Hydrogel-based platforms for site-specific doxorubicin release in cancer therapy
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Sept. 30, 2024
Language: Английский
Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment
Zainab Lafi,
No information about this author
Sina M. Matalqah,
No information about this author
Ebaa Abu-Saleem
No information about this author
et al.
Medical Oncology,
Journal Year:
2024,
Volume and Issue:
42(1)
Published: Dec. 9, 2024
Language: Английский
Hybrid Systems of Gels and Nanoparticles for Cancer Therapy: Advances in Multifunctional Therapeutic Platforms
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 170 - 170
Published: Feb. 26, 2025
Cancer
is
a
global
health
concern.
Various
therapeutic
approaches,
including
chemotherapy,
photodynamic
therapy,
and
immunotherapy,
have
been
developed
for
cancer
treatment.
Silica
nanoparticles,
quantum
dots,
metal–organic
framework
(MOF)-based
nanomedicines
gained
interest
in
therapy
because
of
their
selective
accumulation
tumors
via
the
enhanced
permeability
retention
(EPR)
effect.
However,
bare
nanoparticles
face
challenges
poor
biocompatibility,
low
stability,
limited
drug-loading
capacity,
rapid
clearance
by
reticuloendothelial
system
(RES).
Gels
with
unique
three-dimensional
network
structures
formed
through
various
interactions
such
as
covalent
hydrogen
bonds
are
emerging
promising
materials
addressing
these
challenges.
Gel
hybridization
enhances
facilitates
controlled
drug
release,
confers
cancer-targeting
abilities
to
nanoparticles.
This
review
discusses
gel–nanoparticle
hybrid
systems
treatment
past
five
years
analyzes
roles
gels
systems.
Language: Английский
A Self-Powered Casein Hydrogel E-Dressing with Synergistic Photothermal Therapy, Electrical Stimulation, and Antibacterial Effects for Chronic Wound Management
Acta Biomaterialia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
Fabrication of composite hydrogels from Carrageenan-cl-carboxymethyl chitosan-PVA incorporated ZiF-8 for wound healing applications
Tooba Yasin,
No information about this author
Muhammad Shahzad Zafar,
No information about this author
Muhammad Umar Aslam Khan
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
The
skin
is
the
largest
organ
of
human
body,
protecting
it
from
external
environment
and
pathogens
minimizing
risk
injury.
Hydrogels
have
attracted
a
lot
interest
lately
because
their
biomimetic
structure
inherent
extracellular
matrix
characteristics.
hold
great
promise
for
application
in
wound
healing,
mainly
they
can
very
conveniently
provide
bioactive
ingredients.
In
this
work,
composite
hydrogels
were
developed
healing
carrageenan,
polyvinyl
alcohol,
carboxymethyl
chitosan
by
blending
method.
These
characterized
advanced
techniques
such
as
FTIR,
XRD,
DSC,
SEM-EDX,
which
used
to
study
structural,
thermal,
surface
morphology,
elemental
behavior.
Their
physiochemical
analyses
performed
using
swelling
degradation,
water
contact
angle,
gel
fraction.
increasing
ZiF-8
causes
more
roughness,
with
decreased
different
media
(Aqueous>PBS>NaCl).
amount
less
hydrophilic
behavior
biodegradation
cytocompatibility
ZiF-8-based
potential
antibacterial
activities
against
Gram-positive
Gram-negative,
enhanced
ZiF-8.
caused
cell
viability
proliferation
proper
morphology
vivo
healing.
Hence,
results
show
that
synthesized
may
be
candidate
numerous
repair
applications.
Language: Английский
Recent development of ZiF-8 incorporated dressings for wound healing application: Current Insight and Future Perspective
Materials Today Communications,
Journal Year:
2025,
Volume and Issue:
unknown, P. 112652 - 112652
Published: April 1, 2025
Language: Английский
Advancements in chitosan-based nanocomposites with ZIF-8 nanoparticles: multifunctional platforms for wound healing applications
Carbohydrate Polymers,
Journal Year:
2025,
Volume and Issue:
unknown, P. 123656 - 123656
Published: April 1, 2025
Language: Английский
Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review
Journal of Polymers and the Environment,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 17, 2024
Language: Английский
Polydopamine Surface Engineering of Iron Single-Atom Nanozyme: a Novel Strategy for Doxorubicin Immobilization, Tumor Microenvironment Remodeling and Synergistic Multimodel Therapy
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 21, 2024
Abstract
The
variation
in
tumor
microenvironment,
specifically
the
levels
of
cellular
H
2O
2/O
2/GSH,
plays
a
crucial
role
effectiveness
cancer
therapy
nanozyme-drug
systems.
In
this
study,
bioinspired
polydopamine
was
utilized
to
surface
engineer
rhombic
dodecahedron
morphology
iron-based
SANzyme
(Fe
SANzyme),
which
exhibited
multiple
mimetic
activities
including
oxidase
(OXD)-like,
peroxidase
(POD)-like,
catalase
(CAT)-like,
and
glutathione
(GPx)-like
activities.
Fe
SAN-PDA
intricately
designed
as
nanoplatform
for
drug
immobilization,
remodeling
microenvironment
(TME)
enabling
synergistic
multimodal
therapy.
presence
abundant
quinone
structures
on
PDA
facilitated
creation
conductive
immobilization
doxorubicin
(DOX)
through
Michael
addition/Schiff
base
reaction.
SAN-PDA@DOX
can
catalyze
high
level
H
2O
2
TME
produce
oxygen
alleviate
hypoxia,
convert
produced
toxic
·OH,
deplete
intracellular
glutathione.
Coating
with
hyaluronic
acid
(HA)
enhanced
biocompatibility
targeting
ability
composite.
exceptional
photothermal
performance
SAN-PDA@DOX@HA,
combined
nanozyme
catalysis,
resulted
sustained
chemodynamic/photothermal/
chemotherapy
is
achieved
mouse
mammary
carcinoma
model.
This
research
highlights
therapeutic
effects
resulting
from
combination
multi-enzymatic
SAN
multifunctional
PDA,
offering
novel
strategy
Language: Английский
High precision acoustofluidic synthesis of stable, biocompatible water-in-water emulsions
Ultrasonics Sonochemistry,
Journal Year:
2024,
Volume and Issue:
111, P. 107120 - 107120
Published: Oct. 23, 2024
Language: Английский