Increased expression of DNAJC7 promotes the progression of hepatocellular carcinoma by influencing the cell cycle and immune microenvironment DOI Creative Commons
Jiaxing Chen, Zhizhao Yang, Yongqiang Cui

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(5)

Published: May 2, 2025

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide owing to lack effective and early diagnostic tools therapeutic approaches. DNAJC7, a member DnaJ heat shock family, crucial in protein folding stability; however, its specific functions mechanisms HCC remain unclear. This study aimed explore role DNAJC7 progression evaluate potential clinical significance as prognostic marker. Public databases (TCGA, ICGC, GEO, TIMER) were used assess expression, correlations with parameters, related signaling pathways. Proliferation, migration, invasion, cell cycle assays performed function HCC. Immune infiltration associations checkpoint proteins analyzed using TIMER, Gene Set Enrichment Analysis (GSEA) was enriched expression higher tissues than adjacent normal associated advanced malignancy poor prognosis, including lower overall survival, progression-free disease-free survival. knockdown resulted reduced malignant behavior cells, S-phase arrest. Increased immune presence immunological molecules, CTLA4 PD-1. GSEA highlighted activation key pathways, WNT regulation. regulates tumor proliferation, evasion by acting an oncogene It can serve biomarker treatment target for

Language: Английский

Epigenetic and Post-Translational Modifications in Ferroptosis Regulation and Hepatocellular Carcinoma: New Frontiers in Therapeutic Targeting DOI

Soheil Bolandi,

Samaneh Dodge,

Zahra Zahed

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155991 - 155991

Published: April 1, 2025

Language: Английский

Citations

1
Post-translational modifications in hepatocellular carcinoma: unlocking new frontiers in immunotherapy DOI Creative Commons

Yuexian Piao,

Naicui Zhai,

Xiaoling Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 18, 2025

Liver cancer, particularly hepatocellular carcinoma (HCC), is one of the most common and aggressive malignancies worldwide. Immunotherapy has shown promising results in treating HCC, but its efficacy often limited by complex mechanisms immune evasion. Post-translational modifications (PTMs) proteins play a critical role regulating responses within tumor microenvironment (TME). These influence protein function, stability, interactions, which either promote or inhibit cell activity cancer. In this mini-review, we explore diverse PTMs that impact evasion liver including glycosylation, phosphorylation, acetylation, ubiquitination. We focus on how these regulate key checkpoint molecules such as PD-L1, CTLA-4, TCR complex. Furthermore, discuss potential targeting combination with existing immunotherapies to enhance effectiveness treatment HCC. Understanding regulation may lead development novel therapeutic strategies overcome resistance immunotherapy

Language: Английский

Citations

0
The oncogenic role of FOXM1 in hepatocellular carcinoma: molecular mechanisms, clinical significance, and therapeutic potentials DOI
Fengtian He, He Liu, Fangcheng Zhao

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Citations

0
Increased expression of DNAJC7 promotes the progression of hepatocellular carcinoma by influencing the cell cycle and immune microenvironment DOI Creative Commons
Jiaxing Chen, Zhizhao Yang, Yongqiang Cui

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(5)

Published: May 2, 2025

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide owing to lack effective and early diagnostic tools therapeutic approaches. DNAJC7, a member DnaJ heat shock family, crucial in protein folding stability; however, its specific functions mechanisms HCC remain unclear. This study aimed explore role DNAJC7 progression evaluate potential clinical significance as prognostic marker. Public databases (TCGA, ICGC, GEO, TIMER) were used assess expression, correlations with parameters, related signaling pathways. Proliferation, migration, invasion, cell cycle assays performed function HCC. Immune infiltration associations checkpoint proteins analyzed using TIMER, Gene Set Enrichment Analysis (GSEA) was enriched expression higher tissues than adjacent normal associated advanced malignancy poor prognosis, including lower overall survival, progression-free disease-free survival. knockdown resulted reduced malignant behavior cells, S-phase arrest. Increased immune presence immunological molecules, CTLA4 PD-1. GSEA highlighted activation key pathways, WNT regulation. regulates tumor proliferation, evasion by acting an oncogene It can serve biomarker treatment target for

Language: Английский

Citations

0