Enhanced lysosomal escape of cell penetrating peptide-functionalized metal–organic frameworks for co-delivery of survivin siRNA and oridonin DOI Creative Commons
Mengru Cai,

Yu Yao,

Dongge Yin

et al.

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 646, P. 370 - 380

Published: April 28, 2023

In recent years, small interfering RNA (siRNA) has been widely used in the treatment of human diseases, especially tumors, and shown great appeal. However, clinical application siRNA faces several challenges. Insufficient efficacy, poor bioavailability, stability, lack responsiveness to a single therapy are main problems affecting tumor therapy. Here, we designed cell-penetrating peptide (CPP)-modified metal organic framework nanoplatform (named PEG-CPP33@ORI@survivin siRNA@ZIF-90, PEG-CPP33@NPs) for targeted co-delivery oridonin (ORI), natural anti-tumor active ingredient) survivin vivo. This can improve stability bioavailability efficacy monotherapy. The high drug-loading capacity pH-sensitive properties zeolite imidazolides endowed PEG-CPP33@NPs with lysosomal escape abilities. Polyethylene glycol (PEG)-conjugated CPP (PEG-CPP33) coating significantly improved uptake vitro results showed that ORI greatly enhanced effect PEG-CPP33@NPs, demonstrating synergistic between siRNA. summary, novel nanobiological platform loaded presented herein advantages cancer therapy, provides an attractive strategy chemotherapy gene

Language: Английский

Recent advances of the core–shell MOFs in tumour therapy DOI

Yana Zeng,

Guihua Xu, Xiangyang Kong

et al.

International Journal of Pharmaceutics, Journal Year: 2022, Volume and Issue: 627, P. 122228 - 122228

Published: Sept. 24, 2022

Language: Английский

Citations

46
A 3,8-connected Cd(ii)-based metal–organic framework as an appropriate luminescent sensor for the antibiotic sulfasalazine DOI
Xiu‐Yan Dong, Duqingcuo Li, Yuyan Li

et al.

CrystEngComm, Journal Year: 2022, Volume and Issue: 24(40), P. 7157 - 7165

Published: Jan. 1, 2022

A new 3,8-connected Cd( ii )-based metal–organic framework synthesized and used as an appropriate luminescent sensor for the antibiotic sulfasalazine.

Language: Английский

Citations

45
Recent advances in Metal-Organic Frameworks as nanocarriers for triggered release of anticancer drugs: Brief history, biomedical applications, challenges and future perspective DOI

Syeda Fiza Fatima,

Rana Sabouni,

Renuka Garg

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 225, P. 113266 - 113266

Published: March 15, 2023

Language: Английский

Citations

41
NH2-Modified UiO-66: Structural Characteristics and Functional Properties DOI Creative Commons
К. Л. Тимофеев, Sergei A. Kulinich, Tamara Kharlamova

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(9), P. 3916 - 3916

Published: May 5, 2023

The development of new functional materials based on metal-organic frameworks (MOFs) for adsorption and catalytic applications is one the promising trends modern science. Zr-based MOFs, specifically UiO-66, are considered as supports metallic catalysts 5-hydroxymethylfurfural platform molecule reduction into valuable products. present work focused effect NH2 modification UiO-66 its structure properties. samples were prepared by a solvothermal method. obtained was studied X-ray diffraction, IR spectroscopy, UV-visible low-temperature nitrogen adsorption. Basic properties investigated HCl CH3COOH adsorption, electrokinetic electrophoretic light scattering. UiO-66-NH2 with different contents aminoterephthalate linkers successfully prepared. A gradual decrease in specific surface area fraction micropores diameter ~0.9 nm observed an increase content. proportional total number basic sites established content up to 75%. At same time, noticeable their strength higher observed.

Language: Английский

Citations

32
Enhanced lysosomal escape of cell penetrating peptide-functionalized metal–organic frameworks for co-delivery of survivin siRNA and oridonin DOI Creative Commons
Mengru Cai,

Yu Yao,

Dongge Yin

et al.

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 646, P. 370 - 380

Published: April 28, 2023

In recent years, small interfering RNA (siRNA) has been widely used in the treatment of human diseases, especially tumors, and shown great appeal. However, clinical application siRNA faces several challenges. Insufficient efficacy, poor bioavailability, stability, lack responsiveness to a single therapy are main problems affecting tumor therapy. Here, we designed cell-penetrating peptide (CPP)-modified metal organic framework nanoplatform (named PEG-CPP33@ORI@survivin siRNA@ZIF-90, PEG-CPP33@NPs) for targeted co-delivery oridonin (ORI), natural anti-tumor active ingredient) survivin vivo. This can improve stability bioavailability efficacy monotherapy. The high drug-loading capacity pH-sensitive properties zeolite imidazolides endowed PEG-CPP33@NPs with lysosomal escape abilities. Polyethylene glycol (PEG)-conjugated CPP (PEG-CPP33) coating significantly improved uptake vitro results showed that ORI greatly enhanced effect PEG-CPP33@NPs, demonstrating synergistic between siRNA. summary, novel nanobiological platform loaded presented herein advantages cancer therapy, provides an attractive strategy chemotherapy gene

Language: Английский

Citations

26