Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(11), P. 1387 - 1387
Published: Oct. 31, 2024
One-carbon
(1C)
metabolism
is
a
complex
network
of
metabolic
reactions
closely
related
to
producing
1C
units
(as
methyl
groups)
and
utilizing
them
for
different
anabolic
processes,
including
nucleotide
synthesis,
methylation,
protein
reductive
metabolism.
These
pathways
support
the
high
proliferative
rate
cancer
cells.
While
drugs
that
target
(like
methotrexate)
have
been
used
treatment,
they
often
significant
side
effects.
Therefore,
developing
new
with
minimal
effects
necessary
effective
treatment.
Methionine,
glycine,
serine
are
main
three
precursors
vital
not
only
cells
but
also
non-proliferative
in
regulating
energy
homeostasis
aging
process.
Understanding
potential
role
crucial
advancing
our
knowledge
neoplastic
progression.
This
review
provides
comprehensive
understanding
molecular
complexities
context
aging,
paving
way
researchers
explore
avenues
advanced
therapeutic
interventions
cancer.
Clinical and Translational Medicine,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 1, 2024
Abstract
Background
One‐carbon
(1C)
metabolism
is
a
metabolic
network
that
plays
essential
roles
in
biological
reactions.
In
1C
metabolism,
series
of
nutrients
are
used
to
fuel
pathways,
including
nucleotide
amino
acid
cellular
redox
defence
and
epigenetic
maintenance.
At
present,
considered
the
hallmark
cancer.
The
units
obtained
from
pathways
increase
proliferation
rate
cancer
cells.
addition,
anticancer
drugs,
such
as
methotrexate,
which
target
have
long
been
clinic.
terms
immunotherapy,
has
explore
biomarkers
connected
with
immunotherapy
response
immune‐related
adverse
events
patients.
Methods
We
collected
numerous
literatures
explain
one‐carbon
immunotherapy.
Results
this
review,
we
focus
on
important
function
enzymes
Then,
summarise
inhibitors
acting
their
potential
application
Finally,
provide
viewpoint
conclusion
regarding
opportunities
challenges
targeting
for
clinical
practicability
future.
Conclusion
Targeting
useful
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9339 - 9339
Published: Aug. 28, 2024
Cellular
metabolism
is
crucial
for
various
physiological
processes,
with
folate-dependent
one-carbon
(1C)
playing
a
pivotal
role.
Folate,
B
vitamin,
key
cofactor
in
this
pathway,
supporting
DNA
synthesis,
methylation
and
antioxidant
defenses.
In
dividing
cells,
folate
facilitates
nucleotide
biosynthesis,
ensuring
genomic
stability
preventing
carcinogenesis.
Additionally,
neurodevelopment,
essential
neural
tube
closure
central
nervous
system
formation.
Thus,
dysregulation
of
can
contribute
to
pathologies
such
as
cancer,
severe
birth
defects,
neurodegenerative
diseases.
Epidemiological
evidence
highlights
folate's
impact
on
disease
risk
its
potential
therapeutic
target.
antifolate
drugs
that
inhibit
enzymes
1C
strategies
targeting
receptors
are
current
options.
However,
cancer
complex,
varying
among
types
dietary
contexts.
conditions,
including
Alzheimer's
Parkinson's
diseases,
deficiency
exacerbates
cognitive
decline
through
elevated
homocysteine
levels,
contributing
neuronal
damage.
Clinical
trials
folic
acid
supplementation
show
mixed
outcomes,
underscoring
the
complexities
neuroprotective
effects.
This
review
integrates
knowledge
neurodegeneration,
exploring
molecular
mechanisms,
clinical
implications,
strategies,
which
provide
information
advancing
treatments.
Frontiers in Epigenetics and Epigenomics,
Journal Year:
2024,
Volume and Issue:
2
Published: July 31, 2024
The
crosstalk
between
metabolism
and
epigenetics
is
an
emerging
field
that
gaining
importance
in
different
areas
such
as
cancer
aging,
where
changes
significantly
impacts
the
cellular
epigenome,
turn
dictating
chromatin
adaptive
mechanism
to
bring
back
metabolic
homeostasis.
A
key
pathway
influencing
organism's
epigenetic
state
one-carbon
(OCM),
which
includes
folate
methionine
cycles.
Together,
these
cycles
generate
S-adenosylmethionine
(SAM),
universal
methyl
donor
essential
for
DNA
histone
methylation.
SAM
serves
sole
group
methyltransferases,
making
it
a
crucial
metabolite
modifications.
In
this
review,
we
will
discuss
how
its
byproduct,
S-adenosylhomocysteine
(SAH),
along
with
enzymes
cofactors
involved
OCM,
may
function
compartments,
particularly
nucleus,
directly
regulate
epigenome
aging
cancer.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Abstract
Background
Folate
metabolism
is
crucial
for
fetal
development,
while
per-
and
polyfluoroalkyl
substances
(PFAS)
are
associated
with
adverse
birth
outcomes
lower
folate
levels.
However,
no
study
tested
the
interaction
between
PFAS
exposure
genetic
variations
in
pathway
on
outcomes.
The
investigated
whether
variants
modify
association
prenatal
Methods
We
analyzed
data
from
338
mother-infant
pairs
Taiwan
Birth
Panel
Study.
Cord
blood
concentrations
of
four
were
measured
using
ultra-performance
liquid
chromatography–tandem
mass
spectrometry.
Infant
genotypes
assessed
Biobank
Array,
we
focused
three
previously
identified
single
nucleotide
polymorphisms
(SNPs)
related
to
five
SNPs
metabolism.
Gene-environment
interactions
evaluated
generalized
linear
regression
two
mixture
models
(quantile
g-computation
Bayesian
kernel
machine
regression).
Results
Prenatal
PFOS,
PFUA,
weight,
associations
weight
head
circumference
varied
by
variants.
found
PFNA
MTNR1B
rs10830963,
a
weight-related
SNP.
Also,
MTR
rs1805087
AG/GG
carriers
had
greater
PFOS
mixture-related
reductions.
Meanwhile,
there
stronger
evidence
mixture-birth
HMGA2
rs1351394
CC
rs1042725
TT
carriers.
Conclusion
Genotypes
size
modified
circumference.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: April 28, 2025
Oxidative
stress(OS)
is
implicated
in
various
diseases,
and
the
methylation
cycle
plays
a
critical
role
numerous
biological
processes
including
DNA
antioxidant
defense.
We
aimed
to
investigate
relationship
between
oxidative
balance
score
(OBS)
cycle.
The
study
enrolled
28,061
adults
≥20
years
old
from
NHANES
2003-2014.
Methylation
biomarkers
included
serum
folate,
RBC
vitamin
B6,
B12,
homocysteine
(HCY),
methylmalonic
acid
(MMA).
OBS
was
scored
by
20
dietary
lifestyle
factors.
employed
weighted
linear
regression
restricted
cubic
spline
(RCS)
models
analyze
correlations
among
OBS,
In
nationally
representative
cohort
of
US
(mean
age:
47.04
±
0.25
years;
51.76%
female),
demonstrated
significant
associations
with
key
biomarkers.
After
adjusting
for
potential
confounders,
exhibited
positive
association
negative
correlation
HCY
(all
P
trend
<
0.001),
no
MMA
(P
=
0.07).
Higher
correlated
increased
levels
decreased
0.001).
Similarly,
higher
corresponded
as
well
0.05).
Stratified
analyses
that
had
strong
HCY.
Additionally,
observed
elderly
population
(≥
60
old)
when
stratified
age.
RCS
analysis
revealed
increase
B12
also
increased,
while
decreased.
Our
findings
demonstrate
positively
associated
folate
vitamins
B6/B12,
negatively
