Regulation of Joint Tissues and Joint Function: Is There Potential for Lessons to Be Learned Regarding Regulatory Control from Joint Hypermobility Syndromes?
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1256 - 1256
Published: Jan. 31, 2025
Normal
development
of
joints
starts
in
utero
with
the
establishment
a
cellular
and
extracellular
matrix
template.
Following
birth,
individual
joint
tissues
grow
mature
response
to
biochemical
mechanical
signals,
leading
coordinated
pattern
further
maturation
resulting
that
functions
as
an
organ
system.
Each
develops
matures
system
defined
by
biomechanical
environment
which
it
will
function.
For
those
hypermobility
syndromes,
either
specific
genetic
mutations
or
not
(i.e.,
Ehlers–Danlos
syndrome,
Marfan
Loey–Dietz
hypermobility-type
syndrome),
this
process
is
partially
compromised,
but
many
aspects
tissue
function
retained
such
organs
form
retain
partial
function,
compromised.
Comparing
characteristics
what
known
regarding
development,
growth,
maturation,
stressors
puberty,
pregnancy,
aging
without
leads
conclusion
have
systems
may
be
compromised
via
failure
undergo
possibly
defective
mechanotransduction.
Given
breadth
involved
characterization
concept
reveal
commonalities
their
impact
on
inform
regulatory
normal
functional
integrity.
This
review/perspective
piece
attempt
detail
comparisons
summarize
how
study
aid
understanding.
Language: Английский
Restoring articular cartilage: insights from structure, composition and development
Nature Reviews Rheumatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Language: Английский
Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 8, 2024
During
inner
ear
semicircular
canal
morphogenesis
in
zebrafish,
patterned
canal-genesis
zones
express
genes
for
extracellular
matrix
component
synthesis.
These
include
hyaluronan
and
the
hyaluronan-binding
chondroitin
sulfate
proteoglycan
Versican,
which
are
abundant
matrices
of
many
developing
organs.
Charged
hyaluronate
polymers
play
a
key
role
through
osmotic
swelling.
However,
developmental
factor(s)
that
control
synthesis
components
regulation
density
swelling
unknown.
Here,
we
identify
transcription
factor,
Lmx1b,
as
positive
transcriptional
regulator
hyaluronan,
crucial
morphogenesis.
We
show
Versican
regulates
its
protein
core,
whereas
charged
side
chains
contribute
to
hyaluronate.
Versican-tuned
properties
may
be
broadly
used
mechanism
with
important
implications
understanding
diseases
where
these
impaired,
hydrogel
engineering
tissue
regeneration.
Language: Английский