Lymphatic messengers: Non-antigen soluble mediators from diseased tissues to draining lymph nodes

Current Opinion in Immunology, Journal Year: 2025, Volume and Issue: 93, P. 102536 - 102536

Published: Feb. 5, 2025

Language: Английский

UV Light Exposure Induces a Type I Interferon Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes

Arthritis & Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Objective Photosensitivity occurs in ~75% of patients with lupus. Although UV light radiation (UVR) stimulates type I interferon (IFN‐I) the skin, how UVR‐induced skin inflammation leads to downstream effects is poorly understood. Tissue causes dendritic cells (DCs) migrate from organs draining lymph nodes (dLN), including a recently identified inflammatory conventional DC subset (inf cDC2) that are potent antigen‐presenting cells. To explore links between UVR and early immune response, we examined lymphocyte migration dLN normal lupus‐prone mouse strains as well role IFN‐I. Methods Mice received single dose (500 mJ/cm 2 ) on dorsal skin. Brachial inguinal were harvested at one or two days post‐UVR. Flow cytometry using Symphony A3 cytometer 15‐color staining myeloid lymphoid subsets. Statistical significance was determined by Student's t ‐test. Results Higher numbers CD64+ inf cDC2 detected after B6 mice, but not IFN receptor knockout (IFNAR KO) mice. In contrast, Trex1 mutant mice had an exaggerated IFN‐I response higher proportion dLN. Conclusion These findings reveal previously unknown relationship population They highlight this process, differences suggest may be relevance image

Language: Английский

Keratinocytes – Amplifiers of Immune Responses in Systemic Lupus Erythematosus

Current Rheumatology Reports, Journal Year: 2024, Volume and Issue: 27(1)

Published: Nov. 21, 2024

Language: Английский