Small Methods,
Journal Year:
2023,
Volume and Issue:
8(3)
Published: Nov. 23, 2023
Abstract
Zeolite
imidazole
framework‐8
(ZIF‐8)
is
the
most
prestigious
one
among
zeolitic
imidazolate
framework
(ZIF)
with
tunable
dimensions
and
unique
morphological
features.
Utilizing
its
synthetic
adjustability
structural
regularity,
ZIF‐8
exhibits
enhanced
flexibility,
allowing
for
a
wide
range
of
functionalities,
such
as
loading
nanoparticle
components
while
preserving
biomolecules
activity.
Extensive
efforts
are
made
from
investigating
synthesis
techniques
to
develop
novel
applications
over
decades.
In
this
review,
development
recent
progress
various
approaches
briefly
summarized.
addition,
interesting
properties
adjustable
porosity,
excellent
thermal,
chemical
stabilities
introduced.
Further,
five
representative
biomedical
highlighted
based
on
above
physicochemical
properties.
Finally,
remaining
challenges
offered
insights
into
future
outlook
also
discussed.
This
review
aims
understand
co‐relationships
between
structures
offering
opportunity
construct
attractive
materials
promising
characteristics.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 1, 2024
The
need
for
tumor
postoperative
treatments
aimed
at
recurrence
prevention
and
tissue
regeneration
have
raised
wide
considerations
in
the
context
of
design
functionalization
implants.
Herein,
an
injectable
hydrogel
system
encapsulated
with
anti-tumor,
anti-oxidant
dual
functional
nanoparticles
has
been
developed
order
to
prevent
relapse
after
surgery
promote
wound
repair.
utilization
biocompatible
gelatin
methacryloyl
(GelMA)
was
geared
towards
localized
therapeutic
intervention.
Zeolitic
imidazolate
framework-8@ceric
oxide
(ZIF-8@CeO2,
ZC)
(NPs)
were
purposefully
devised
their
proficiency
as
reactive
oxygen
species
(ROS)
scavengers.
Furthermore,
GelMA
hydrogels
loaded
ZC
NPs
carrying
doxorubicin
(ZC-DOX@GEL)
tailored
multifunctional
implants,
ensuring
efficacious
eradication
residual
cells
alleviation
oxidative
stress.
In
vitro
vivo
experiments
conducted
substantiate
efficacy
cancer
cell
elimination
through
synergistic
chemotherapy
approach
employed
ZC-DOX@GEL.
acceleration
ROS
scavenging
attributes
ZC@GEL
corroborated
using
rat
models
healing.
results
underscore
potential
multifaceted
presented
herein
promising
application
treatments.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
20(1), P. 101017 - 101017
Published: Jan. 10, 2025
Biological
nanotechnologies
based
on
functional
nanoplatforms
have
synergistically
catalyzed
the
emergence
of
cancer
therapies.
As
a
subtype
metal-organic
frameworks
(MOFs),
zeolitic
imidazolate
(ZIFs)
exploded
in
popularity
field
biomaterials
as
excellent
protective
materials
with
advantages
conformational
flexibility,
thermal
and
chemical
stability,
controllability.
With
these
superior
properties,
applications
ZIF-based
combination
various
therapies
for
treatment
grown
rapidly
recent
years,
showing
remarkable
achievements
great
potential.
This
review
elucidates
advancements
use
ZIFs
drug
delivery
agents
therapy.
The
structures,
synthesis
methods,
modifiers
used
oncotherapy
are
presented.
Recent
advances
application
nanoparticles
single
or
tumor
treatments
reviewed.
Furthermore,
future
prospects,
potential
limitations,
challenges
nanomaterials
discussed.
We
except
to
fully
explore
present
clear
outline
their
an
effective
help
them
achieve
early
clinical
application.
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
The
first-in-class
oncolytic
peptide
LTX-315
has
exhibited
positive
anticancer
responses
in
multiple
phase
I/II
clinical
trials.
Nevertheless,
the
linear
suffers
from
poor
proteolytic
stability
and
undesired
toxicity,
especially
hemolysis,
which
may
limit
its
widespread
applications.
Except
for
direct
structural
modifications,
drug
delivery
systems
(DDSs)
are
expected
to
protect
degradation
shield
hemolytic
properties.
Therefore,
zeolitic
imidazolate
framework
(ZIF-8)-based
nanoparticles
(NPs)
were
constructed
with
a
high
encapsulation
rate
of
59.9%,
utilizing
biomineralized
"one-pot
method"
an
aqueous
system.
release
LTX-315,
vitro
potency,
serum
stability,
durability,
antimigration
activity,
hemolysis
effect,
subcellular
localization,
membrane
disruption/permeation
effects
LTX-315@ZIF-8
NPs
investigated.
potent
cytotoxicity
against
cancer
cells.
experiment
time-inhibition
curve
assay
indicated
that
ZIF-8
could
effectively
improve
prolong
duration
action,
enhance
cytostatic
potency.
Especially,
not
only
attenuated
toxicity
but
also
achieved
pH-responsive
LTX-315.
mechanism
investigation
possessed
membranolytic
activity
reduced
mitochondrial
potential
trigger
cell
death.
Collectively,
this
paper
established
robust
strategy
reduce
properties
provided
reliable
reference
future
peptides.
ACS Biomaterials Science & Engineering,
Journal Year:
2023,
Volume and Issue:
9(6), P. 3402 - 3413
Published: May 4, 2023
Current
anticancer
research
shows
that
a
combination
of
multiple
treatment
methods
can
greatly
improve
the
killing
tumor
cells.
Using
latest
microfluidic
swirl
mixer
technology,
combined
with
chemotherapy
and
photothermal-ablation
therapy,
we
developed
multiresponsive
targeted
antitumor
nanoparticles
(NPs)
made
folate-functionalized
gelatin
NPs
under
200
nm
in
size
encapsulated
CuS
NPs,
Fe3O4
curcumin
(Cur).
By
exploring
gelatin's
structure,
adjusting
its
concentration
pH,
fine-tuning
fluid
dynamics
device,
best
preparation
conditions
were
obtained
for
an
average
particle
90
±
7
nm.
The
comparative
targeting
drug
delivery
system
(DDS)
was
demonstrated
on
lung
adenocarcinoma
A549
cells
(low
level
folate
receptors)
breast
MCF-7
(high
receptors).
Folic
acid
helps
achieve
accurate
to
synergistic
photothermal
ablation
curcumin's
activity
are
achieved
through
infrared
light
irradiation
(980
nm),
while
is
guided
external
magnetic
field
target
accelerate
uptake
drugs,
thus
efficiently
method
described
this
work
simple,
easy
repeat,
has
great
potential
be
scaled
up
industrial
production
subsequent
clinical
use.
