Nanotechnology,
Journal Year:
2024,
Volume and Issue:
36(4), P. 045101 - 045101
Published: Oct. 30, 2024
Abstract
The
tumor
microenvironment
(TME)
is
characterized
by
low
pH,
hypoxia,
and
overexpression
of
glutathione
(GSH).
Owing
to
the
complexity
pathogenesis
heterogeneity
TME,
achieving
satisfactory
efficacy
with
a
single
treatment
method
difficult,
which
significantly
impedes
treatment.
In
this
study,
composite
nanoparticles
calcium-copper/alginate-hyaluronic
acid
(HA)
(CaO
2
-CuO
@SA/HA
NC)
pH
GSH
responsiveness
were
prepared
for
first
time
through
one-step
synthesis
using
HA
as
targeting
ligand.
Nanoparticles
loaded
H
O
can
enhance
chemodynamic
therapy
effects.
Simultaneously,
Cu
2+
generate
oxygen
in
TME
alleviate
hypoxia
tissue.
undergo
Fenton
reaction
produce
cytotoxic
hydroxyl
radicals
Ca
ions,
localization
clearance
cells.
Additionally,
sodium
alginate
(SA)
utilized
improve
biocompatibility
nanoparticles.
Fourier
transform
infrared,
x-ray
diffraction,
dynamic
light
scattering,
SEM,
transmission
electron
microscope,
other
analytical
methods
used
investigate
their
physical
chemical
properties.
results
indicate
that
CaO
NC
had
particle
size
220
nm,
narrow
distribution,
uniform
morphology.
hydrogen
peroxide
self-supplied
nanodrug
delivery
system
exhibited
excellent
pH-responsive
release
performance
glutathione-responsive
•OH
ability
while
also
reducing
level
reactive
oxide
species
quenching.
vitro
cell
experiments,
no
obvious
side
effects
on
normal
tissues
observed;
however,
inhibition
rate
malignant
tumors
HepG2
DU145
exceeded
50%.
preparation
nanoparticles,
achieve
both
chemokinetic
ion
interference
therapy,
has
demonstrated
significant
potential
clinical
applications
cancer
therapy.
Inorganic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(5), P. 1339 - 1365
Published: Jan. 1, 2024
The
review
covers
POMOF
materials
synthesis,
modification,
and
unique
properties,
focusing
on
biomedical
sensors
therapies.
Finally,
the
summarises
challenges
developments
of
POMOFs
in
biomedicine.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(9), P. 10532 - 10542
Published: April 18, 2024
Nanoscaled
metal–organic
frameworks
(MOFs)
have
great
prospects
in
drug
delivery.
As
a
unique
architecture,
MOF-on-MOF
has
emerged
as
promising
strategy
to
enhance
loading
and
release
efficacy.
Herein,
ZIF-8-on-ZIF-8
nanoplatform
been
fabricated
via
the
for
doxorubicin
(DOX)
loading,
resulting
core–shell
hierarchical
nanostructure
(DOX@ZIF-8-on-ZIF-8,
DZZ).
This
exhibited
pH
GSH
dual-responsive
DOX-releasing
behavior,
which
are
features
of
tumor
microenvironment
(TME).
Compared
monolayer
DOX-encapsulated
ZIF-8
(DOX@ZIF-8,
DZ),
DZZ
can
significantly
increase
efficiency
(DLE)
by
56-fold,
encapsulation
(DEE)
25-fold,
penetration
depth
DOX,
improve
selective
inhibition
on
breast
cancer
4T1
cells
both
vitro
vivo.
Such
ZIF-on-ZIF
provides
an
efficient
tumor-targeted
delivery
treatments.
Inorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
64(6), P. 2809 - 2814
Published: Jan. 31, 2025
UiO-66(Ce)
was
prepared
from
cerium
metal,
which
could
trigger
Fenton-like
reactions.
A
system
DOX@UiO-66(Ce)@TA-Fe
constructed
by
coating
a
metal
polyphenol
layer
(TA-Fe)
on
the
surface
of
DOX@UiO-66(Ce),
loaded
with
anticancer
drug
doxorubicin
hydrochloride
(DOX).
It
produce
reactive
oxygen
species
to
realize
chemodynamic
therapy
and
show
stimuli-responsive
release
behaviors
chemotherapy.
In
addition,
displayed
biocompatibility
normal
cells
(L929
cells)
toxicity
cancer
(MCF-7
cells),
implying
an
ideal
effect
for
multimodal
therapy.
