Epigenetic and Post-Translational Modifications in Ferroptosis Regulation and Hepatocellular Carcinoma: New Frontiers in Therapeutic Targeting
Soheil Bolandi,
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Samaneh Dodge,
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Zahra Zahed
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et al.
Pathology - Research and Practice,
Journal Year:
2025,
Volume and Issue:
unknown, P. 155991 - 155991
Published: April 1, 2025
Language: Английский
Post-translational modifications in hepatocellular carcinoma: unlocking new frontiers in immunotherapy
Yuexian Piao,
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Naicui Zhai,
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Xiaoling Zhang
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et al.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 18, 2025
Liver
cancer,
particularly
hepatocellular
carcinoma
(HCC),
is
one
of
the
most
common
and
aggressive
malignancies
worldwide.
Immunotherapy
has
shown
promising
results
in
treating
HCC,
but
its
efficacy
often
limited
by
complex
mechanisms
immune
evasion.
Post-translational
modifications
(PTMs)
proteins
play
a
critical
role
regulating
responses
within
tumor
microenvironment
(TME).
These
influence
protein
function,
stability,
interactions,
which
either
promote
or
inhibit
cell
activity
cancer.
In
this
mini-review,
we
explore
diverse
PTMs
that
impact
evasion
liver
including
glycosylation,
phosphorylation,
acetylation,
ubiquitination.
We
focus
on
how
these
regulate
key
checkpoint
molecules
such
as
PD-L1,
CTLA-4,
TCR
complex.
Furthermore,
discuss
potential
targeting
combination
with
existing
immunotherapies
to
enhance
effectiveness
treatment
HCC.
Understanding
regulation
may
lead
development
novel
therapeutic
strategies
overcome
resistance
immunotherapy
Language: Английский
The oncogenic role of FOXM1 in hepatocellular carcinoma: molecular mechanisms, clinical significance, and therapeutic potentials
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 23, 2025
Language: Английский
Increased expression of DNAJC7 promotes the progression of hepatocellular carcinoma by influencing the cell cycle and immune microenvironment
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2025,
Volume and Issue:
151(5)
Published: May 2, 2025
Hepatocellular
carcinoma
(HCC)
is
the
leading
cause
of
cancer-related
mortality
worldwide
owing
to
lack
effective
and
early
diagnostic
tools
therapeutic
approaches.
DNAJC7,
a
member
DnaJ
heat
shock
family,
crucial
in
protein
folding
stability;
however,
its
specific
functions
mechanisms
HCC
remain
unclear.
This
study
aimed
explore
role
DNAJC7
progression
evaluate
potential
clinical
significance
as
prognostic
marker.
Public
databases
(TCGA,
ICGC,
GEO,
TIMER)
were
used
assess
expression,
correlations
with
parameters,
related
signaling
pathways.
Proliferation,
migration,
invasion,
cell
cycle
assays
performed
function
HCC.
Immune
infiltration
associations
checkpoint
proteins
analyzed
using
TIMER,
Gene
Set
Enrichment
Analysis
(GSEA)
was
enriched
expression
higher
tissues
than
adjacent
normal
associated
advanced
malignancy
poor
prognosis,
including
lower
overall
survival,
progression-free
disease-free
survival.
knockdown
resulted
reduced
malignant
behavior
cells,
S-phase
arrest.
Increased
immune
presence
immunological
molecules,
CTLA4
PD-1.
GSEA
highlighted
activation
key
pathways,
WNT
regulation.
regulates
tumor
proliferation,
evasion
by
acting
an
oncogene
It
can
serve
biomarker
treatment
target
for
Language: Английский