Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 656, P. 320 - 331
Published: Nov. 20, 2023
Language: Английский
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 10, 2024
Over the past two decades, iron-based metal-organic frameworks (Fe-MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite great potential, transition of Fe-MOFs-based composites from laboratory clinical products remains challenging. This review evaluates key properties that distinguish Fe-MOFs other MOFs highlights recent advances synthesis routes, surface engineering, shaping technologies. In particular, it focuses on applications biosensing, antimicrobial, anticancer therapies. addition, emphasizes need develop scalable, environmentally friendly, cost-effective production methods for additional meet specific requirements various biomedical applications. ability combine therapies, hurdles still remain, including a deeper understanding therapeutic mechanisms potential risks resistance overdose. Systematically addressing these challenges could significantly enhance prospects potentially facilitate integration into mainstream practice.
Language: Английский
Citations
6
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151879 - 151879
Published: May 3, 2024
Language: Английский
Citations
5
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155438 - 155438
Published: Sept. 2, 2024
Language: Английский
Citations
5
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
5
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 673, P. 679 - 689
Published: June 17, 2024
Language: Английский
Citations
4
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 1, 2025
ABSTRACT Iron‐based nanomaterials (IBNMs) have been widely applied in biomedicine applications including magnetic resonance imaging, targeted drug delivery, tumor therapy, and so forth, due to their unique magnetism, excellent biocompatibility, diverse modalities. Further research on its enormous biomedical potential is still ongoing, new features are constantly being tapped demonstrated. Among them, various types of IBNMs demonstrated significant cancer therapy capabilities by regulating the microenvironment (TME). In this review, a variety iron oxide‐based (IONMs), iron‐based complex conjugates (ICCs), single atom (ISANMs) will be introduced, advantages TME would also emphasized. Besides, recent progress for diagnosis treatment through strategy modulating summarized, overcoming hypoxia, acidity, decreasing redox species, immunoregulation. Finally, challenges opportunities field briefly discussed. This review expected contribute future design development next‐generation TME‐modulate treatment.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Abstract In situ tumor vaccines, which utilize antigens generated during treatment to stimulate a cancer patient's immune system, has become potential field in immunotherapy. However, due the immunosuppressive microenvironment (ITME), generation of is always mild and not sufficient. Tumor‐resident intracellular bacteria have been identified as complete component contribute creating ITME. Herein, tumor‐resident scavenger designed induce enhanced antitumor photoimmunotherapy‐driven vaccines for treating hypoxic tumors. This developed by integrating photosensitizer CyI antibiotics Doxycycline (Doxy) into thermal‐sensitive tumor‐derived exosomes fused liposomes (ECDL). vitro vivo results showed that ECDL could homologous target cells restrict respiration mitochondrial reduce hypoxia, thus providing continuous oxygen eliminate both bacteria, ablating primary inhibiting metastasis recurrence. Moreover, eliminating neutralizes ITME triggers production bacterial‐related neoantigens, further strength study provided versatile effective are promising local, abscopal, metastatic treatment.
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 7, 2025
Iron-based nanomaterials (INMs), due to their particular magnetic property, excellent biocompatibility, and functionality, have been developed into powerful tools in both tumor diagnosis therapy. We give an overview here on how INMs such as iron oxide nanoparticles, element-doped nanocomposites, iron-based organic frameworks (MOFs) display versatility for imaging therapy improvement. In terms of imaging, improve the sensitivity accuracy techniques resonance (MRI) photoacoustic (PAI) support development multimodal platforms. Regarding treatment, play a key role advanced strategies immunotherapy, hyperthermia, synergistic combination therapy, which effectively overcome tumor-induced drug resistance reduce systemic toxicity. The integration with artificial intelligence (AI) radiomics further expands its capabilities precise identification, treatment optimization, amplifies monitoring. now link materials science computing clinical innovations enable next-generation cancer diagnostics therapeutics.
Language: Английский
Citations
0
Solid State Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 107867 - 107867
Published: Feb. 1, 2025
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 238, P. 113890 - 113890
Published: March 31, 2024
Language: Английский
Citations
2