Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(11), P. 4386 - 4464
Published: Jan. 1, 2022
The
emerging
field
of
organometallic
catalysis
has
shifted
towards
research
on
Earth-abundant
transition
metals
due
to
their
ready
availability,
economic
advantage,
and
novel
properties.
In
this
case,
manganese,
the
third
most
abundant
transition-metal
in
Earth's
crust,
emerged
as
one
leading
competitors.
Accordingly,
a
large
number
molecularly-defined
Mn-complexes
been
synthesized
employed
for
hydrogenation,
dehydrogenation,
hydroelementation
reactions.
regard,
catalyst
design
is
based
three
pillars,
namely,
metal-ligand
bifunctionality,
ligand
hemilability,
redox
activity.
Indeed,
developed
catalysts
not
only
differ
chelating
atoms
they
possess
but
also
working
principles,
thereby
different
turnover
numbers
product
molecules.
Hence,
critical
assessment
molecularly
defined
manganese
terms
atoms,
reaction
conditions,
mechanistic
pathway,
significant.
Herein,
we
analyze
complexes
catalytic
activity,
versatility
allow
multiple
transformations
routes
convert
substrates
target
This
article
will
be
helpful
get
significant
insight
into
design,
aiding
design.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(48), P. 25188 - 25202
Published: June 17, 2021
N-Heterocycles,
such
as
pyrroles,
pyrimidines,
quinazolines,
and
quinoxalines,
are
important
building
blocks
for
organic
chemistry
the
fine-chemical
industry.
For
their
synthesis,
catalytic
borrowing
hydrogen
acceptorless
dehydrogenative
coupling
reactions
of
alcohols
sustainable
reagents
have
received
significant
attention
in
recent
years.
To
overcome
problems
product
separation
catalyst
reusability,
several
metal-based
heterogeneous
catalysts
been
reported
to
achieve
these
transformations
with
good
yields
selectivity.
In
this
Minireview,
we
summarize
developments
using
both
noble
non-noble
synthesize
N-heterocycles
from
N-nucleophiles
via
dehydrogenation
or
methodologies.
Furthermore,
Minireview
introduces
strategies
preparation
functionalization
corresponding
catalysts,
discusses
reaction
mechanisms
roles
metal
electronic
states,
influence
support
Lewis
acid-base
properties
on
reactions.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(13), P. 8351 - 8367
Published: June 21, 2022
Herein,
we
report
a
simple,
phosphine-free,
and
inexpensive
catalytic
system
based
on
manganese(II)
complex
for
synthesizing
different
important
N-heterocycles
such
as
quinolines,
pyrroles,
pyridines
from
amino
alcohols
ketones.
Several
control
experiments,
kinetic
studies,
DFT
calculations
were
carried
out
to
support
the
plausible
reaction
mechanism.
We
also
detected
two
potential
intermediates
in
cycle
using
ESI-MS
analysis.
Based
these
metal-ligand
cooperative
mechanism
was
proposed.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(2), P. 514 - 518
Published: Jan. 9, 2024
In
this
work,
we
have
constructed
three
new
Co(II)
complexes
in
which
steric
features
govern
their
structural
geometry.
The
metal
ligand-cooperation
behavior
of
the
alkoxy
arm
is
utilized
to
explore
catalytic
activities
these
with
respect
dehydrogenation.
A
wide
range
C-3-substituted
quinoline
and
quinazoline
derivatives
were
synthesized
high
yields.
developed
protocol's
usefulness
enhanced
by
chemoselective
transformation
different
fatty
alcohols
synthesize
heterocycles
having
distal
unsaturation.
Various
kinetic,
mechanistic,
control
studies
conducted
comprehend
reaction
route.
European Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
2021(46), P. 6206 - 6223
Published: Nov. 4, 2021
Abstract
Acceptorless
dehydrogenative
coupling
reactions
(ADC)
and
hydrogen
transfer
strategies
(HT)
provide
a
powerful
tool
in
the
multicomponent
formation
of
N
‐
heterocycles.
A
broad
variety
complex
products
can
be
obtained
starting
from
simple,
cheap
commercially
available
reagents.
The
protocols
are
highly
atom‐efficient,
as
water,
dihydrogen,
or
some
cases
peroxide,
only
by‐products.
Moreover,
neither
further
reducing
oxidizing
agents,
nor
external
general
required.
Especially
base
metal‐catalyzed
become
ever
more
important.
Therefore,
recent
years,
various
different
manganese,
iron,
cobalt,
nickel
copper
catalysts
have
been
developed.
This
Minireview
highlights
progress
that
has
made
by
using
abundant
metal
complexes
to
promote
cyclizations
for
heterocycles
compares
their
performance
with
noble
catalyst
systems.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(19), P. 12596 - 12607
Published: Sept. 26, 2022
We
present
a
convenient
and
efficient
protocol
to
synthesize
quinolines
quinazolines
in
one
pot
under
mild
conditions.
A
variety
of
substituted
were
synthesized
good
excellent
yields
(up
97%
yield)
from
the
dehydrogenative
cyclizations
2-aminoaryl
alcohols
ketones
catalyzed
by
readily
available
Co(OAc)2·4H2O.
This
cobalt
catalytic
system
also
showed
high
activity
reactions
2-aminobenzyl
with
nitriles,
affording
various
quinazoline
derivatives
95%
yield).
The
offers
an
environmentally
benign
approach
for
synthesis
N-heterocycles
employing
earth-abundant
salt
ligand-free
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(6), P. 3989 - 4000
Published: March 8, 2022
Herein,
we
demonstrated
Mn-catalyzed
selective
C-3
functionalization
of
indoles
with
alcohols.
The
developed
catalyst
can
also
furnish
bis(indolyl)methanes
from
the
same
set
substrates
under
slightly
modified
reaction
conditions.
Mechanistic
studies
reveal
that
is
going
via
a
borrowing
hydrogen
pathway.
To
highlight
practical
utility,
diverse
range
including
nine
structurally
important
drug
molecules
are
synthesized.
Furthermore,
introduced
one-pot
cascade
strategy
for
synthesizing
functionalized
directly
2-aminophenyl
ethanol
and
alcohol.
