Biomedical applications of stimuli‐responsive nanomaterials DOI Creative Commons
Xiaojie Chen, Di Wu, Zhong Chen

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli‐responsive nanomaterials that can respond endogenous or exogenous stimulus display strong potentials biomedical applications. In comparison with conventional nanomaterials, improve therapeutic efficiency reduce the toxicity of drugs toward normal tissues through specific targeting on‐demand release at pathological sites. this review, we summarize responsive mechanism a variety stimulus, including pH, redox, enzymes within microenvironment, as well such thermal effect, magnetic field, light, ultrasound. After that, applications (e.g., delivery, imaging, theranostics) diverse array common diseases, cardiovascular cancer, neurological disorders, inflammation, bacterial infection, are presented discussed. Finally, remaining challenges outlooks future research directions for also We hope review provide valuable guidance developing accelerate diseases diagnosis treatment.

Language: Английский

Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System DOI Creative Commons
Weiran Ma, Xiaoying Wang, Dongqi Zhang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7547 - 7566

Published: July 1, 2024

Abstract: Cancer poses a significant threat to human life and health. Chemotherapy is currently one of the effective cancer treatments, but many chemotherapy drugs have cell toxicity, low solubility, poor stability, narrow therapeutic window, unfavorable pharmacokinetic properties. To solve above problems, target drug delivery tumor cells, reduce side effects drugs, an anti-tumor system based on microenvironment has become focus research in recent years. The construction reduction-sensitive nanomedicine disulfide bonds attracted much attention. Disulfide good reductive responsiveness can effectively high glutathione (GSH) levels environment, enabling precise delivery. further enhance targeting accelerate release, are often combined with pH-responsive nanocarriers highly expressed ligands cells construct systems. connect molecules polymer system, as well between different carrier molecules. This article summarized systems (DDS) that researchers constructed years bond microenvironment, cleavage-triggering conditions, various loading strategies, design. In this review, we also discuss controlled release mechanisms these DDS clinical applicability challenges faced translation. Keywords: bond, systems, GSH/ROS

Language: Английский

Citations

18
Applications and Enhancement Strategies of ROS-based Non-invasive Therapies in Cancer Treatment DOI Creative Commons
Qiuyan Guo,

Yingnan Tang,

Shengmei Wang

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515

Published: Jan. 1, 2025

Language: Английский

Citations

2
pH-responsive oxygen self-sufficient smart nanoplatform for enhanced tumor chemotherapy and photodynamic therapy DOI
Xinhe Liu, Xin Wang,

Dan Zang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 675, P. 1080 - 1090

Published: July 14, 2024

Language: Английский

Citations

6
Recent Advances in Hollow Nanostructures: Synthesis Methods, Structural Characteristics, and Applications in Food and Biomedicine DOI
Yajuan Li, Jingbo Liu,

David Julian McClements

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(37), P. 20241 - 20260

Published: Sept. 10, 2024

The development and investigation of innovative nanomaterials stand poised to advance technological progress meet the contemporary demand for efficient, environmentally friendly, intelligent products. Hollow nanostructures (HNS), characterized by their hollow architecture, exhibit diverse properties such as expansive specific surface area, low density, high drug-carrying capacity, customizable structures. These elaborated structures, encompass nanospheres, nanoboxes, rings, cubes, nanowires, have wide-ranging applications in biomedicine, materials chemistry, food industry, environmental science. Herein, HNS cutting-edge synthesis methods, including solvothermal liquid-interface assembly self-templating methods are discussed in-depth. Meanwhile, potential biomedicine packing, biosensor, drug delivery over past three years summarized, together with a prospective view future research directions challenges. This review will offer new insights into designing next generation applications.

Language: Английский

Citations

4
Near-Infrared Light-Controlled Nitric Oxide Delivery Combined with In Situ Activated Chemotherapy for Enhanced Multimodal Therapy DOI

Bing Ren,

Jing Liu, Yi Wang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Development of nanoplatforms with in situ activation for chemotherapy represents a promising modality biomedical application. Herein, multifunctional nanoplatform, CMS@DTC@PDA@RuNO@FA (abbreviated as CDPNF NPs), was developed highly efficient antitumor therapy, which diethyldithiocarbamate (DTC)-loaded mesoporous Cu2MoS4 (CMS) nanoparticles were covered by polydopamine (PDA) layers and further covalently modified NO donor (RuNO) folic acid (FA)-directing moiety. Under the mild acidic tumor microenvironment (TME), NPs co-liberated DTC Cu2+ site, where formation cytotoxic Cu(DTC)2 complex effectively killed cells. Furthermore, under near-infrared (NIR) light irradiation, could deliver nitric oxide (NO) produce superoxide anions (O2•-), followed more toxic peroxynitrite (ONOO-), led to promoted cell apoptosis. 1064 nm NIR vivo experiments demonstrated an impressively high inhibition rate (∼97%) while good biocompatibility. This work activated approach precision medicine that might imply its potential clinical applications.

Language: Английский

Citations

0
Polypyrrole@MnO2 fluorescence nanocomposites as a multifunctional architecture for glutathione sensing and synergistic therapy of cancer DOI
Bei Li, Xiaoran Zhang,

Xincheng Sun

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112852 - 112852

Published: Jan. 1, 2025

Language: Английский

Citations

0
Biomedical applications of stimuli‐responsive nanomaterials DOI Creative Commons
Xiaojie Chen, Di Wu, Zhong Chen

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli‐responsive nanomaterials that can respond endogenous or exogenous stimulus display strong potentials biomedical applications. In comparison with conventional nanomaterials, improve therapeutic efficiency reduce the toxicity of drugs toward normal tissues through specific targeting on‐demand release at pathological sites. this review, we summarize responsive mechanism a variety stimulus, including pH, redox, enzymes within microenvironment, as well such thermal effect, magnetic field, light, ultrasound. After that, applications (e.g., delivery, imaging, theranostics) diverse array common diseases, cardiovascular cancer, neurological disorders, inflammation, bacterial infection, are presented discussed. Finally, remaining challenges outlooks future research directions for also We hope review provide valuable guidance developing accelerate diseases diagnosis treatment.

Language: Английский

Citations

2