energy production utilization, believed play key role in onset fatigue PEM, positioning it as potential pathophysiological mechanism ME/CFS. Additionally, disorder shows similarities chronic viral infections, with frequent reports immune system alterations, suggesting critical for (dys)functioning. In particular, roles senescence exhaustion—two fundamental states—remain poorly understood This state-of-the-art review explores how metabolic dysfunction may be interconnected ME/CFS, proposing that deficits directly impair function. By examining this metabolic–immune interplay, highlights pathways developing innovative therapeutic strategies target both metabolism regulation, offering hope improving patient outcomes.
Language: Английский
Citations
0
Infectious Diseases & Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Abstract Long coronavirus disease (COVID) is defined as the continuation or development of new symptoms three months after severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and that last for at least two months, with no other explanation their cause. This includes various clinical manifestations affect multiple organ systems, such complications in respiratory, cardiovascular, neurological, musculoskeletal systems. The most commonly reported include fatigue, cognitive dysfunction, dyspnea, chest pain; however, prevalence severity these vary greatly among individuals. underlying mechanisms long COVID are complex multifaceted, encompassing viral persistence, immune system mitochondrial abnormalities, endothelial impairment, alterations microbiome. Further, has imposed a significant burden on individuals, healthcare economy by impairing an individual’s quality life functional capacity, thereby increasing costs demand care rehabilitation services. review summarizes definition, phenotypes, mechanisms, current treatment advancements highlights specific research directions future investigation.
Language: Английский
Citations
0
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102400 - 102400
Published: June 28, 2024
Language: Английский
Citations
3
The Lancet Microbe, Journal Year: 2024, Volume and Issue: unknown, P. 101012 - 101012
Published: Oct. 1, 2024
Language: Английский
Citations
3
mBio, Journal Year: 2024, Volume and Issue: 15(8)
Published: Aug. 14, 2024
ABSTRACT Hematopoiesis is a tightly regulated process that gets skewed toward myelopoiesis. This restrains lymphopoiesis, but the role of lymphocytes in this not well defined. To unravel intricacies neutrophil responses COVID-19, we performed bulk RNAseq on neutrophils from healthy controls and COVID-19 patients. Principal component analysis revealed distinguishing gene expression alterations ICU ward patients displayed substantial transcriptional changes, with exhibiting more pronounced response. Intriguingly, patients, notably exhibited an enrichment immunoglobulin (Ig) B cell lineage-associated genes, suggesting potential lineage plasticity. We validated our findings larger cohort. Moreover, by reanalyzing single-cell RNA sequencing (scRNAseq) data human bone marrow (BM) granulocytes, identified cluster granulocyte-monocyte progenitors (GMP) enriched Ig genes. These cells plasticity may serve as resource depending host’s needs during severe systemic infection. distinct subset play pivotal promoting myelopoiesis response to The scRNAseq BM infected mice further supported observations humans. Finally, studies using animal model acute infection implicate IL-7/GM-CSF influencing dynamics. Elevated GM-CSF reduced IL-7 receptor imply altered hematopoiesis favoring myeloid over cells. Our provide novel insights into relationship between B-neutrophil lineages infection, hinting at implications for disease pathogenesis. IMPORTANCE study investigates dynamics focusing responses. Through are identified, particularly Notably, especially ICU, exhibit Validation patient cohort granulocytes support presence propose link implicating these stress suggest cytokine involvement dynamics, providing
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 25, 2024
This study aimed to assess plasma galectin-9 (Gal-9) and artemin (ARTN) concentrations as potential biomarkers differentiate individuals with Long COVID (LC) patients myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) from SARS-CoV-2 recovered (R) healthy controls (HCs). Receiver operating characteristic (ROC) curve analysis determined a cut-off value of Gal-9 ARTN LC the R group HCs in two independent cohorts. Positive correlations were observed between elevated levels inflammatory markers (e.g. SAA IP-10), well sCD14 I-FABP patients. also exhibited positive correlation cognitive failure scores, suggesting its role impairment ME/CFS. highlights and/or sensitive screening for discriminating controls. Notably, elevation LPS-binding protein patients, has been HIV infected individuals, suggests microbial translocation. However, despite Gal-9, we found significant decline people living (PLWH). Our provides novel important Gal-9/ARTN pathogenesis.
Language: Английский
Citations
1
International Journal of Cancer, Journal Year: 2024, Volume and Issue: 155(11), P. 1928 - 1938
Published: July 22, 2024
Abstract Immunotherapy, especially immune checkpoint blockade therapy, represents a major milestone in the history of cancer therapy. However, current response rate to immunotherapy among patients must be improved; thus, new strategies for sensitizing are urgently needed. Erythroid progenitor cells (EPCs), population immature erythroid cells, exert potent immunosuppressive functions. As newly recognized population, EPCs have not yet been effectively targeted. In this review, we summarize immunoregulatory mechanisms EPCs, CD45 + EPCs. Moreover, view regulatory effects on tumor microenvironment, propose concept EPC‐immunity, present existing targeting and discuss challenges encountered both basic research clinical applications. particular, impact treatments is discussed, laying foundation combination therapies. The aim review provide avenues improving efficacy by
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0312530 - e0312530
Published: Nov. 22, 2024
Introduction Long coronavirus disease (COVID) poses a significant burden following the 2019 (COVID-19) pandemic. Debate persists regarding impact of nonsteroidal anti-inflammatory drug (NSAID) administration during acute-phase COVID-19 on development long COVID. Hence, this study aimed to assess potential association between NSAID use and COVID using data from patients with in Korea’s National Health Insurance Service. Methods This nested case-control defined cohort as diagnosed for first time 2020 2021. The primary exposure investigated was prescriptions within 14 days initial diagnosis. We used propensity score matching create three control matched each patient group. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated after adjustment demographics, Charlson Comorbidity Index, existing comorbidities. Results Among 225,458 COVID-19, we analyzed 254 adjusted OR (aOR) higher cases versus controls (aOR, 1.79; CI, 1.00–3.19), suggesting relationship. However, sensitivity analysis revealed that increased odds acute phase became statistically non-significant 1.64; 0.90–2.99) when self-quarantine duration included covariate. Additionally, acetaminophen not significantly associated 1.12; 0.75–1.68), while antiviral drugs demonstrated stronger 3.75; 1.66–8.48). Conclusion Although suggests possible link infection stage risk well both chronic period lower COVID, significant. Further research is needed determine causal relationship various treatment options
Language: Английский
Citations
0