O-GlcNAcylation of FBP1 promotes pancreatic cancer progression by facilitating its Lys48-linked polyubiquitination in hypoxic environments DOI Creative Commons
Yi Zhu, Xiaoman He, Xiaojing Ma

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract Fructose-1,6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, is important for cancer progression. The post-translational regulation of FBP1 hypoxic environments still unclear. Here, we report that down-regulated and low expression level predicts poor prognosis pancreatic cancer. Hypoxic environment makes more prone to degradation this effect can be reversed by inhibiting global O-GlcNAcylation signalling. O-linked N-acetylglucosamine transferase (OGT) interact with induce its at serine 47 residue (FBP1-S47) modulate protein function cell. FBP1-S47 promote also influence the canonical HIF-1α target genes involved glucose metabolism, resulting an increase uptake lactate secretion cells. In addition, facilitates K48-linked polyubiquitination lysine 51 (FBP1-K51), which GlcNAc moiety serve as prerequisite ubiquitin ligase. (K51) mediated progression similarly FBP1-S47. Our data uncover mechanism whereby regulated O-GlcNAcylation-polyubiquitination axis, paving way cell metabolic reprogram.

Language: Английский

Targeting O-GlcNAcylation in cancer therapeutic resistance: The sugar Saga continues DOI
Lulu Chen,

Mengxue Hu,

Luojun Chen

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216742 - 216742

Published: Feb. 23, 2024

Language: Английский

Citations

11
Mechanisms of metabolism-coupled protein modifications DOI
Bingsen Zhang, Frank C. Schroeder

Nature Chemical Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

1
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research DOI Creative Commons
Shaunak Deota, Julie S. Pendergast, Ullas Kolthur‐Seetharam

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

1
Epigenetic control of circadian clocks by environmental signals DOI
Xiao‐Lan Liu, Zeyu Duan,

Muqun Yu

et al.

Trends in Cell Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Language: Английский

Citations

5
O-GlcNAcylation: A Major Nutrient/Stress Sensor that Regulates Cellular Physiology DOI Creative Commons
Lance Wells, Gerald W. Hart

Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: 300(9), P. 107635 - 107635

Published: Aug. 5, 2024

Language: Английский

Citations

4
O-GlcNAcylation of FBP1 promotes pancreatic cancer progression by facilitating its Lys48-linked polyubiquitination in hypoxic environments DOI Creative Commons
Yi Zhu, Xiaoman He, Xiaojing Ma

et al.

Oncogenesis, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 22, 2025

Fructose-1,6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, is important for cancer progression. The post-translational regulation of FBP1 hypoxic environments still unclear. Here, we report that down-regulated, and low expression level predicts poor prognosis pancreatic cancer. A environment makes more prone to degradation, this effect can be reversed by inhibiting global O-GlcNAcylation signalling. O-linked N-acetylglucosamine transferase (OGT) interacts with induces its at serine 47 residue (FBP1-S47) modulate protein function cells. FBP1-S47 promotes degradation also influences the canonical HIF-1α target genes involved glucose metabolism, resulting an increase uptake lactate secretion In addition, facilitates K48-linked polyubiquitination lysine 51 (FBP1-K51), which GlcNAc moiety serve as prerequisite ubiquitin ligase. (K51) mediated promote progression, similarly FBP1-S47. Our data uncover mechanism whereby regulated O-GlcNAcylation-polyubiquitination axis, paving way cell metabolic reprogramming.

Language: Английский

Citations

0
The circadian clock at the intersection of metabolism and aging – emerging roles of metabolites DOI Creative Commons
Yue Dong, Sin Man Lam, Yan Li

et al.

Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Decoding the Role of O-GlcNAcylation in Hepatocellular Carcinoma DOI Creative Commons
Xinyu Zhou,

Sirui Hang,

Qingqing Wang

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 908 - 908

Published: July 25, 2024

Post-translational modifications (PTMs) influence protein functionality by modulating stability, localization, and interactions with other molecules, thereby controlling various cellular processes. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, SUMOylation, methylation, sulfation, nitrosylation. Among these modifications, O-GlcNAcylation has been shown to play a critical role in cancer development progression, especially hepatocellular carcinoma (HCC). This review outlines the of progression HCC. Moreover, we delve into underlying mechanisms HCC highlight compounds that target O-GlcNAc transferase (OGT) O-GlcNAcase (OGA) improve treatment outcomes. Understanding will offer insights potential therapeutic strategies targeting OGT OGA, which could for patients

Language: Английский

Citations

3
Controlling pyroptosis through post-translational modifications of gasdermin D DOI
Na Zhang, Daichao Xu

Developmental Cell, Journal Year: 2025, Volume and Issue: 60(7), P. 994 - 1007

Published: April 1, 2025

Language: Английский

Citations

0
O-GlcNAc informatics: advances and trends DOI
Chunyan Hou, Weiyu Li, Yaoxiang Li

et al.

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Language: Английский

Citations

2