Hypothetical confirmation for the anti-bacterial compound potassium succinate-succinic acid in comparison with certain succinate derivatives DOI

X.D. Divya Dexlin,

J.D. Deephlin Tarika,

Amit Kumar

et al.

Journal of Biomolecular Structure and Dynamics, Journal Year: 2023, Volume and Issue: 42(3), P. 1237 - 1248

Published: April 6, 2023

The development of antibacterial medications has recently been promoted due to the non- effective usage antibiotics and rise in severe bacterial infections. effectiveness antimicrobial therapy alternatives is constrained prevalence germs that are resistant medications. Our current study's goal favor metallic compounds for antibiotic delivery order increase regimen. Due its bioactivity, potassium succinate-succinic acid preferred because general, succinic compound greatest potential against microbial infections a natural relative acidic nature. In study, molecular geometry, band gap energies, electrostatic interactions energy distribution molecule were compared with those certain succinate derivatives. was probed using FT-IR FT-Raman analyses. Vibrational assignments pertaining different modes vibration have improved by normal coordinate analysis. chemical bond stability which largely important biological activity studied NBO docking study suggests possesses action displays minimal binding −5.3 kcal/mol can be endorsed prevention any illness. From results our studies, material would stable bioactive according FMO indicates value 4.35 eV pharmacokinetic features molecule, predicted ADMET factors drug-likeness test.Communicated Ramaswamy H. Sarma

Language: Английский

Novel advancements in the sustainable green synthesis approach of silver nanoparticles (AgNPs) for antibacterial therapeutic applications DOI
Kayeen Vadakkan, Nelson Pynadathu Rumjit, Ajit Kumar Ngangbam

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 499, P. 215528 - 215528

Published: Oct. 31, 2023

Language: Английский

Citations

65
The elements of life: A biocentric tour of the periodic table DOI

Kaleigh A. Remick,

John D. Helmann

Advances in microbial physiology/Advances in Microbial Physiology, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 127

Published: Jan. 1, 2023

Language: Английский

Citations

42
The Role of Complexes of Biogenic Metals in Living Organisms DOI Creative Commons
Irena Kostova

Inorganics, Journal Year: 2023, Volume and Issue: 11(2), P. 56 - 56

Published: Jan. 25, 2023

Biogenic metals and their various inorganic, organometallic, coordination compounds are comprehensively studied extensively used in medical practice. Since the biogenic have chemical properties corresponding to position periodic table, biological functions different. Almost all of discussed elements an ability form complexes. Furthermore, different accessible oxidation states occupied by most these enables body catalyze oxy-reduction interactions, depending on conditions. As they nature, deficiency or excess leads numerous pathological obstructions. The application metal-based as medications is connected with capability complexes, which involved many bioreactions. usefulness therapeutic diagnostic agents also pointed out.

Language: Английский

Citations

28
DNA-metal composites as bioinspired catalysts in chemical reactions DOI
Leila Hadian-Dehkordi,

Zeinab Abdi,

Armin Zarei

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 505, P. 215635 - 215635

Published: Feb. 9, 2024

Language: Английский

Citations

9
Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function DOI Open Access
Simran Kaur Aulakh, Sreejith J. Varma, Markus Ralser

et al.

Current Opinion in Genetics & Development, Journal Year: 2022, Volume and Issue: 77, P. 101987 - 101987

Published: Sept. 29, 2022

Language: Английский

Citations

30
An ancient metalloenzyme evolves through metal preference modulation DOI Creative Commons
Kacper Sendra, Anna Barwinska‐Sendra, Eilidh S. Mackenzie

et al.

Nature Ecology & Evolution, Journal Year: 2023, Volume and Issue: 7(5), P. 732 - 744

Published: April 10, 2023

Abstract Evolution creates functional diversity of proteins, the essential building blocks all biological systems. However, studies natural proteins sampled across tree life and evaluated in a single experimental system are lacking. Almost half enzymes require metals, metalloproteins tend to optimally utilize physicochemical properties specific metal co-factor. Life must adapt changes bioavailability, including those during transition from anoxic oxic Earth or pathogens’ exposure nutritional immunity. These can challenge ability metalloenzymes maintain activity, presumptively driving their evolution. Here we studied metal-preference evolution within iron/manganese superoxide dismutase (SodFM) family reactive oxygen species scavengers. We identified experimentally verified residues with conserved roles determining preference that, when combined an understanding protein’s evolutionary history, improved prediction utilization five SodFM subfamilies defined herein. By combining phylogenetics, biochemistry structural biology, demonstrate that be evolutionarily fine tuned by sliding along scale between perfect manganese iron specificities. Over history life, has been modulated multiple independent times different ecological contexts, changed short timeframes.

Language: Английский

Citations

19
Metal Homeostasis in Land Plants: A Perpetual Balancing Act Beyond the Fulfilment of Metalloproteome Cofactor Demands DOI

Ute Krämer

Annual Review of Plant Biology, Journal Year: 2024, Volume and Issue: 75(1), P. 27 - 65

Published: Jan. 26, 2024

One of life's decisive innovations was to harness the catalytic power metals for cellular chemistry. With expansion, global atmospheric and biogeochemical cycles underwent dramatic changes. Although initially harmful, they permitted evolution multicellularity colonization land. In land plants as primary producers, metal homeostasis faces heightened demands, in part because soil is a challenging environment nutrient balancing. To avoid both limitation toxicity, must maintain within tighter limits than other minerals. This review describes present model protein metalation sketches its transfer from unicellular organisms complex multicellular organisms. The inseparable connection between redox increasingly draws our attention more general regulatory roles metals. Mineral co-option, use or functions nutrition, an emerging concept beyond that nutritional immunity.

Language: Английский

Citations

8
Reconstruction of Nitrogenase Predecessors Suggests Origin from Maturase-Like Proteins DOI
Amanda K. Garcia, Bryan Kolaczkowski, Betül Kaçar

et al.

Genome Biology and Evolution, Journal Year: 2022, Volume and Issue: 14(3)

Published: Feb. 16, 2022

The evolution of biological nitrogen fixation, uniquely catalyzed by nitrogenase enzymes, has been one the most consequential biogeochemical innovations over life's history. Though understanding early fixation a longstanding goal from molecular, biogeochemical, and planetary perspectives, its origins remain enigmatic. In this study, we reconstructed evolutionary histories nitrogenases, as well homologous maturase proteins that participate in assembly active-site cofactor but are not able to fix nitrogen. We combined phylogenetic ancestral sequence inference with an analysis predicted functionally divergent sites between nitrogenases maturases infer nitrogen-fixing capabilities their shared ancestors. Our results provide constraints emergence consistent model wherein emerged maturase-like predecessors. precise functional role such predecessor protein remains speculative, our highlight contingency significant factor shaping biogeochemically essential enzyme.

Language: Английский

Citations

26
Down-selection of biomolecules to assemble “reverse micelle” with perovskites DOI Creative Commons
Haodong Wu, Yuchen Hou, Jungjin Yoon

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 26, 2024

Abstract Biological molecule-semiconductor interfacing has triggered numerous opportunities in applied physics such as bio-assisted data storage and computation, brain-computer interface, advanced distributed bio-sensing. The introduction of electronics into biological embodiment is being quickly developed it great potential providing adaptivity improving functionality. Reciprocally, introducing biomaterials semiconductors to manifest bio-mimetic functionality impactful triggering new enhanced mechanisms. In this study, we utilize the vulnerable perovskite a platform understand if certain types biomolecules can regulate lattice endow unique mechanism for stabilizing metastable lattice. Three tiers have been systematically tested results reveal fundamental formation “reverse-micelle” structure. Systematic exploration large set led discovery guiding principle down-selection which extends classic emulsion theory hybrid systems. Results demonstrate that by semiconductors, natural phenomena typically observed systems also be incorporated semiconducting crystals, perspective engineer existing synthetic materials.

Language: Английский

Citations

6
Microbes vary strategically in their metalation of mononuclear enzymes DOI Creative Commons
Sanjay Kumar Rohaun,

Sethu Ramakrishnan,

James A. Imlay

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(21)

Published: May 14, 2024

Studies have determined that nonredox enzymes are cofactored with Fe(II) the most oxidant-sensitive targets inside Escherichia coli . These use cofactors to bind and activate substrates. Because of their solvent exposure, metal can be accessed oxidized by reactive oxygen species, thereby inactivating enzyme. these participate in key physiological processes, consequences stress severe. Accordingly, when E. senses elevated levels H 2 O , it induces both a miniferritin manganese importer, enabling replacement iron atom manganese. Manganese does not react preserves enzyme activity. In this study, we examined several diverse microbes identify they customarily integrate into ribulose-5-phosphate 3-epimerase, representative family. The anaerobe Bacteroides thetaiotaomicron like uses iron. contrast, Bacillus subtilis Lactococcus lactis manganese, Saccharomyces cerevisiae zinc. latter organisms therefore well suited oxidizing environments which dwell. Similar results were obtained peptide deformylase, another essential mononuclear class. Strikingly, heterologous expression experiments show is pool within organism, rather than features protein itself, determine incorporated. Further, regardless source each exhibits highest turnover lowest We infer intrinsic catalytic properties cannot easily retuned evolution polypeptide.

Language: Английский

Citations

6