Recent advances in sustainable synthesis of N-heterocycles following acceptorless dehydrogenative coupling protocol using alcohols

Organic Chemistry Frontiers, Journal Year: 2021, Volume and Issue: 8(11), P. 2673 - 2709

Published: Jan. 1, 2021

In this review, we have summarized various aspects of homogeneous and heterogeneously catalyzed recent advancements in the synthesis heterocycles following ADC approach.

Language: Английский

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Transition metals-catalyzed amination of biomass feedstocks for sustainable construction of N-heterocycles

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 502, P. 215622 - 215622

Published: Dec. 26, 2023

Language: Английский

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Harnessing alcohols as sustainable reagents for late-stage functionalisation: synthesis of drugs and bio-inspired compounds

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(9), P. 4607 - 4647

Published: Jan. 1, 2024

This review collectively discussed the utilisation of alcohols in various organic transformations and their application toward intermediates drugs, drug derivatives natural product-like molecules.

Language: Английский

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Ruthenium Pincer Complex Catalyzed Selective Synthesis of C‐3 Alkylated Indoles and Bisindolylmethanes Directly from Indoles and Alcohols

Advanced Synthesis & Catalysis, Journal Year: 2020, Volume and Issue: 362(14), P. 2902 - 2910

Published: May 7, 2020

Abstract Herein, we presented Ru‐SNS complex that serves as a useful catalyst for C‐3 alkylation of 1H‐indoles with various aliphatic primary and secondary alcohols including cyclic well benzylic alcohols. The selective synthesis bisindolylmethane derivatives is also achieved from the same set indole alcohol just by altering reaction parameters. Furthermore, sustainable alkylated indoles directly 2‐(2‐nitrophenyl)ethan‐1‐ol catalysed Ru‐complex via “borrowing hydrogen” strategy reported. This protocol provides an atom‐economical route to access structurally important compounds like arundine, vibrindole A tryptamine based derivatives. magnified image

Language: Английский

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Tandem transformations and multicomponent reactions utilizing alcohols following dehydrogenation strategy

Organic & Biomolecular Chemistry, Journal Year: 2020, Volume and Issue: 18(12), P. 2193 - 2214

Published: Jan. 1, 2020

In this review, the progress of tandem transformation nitro, nitrile and azide functionalities is summarised to develop new C–C C–N bonds as well multi-component reactions using alcohols.

Language: Английский

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Iridium supported on porous polypyridine-oxadiazole as high-activity and recyclable catalyst for the borrowing hydrogen reaction

Green Chemistry, Journal Year: 2022, Volume and Issue: 24(6), P. 2602 - 2612

Published: Jan. 1, 2022

Porous polypyridine-oxadiazole supported iridium catalysts (PPO-Ir) revealed high catalytic activity for the reaction of dimethyl-6-aminouracil (including 1,3-dimethylbarbituric acid, 2-aminobenzylamine) with alcohols.

Language: Английский

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Well-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines

The Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 87(13), P. 8351 - 8367

Published: June 21, 2022

Herein, we report a simple, phosphine-free, and inexpensive catalytic system based on manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles, pyridines from amino alcohols ketones. Several control experiments, kinetic studies, DFT calculations were carried out to support the plausible reaction mechanism. We also detected two potential intermediates in cycle using ESI-MS analysis. Based these metal-ligand cooperative mechanism was proposed.

Language: Английский

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Unleashing Selective Reduction and Reductive Methylation of N-Heterocycles Using Methanol via Strategic Reaction Condition Modulation

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 3008 - 3022

Published: Feb. 5, 2025

Language: Английский

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Iron Catalyzed Synthesis of Pyrimidines Under Air

Advanced Synthesis & Catalysis, Journal Year: 2019, Volume and Issue: 362(3), P. 594 - 600

Published: Nov. 21, 2019

Abstract Herein we report an iron‐catalyzed multicomponent dehydrogenative functionalization of alcohols to pyrimidines under atmospheric conditions. Using a well‐defined Fe(II)‐complex featuring redox noninnocent 2‐phenylazo‐(1,10‐phenanthroline) ligand, as catalyst, wide array 2,4,6‐trisubstituted were prepared via coupling primary and secondary with amidines air at 100 °C. A few control experiments carried out understand unveil the plausible reaction mechanism. magnified image

Language: Английский

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Recent Advances in Homogeneous Catalysis via Metal–Ligand Cooperation Involving Aromatization and Dearomatization

Catalysts, Journal Year: 2020, Volume and Issue: 10(6), P. 635 - 635

Published: June 7, 2020

Recently, an increasing number of metal complex catalysts have been developed to achieve the activation or transformation substrates based on cooperation between atom and its ligands. In such “cooperative catalysis,” ligand not only is bound metal, where it exerts steric electronic effects, but also functionally varies structure during elementary processes catalytic reaction. this review article, we focus metal–ligand involving aromatization dearomatization ligand, thus introducing newest developments examples homogeneous reactions.

Language: Английский

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